Sentences with phrase «on disease stage»

Not exact matches

Darzalex, however, has not yet reached its peak potential as the drug moves into earlier stages of the disease and is being tested on solid tumours like lung cancer.

• Clementia Pharmaceuticals, a Montreal, Canada - based clinical stage biopharmaceutical company focused on bone diseases, filed for an IPO to raise $ 115 million.

Still, more drugs are in late - stage trials that could have an impact on the disease, and researchers are pinning hopes on diagnosing the disease early, before symptoms even show up.

Solanezumab, a drug developed by Eli Lilly that also acts on the amyloid hypothesis, failed some key clinical trials, though the company is still testing it in the pre-clinical stages of the disease.

Fernando Pagan, a GUMC associate professor of neurology who directs the Movement Disorders Program at MedStar Georgetown University Hospital, said that to his knowledge, the study «represents the first time a therapy appears to reverse — to a greater or lesser degree depending on stage of disease — cognitive and motor decline in patients with these neurodegenerative disorders.»

CalciMedica is a privately - held, clinical stage biopharmaceutical company focused on CRAC channel drug discovery and development for the treatment of acute and chronic inflammatory diseases.

At the Challenge Festival, startups like as BaseTrace, which «uses DNA - based tracers to track where industrial fluids are going in large, complex environments» and Reliefwatch, a cloud - based system that uses smartphone technology to track inventory and diseases for healthcare organizations in the developing world, battled it out on stage for a grand prize of $ 150,000 in investment.

It would also set the stage for the next items on the list of diseases it hopes eventually to wipe out, starting with malaria.

Acorda said the cost reductions would help the company focus on its two late - stage studies for Parkinson's disease.

Novavax, Inc. (NASDAQ: NVAX), a small - cap clinical - stage vaccine company that focuses on therapies for both known and newly emerging diseases, has lost some support from a Wall Street analyst.

Role of Breastfeeding Cessation in Mediating the Relationship between Maternal HIV Disease Stage and Increased Child Mortality among HIV - Exposed Uninfected Children Author (s): Fox MP, Brooks DR, et al., Published: 2009 Summary: This study, published in the International Journal of Epidemiology, analyzed the role of breastfeeding cessation and its effect on mortality of HIV - exposed children.

By the time Artvoice published last week the comments Paladino made in a year end survey — saying he wished death by mad cow disease upon President Barack Obama and wanted First Lady Michelle Obama to be «let loose in the outback of Zimbabwe where she lives comfortably in a cave with Maxie, the gorilla» — the developer was already on a national stage poised for scrutiny from some of the country's largest media outlets, including The New York Times, Washington Post and CNN.

«But we have to be honest and say that, based on all the evidence, including data presented by the drug companies themselves, our experts have concluded that these drugs do not make enough of a difference for us to recommend their use for treating all stages of Alzheimer's disease.

The councilman also invited up on stage Omar Audi, a 9 - year - old Astoria resident originally from Lebanon who has hereditary angiodema, a rare and potentially fatal swelling disease.

Studies on the origins of BSE — a fatal disease marked in the early stages by loss of balance — gained urgency with the 1996 emergence in humans of the BSE - like new variant Creutzfeldt - Jakob disease (nvCJD).

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

«Unfortunately, most clinical trials to date have focused on patients whose cognitive deficits are already mild to severe, and when the therapeutic opportunities in this late stage of the disease are minimal.

AveXis, Inc., a clinical - stage gene therapy company developing treatments for patients suffering from rare and life - threatening neurological genetic diseases, announced in July 2016 that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation for the treatment based on preliminary clinical results from the trial of AVXS - 101.

«Despite the progress and the success of viral eradication, numerous questions remain unanswered such as response based on race, still difficult - to - treat situations such as patients with end - stage liver disease or undergoing hemodialysis, access to and affordability of these therapies, improvement in quality of life, and cost - effectiveness.

«Based on the results of this study, the side of origin of CC [colon cancer](left vs. right) should be acknowledged as a criterion for establishing prognosis in both earlier and advanced stages of disease.

The first, called bio-bar-code assays, relies on nanoparticles designed to attach themselves to specific disease - causing proteins; these will vastly improve a doctor's ability to detect diseases like cancer and Alzheimer's in their early stages and to identify pathogens like anthrax.

The researchers, from Children's Hospital of Philadelphia and Penn Medicine, focused on protein - losing enteropathy (PLE), a severe loss of proteins in the intestine that is a rare but potentially life - threatening side effect of staged heart surgery in patients with single - ventricle disease.

Alzheimer's is an agonizingly slow process, so by the time we get to study the disease itself during its late stages, all kinds of things have gone on that may be just consequences of disease rather than causal.

It is difficult at this stage to foresee the full impact of post-zygotic mutations in terms of treatment options for disease because the study was mainly focused on the technological aspects of these genetic changes, the researchers say.

«Non motor features are common in PD patients, occur across all disease stages, and while well described, are still under - recognized when considering their huge impact on patients» quality of life,» says Lisa Klingelhoefer, MD, a fellow at the National Parkinson Foundation International Centre of Excellence, Department of Neurology, King's College Hospital and King's College, London.

Data extracted included whether sofosbuvir was covered and coverage criteria based on liver disease stage; HIV coinfection; prescriber type; and drug / alcohol use.

In 2015, 87,538 patients with end - stage renal disease died while on dialysis (16.3 percent of all dialysis patients are awaiting kidney transplants), and 18,805 kidney transplantations were performed that same year.

Bedrosian notes that it was important that the study focused solely on women with Stage I disease in order to keep the study group homogenous and because in this cohort few would be ineligible for BCT.

«Aβ accumulates in the brain at the very early stages of Alzheimer's disease,» explains Osaka University Associate Professor Masayasu Okochi, an expert on the disease who managed the project.

Professor Fallon said: «This identification of an early stage cellular checkpoint that can act as a break on allergic responses has important implications for the development of new therapeutic approaches for asthma and other allergic diseases.»

A study published on January 7th in PLOS Pathogens identifies a new drug target, and supports the conclusion that iron - dependent signals generated in the mitochondria are essential for the development of parasite stages that cause disease in humans.

To date, no licensed drugs have shown a convincing impact on this later stage of the disease.

Patients affected by Parkinson's disease often show marked changes in body weight: they may gain or lose a lot of weight depending on the stage of the disease, or they may put on up to ten kilos after deep brain stimulation (a treatment to alleviate the symptoms).

An initial clinical trial of simvastatin in people with early - stage MS showed reductions in brain lesions, suggesting an effect on the underlying disease process.

A team of researchers led by UNSW Australia scientists has discovered how connections between brain cells are destroyed in the early stages of Alzheimer's disease — work that opens up a new avenue for research on possible treatments for the degenerative brain condition.

But while this approach is good at diagnosing the disease at later stages, it can miss the disease early on when antibody levels are low.

«Past studies and patient data have shown that we can improve a person's quality of life and chance of surviving end - stage renal disease if we can avoid or minimize the amount of time they spend on dialysis,» says Ankit Sakhuja, M.B.B.S., a graduate of Mayo Clinic Renal Transplant Fellowship.

Horses with the condition often have a wide range of clinical signs depending on the stage of the disease, from loss of energy to muscle wasting, and the condition is more common in older horses.

By the Duke researchers» calculations, surgeons operating on patients with a stage T1b tumor (more than 1 cm, but less than 2 cm at its widest point) can be 90 percent sure they have contained the cancer if they remove 6 lymph nodes around the tumor that test negative for the disease.

The study, a retrospective survival analysis, included 229 patients who participated in two randomized, controlled clinical trials focused on relief of constipation for patients receiving palliative care for various types of late - stage cancer and other terminal diseases.

According to Halassa, the new research sets the stage for ever more detailed studies on the complex behavior involved in how the mammalian brain pays attention to what's important, and especially how those neural circuits are broken in cases of attention - deficit diseases, such as ADHD, autism, and schizophrenia.

They hope to expand their sample range and explore these regions further to better understand the route traveled by the disease, the evolutionary changes it acquired at different stages, and the toll it had on the human population.

One of the reasons for this is the lack of knowledge on the cellular mechanisms which cause alterations in nerve transmissions and the loss of memory in the initial stages of the disease.

Factors such as gender, smoking, asbestos exposure and disease stage did not have an effect on whether patient's disease was positive for PD - L1 expression, but researchers did find that expression of the protein was more common in non-epithelial tumours compared to epithelial tumours.

Most prior studies have focused on end - stage renal disease.

here is epidemiological evidence that links type B coxsackie virus (CVB) infection with heart disease, and research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.

«On the flip side of that, I would say that if you are able to demonstrate anti-cancer activity in a dog with very advanced disease, then it would be likely that you would have equivalent or better activity in people with a less advanced stage of the disease,» Fan said.

Along with the researchers» previous findings on silent engrams in early Alzheimer's disease, this study suggests that re-activating certain synapses could help restore some memory recall function in patients with early stage Alzheimer's disease, Roy says.

Christophe Benoist, M.D., professor of Microbiology and Immunobiology at Harvard Medical School, (who spoke on behalf of Diane Mathis, Ph.D., also a professor in the same department) discussed a molecule called I - BET that, when used as a treatment in animals during pre-diabetes or in the early stages of clinical type 1 diabetes, seemed to slow the progression of the disease.

Table 2: Taxa present in the cervix of the patient with stage III endometriosis on the day of surgery that demonstrate a significant community level shift associated with disease.