Sentences with phrase «on htt»

We also had no effect on Htt aggregation levels through chronic dosing.

Not exact matches

Lloyd and BamBrogan also took issue with recent media reports saying that HTT was «breaking ground» on a test track in the planned Quay Valley development in California.

Musk, whose interests span electric cars, solar power and space rockets, isn't interested in commercially developing the idea, so a number of companies, including HTT, have pounced on it.

HTT says it was the first to take on Musk's project in 2013, and claims that the other two firms named their businesses after HTT and used its logo.

For example, we can sell excess energy to the grid as well as implement premium services, such as premium advertising,» Bibop Gresta, HTT chairman and chief operating officer, told CNBC Asia on Friday.

According to an announcement from Hyperloop Transportation Technologies (HTT) on Thursday, the project has added to its roster of engineers and architects.

Since then, a research company called Hyperloop Transportation Technologies (HTT)-- unaffiliated with Musk or any of his other companies and ventures — is right on track to making science - fiction legit science by building an actual test track for the technology in California.

HTT plans to break ground on the project in May 2016 in Quay Valley, California.

Hyperloop Transportation Technologies (HTT) announced plans for a 5 - mile test track late last year and is about to break ground on an initial framework for what HTT CEO Dirk Ahlborn hopes will become the U.S. transportation infrastructure of the future.

HTT bought land last year to begin initial construction on the Hyperloop in Quay Valley — a proposed 75,000 resident, solar - powered concept city being built in King's County, California that intends to use HTT's test track as its main transportation system.

Treatments for Huntington's have typically focused on blocking the activity of the mutant HTT protein, the assumption being that the altered form of the protein was more active than normal, and therefore toxic to neurons.

Next we these tools to explore how mutations in the HTT protein impact on human cortical development and human neuronal and astroglial functions.

We also investigated the effect of the adult - onset HD mutation on the role of HTT during spindle orientation in NSCs derived from HD - hESCs.

By combining SNP - targeting allele - specific silencing and gain - of - function approaches, we showed that a 46 - glutamine expansion in human HTT was sufficient for a dominant - negative effect on spindle orientation and changes in the distribution within the spindle pole and the cell cortex of dynein, p150Glued and NuMA in neural cells.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

Reduction of endogenous striatal htt using siRNA in rats expressing Htt171 - 82Q had no further detrimental effect on neuronal survival nor htt inclusion load indicating that partial inactivation of endogenous WT htt in the adult striatum (~ 50 %) had no major impact on the course of HD pathology (Drouet et al, 2009).

Unfortunately, that means that about one third of people have the same ribbons at these points on both the good and bad kites, so these drugs wouldn't specifically target the mutant HTT gene.

They zeroed in on the serotonin transporter gene (HTT), which codes for a protein that re-absorbs serotonin into the nerve cell after it has been released.

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On Thursday, I shared my bemusement upon rediscovering Hot Tuna (HTT: LN).

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JumpStartFund's Hyperloop Transportation Technologies (HTT) announced on Friday it has formed a partnership with Deutsche Bahn to create an «Innovation Train,» which is described as a conventional train that will use new technologies being developed by HTT that increases efficiency and to bring a modern digital presence to today's train transportation.

Adults who had been categorized as behaviorally inhibited at the age of 2 years exhibited a higher amygdala activation in response to unknown vs familiar faces16 compared with adults who were uninhibited as children, consistent with the notion that novel or ambiguous environmental stimuli of potential biological relevance activate the amygdala.17 Turning to genes that can influence the neurobiological bases of the processing of emotions, 2 common alleles, the short (S) and the long (L), in a variable repeat sequence of the serotonin transporter (5 - HTT) promoter polymorphism (5 - HTTLPR) on human chromosome 17q11 have been differently associated with greater amygdala activity in response to angry or fearful faces18 in healthy adults.

Higher 5 - HTT CpG methylation, but not sequence variation in the serotonin transporter promoter region, exacerbates the effects of early life stress on behavioral stress reactivity.

Early adversity and 5 - HTT / BDNF genes: New evidence of gene — environment interactions on depressive symptoms in a general population