Not exact matches
To find out what was going
on in the
microbiomes of four sets of differently shaped identical twins, researchers transferred some
gut bacteria from a lean (
human) twin to a sterile mouse: one with no foreign bacteria at all.
There is growing interest in the role of the
gut microbiome and its effect
on human health.
Previous studies have shown that a high fat maternal diet during gestation and lactation has a long - term impact
on the infant's
gut microbiome (the community of bacteria living inside the
human gut.)
In a study to be presented Thursday, Jan. 26, in the oral plenary session at 1:15 p.m. PST, at the Society for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, researchers with Baylor College of Medicine, Houston, Texas and University of California, San Diego, La Jolla, California, will present their findings
on a study titled, Maternal Diet Structures the Breast Milk
Microbiome in Association with
Human Milk Oligosaccharides and
Gut - Associated Bacteria.
«Cultural revolution in the study of the
gut microbiome:
Human gut - on - a-chip technology used to co-culture gut microbiome, human intestinal cells could lead to new therapies for inflammatory bowel diseases.&r
Human gut -
on - a-chip technology used to co-culture
gut microbiome,
human intestinal cells could lead to new therapies for inflammatory bowel diseases.&r
human intestinal cells could lead to new therapies for inflammatory bowel diseases.»
The Wyss team believes the ability of the
human gut -
on - a-chip to culture the
microbiome with
human gut cells also holds promise for the field of precision medicine, where a patient's own cells and
gut microbiota could one day be cultured inside a
gut -
on - a-chip for testing different therapies and identifying an individualized treatment strategy.
With our
human gut -
on - a-chip, we can not only culture the normal
gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»
In this latest advance reported in PNAS, the Wyss team showed that the
human gut -
on - a-chip's unique ability to co-culture intestinal cells with living microbes from the normal
gut microbiome for an extended period of time, up to two weeks, could allow breakthrough insights into how the microbial communities that flourish inside our GI tracts contribute to
human health and disease.
«The distal
gut of a
human is one of the densest microbial ecosystems
on the planet,» says Stanford University microbiologist David Relman, a pioneer in
human microbiome research.
(
Gut bacteria are part of the
microbiome, the larger community of microbes that exist in and
on the
human body.)
Large - scale genome sequencing efforts, like the
Human Microbiome Project, have focused on the community of microorganisms that live in the human
Human Microbiome Project, have focused
on the community of microorganisms that live in the
humanhuman gut.
Since the
human body plays host to vast numbers of bacteria, particularly our
gut microbiome, this effectively means that there is a bacterial war going
on inside us.
«In the future, such efforts could allow us to much better understand
human -
microbiome interactions, model malnutrition disorders and inflammatory diseases of the
gut, and perform personalized drug testing,» said co-first author Alessio Tovaglieri, a Graduate Student at the Department of Health Science and Technology at ETH Zurich in Switzerland, who performs his thesis work
on Ingber's team.
Warinner and colleague, Cecil M. Lewis, Jr., co-direct OU's Laboratories of Molecular Anthropology and
Microbiome Research and the research focused on reconstructing the ancestral human oral and gut microbiome, addressing questions concerning how the relationship between humans and microbes has changed through time and how our microbiomes influence health and disease in diverse populations, both today and in
Microbiome Research and the research focused
on reconstructing the ancestral
human oral and
gut microbiome, addressing questions concerning how the relationship between humans and microbes has changed through time and how our microbiomes influence health and disease in diverse populations, both today and in
microbiome, addressing questions concerning how the relationship between
humans and microbes has changed through time and how our
microbiomes influence health and disease in diverse populations, both today and in the past.
«We found that when you perturb
gut microbes early in life among mice and then stop the antibiotics, the microbes normalize but the effects
on host metabolism are permanent,» says senior author Martin Blaser, MD, the Muriel G. and George W. Singer Professor of Translational Medicine, director of the NYU
Human Microbiome Program, and professor of microbiology at NYU School of Medicine.
While strides have been made in our effort to understand the importance of the complex
human microbiome, the exact functions of the majority of our
gut associates remain unknown, as is their impact
on our metabolism and overall physiology.
April 19, 2018 -
On Wednesday scientists announced in the journal «
Microbiome» that dogs and
humans share very similar
gut microbiomes that are closely related strains of the same species.
Nelson and her team led the first
human microbiome study
on the
human gut which was published in the journal Science in 2006.
Of note today: An evaluation of multi-site
human microbiome temporal stability over six months; The impacts of 1,000 non-antibiotic drugs
on the in vitro
gut microbiome; Caspase - 1 might modulate the relationship between stress, the
gut microbiome, inflammation and depressive - like behaviour in mice; And the impact of warming
on the Antarctic soil
microbiome
A few interesting articles in early life
human microbiome, plus: A comparison between Staphylococcus epidermidis commensal and pathogenic lineages from the skin of healthy individuals living in North American and India; A new tool to reconstruct microbial genome - scale metabolic models (GSMMs) from their genome sequence; The seasonal changes in Amazon rainforest soil
microbiome are associated with changes in the canopy; A specific class of chemicals secreted by birds modulates their feather
microbiome; chronic stress alters
gut microbiota and triggers a specific immune response in a mouse model of colitis; and evidence that the short chain fatty acids profile in the
gut reflects the impact of dietary fibre
on the
microbiome using the PolyFermS continuous intestinal fermentation model.
The new paper, titled «Using Machine Learning to Identify Major Shifts in
Human Gut Microbiome Protein Family Abundance in Disease,» was presented last month at the IEEE International Conference
on Big Data.
To explore the
microbiome's response to non-antibiotic drugs, the researchers individually tested nearly 1,200 medications — 835 of which have
human - cell targets —
on 38 species of
gut bacteria in vitro.
Shows you how your bacterial strains and levels compare to the National Institutes of Health's
Human Microbiome Project data
on gut bacterial strains
The delicate balance between the
human microbiome and the development of psychopathologies is particularly interesting given the ease with which the
microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the
gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect
on behaviour.
Influence of diet
on the
gut microbiome and implications for
human health.
Research
on human and
gut microbiome is continuing to evolve, but what we do know is that the composition of microbes in our
gut may influence way more than just digestion.
Our skin has good bacteria that is «live» and already there, called
human microbiome and we experience constant challenges in our
gut and
on our skin with the good vs the bad bacteria.
Before looking at the best way to maintain a healthy
gut microbiome, let's briefly take a look at the other effects of alcohol
on the
human body.
The
microbiome — colonies of various microbes that reside in the
gut and elsewhere in and
on the body — is an essential component of wellness for both animals and
humans.
Dr. Knights said the research team confirmed
human - like
gut microbiomes in 10 different primate species in four different zoos
on three continents.