Sentences with phrase «on rna»

Thereafter, negotiated global settlement agreement by which UMass became a co-owner of Max Planck's competing patent applications on RNA interference.

To annotate the genome, the team generated transcriptome sequence data — which can be used to measure gene expression based on RNA levels — in 12 different tissues types.

If RNA - Extraction with our QIA Symphony robot is requested, input material depends on the RNA / miRNA extraction kit used.

Ubiquitin - dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon

She characterized a family of enzymes called ADAR (adenosine deaminase acting on RNA) that are responsible for RNA editing.

«On RNA Cell Faring Programs» \ nhttps: / / www.the-scientist.com/community/posts/list/260/122.page#5133\n\nC.

Gordon Conference on RNA editing: Diversifying the Transcriptome: Consequences for Development and Disease, March, 2015 http://www.grc.org/programs.aspx?id=12665

Full length transcripts of Lcn16 and Lcn17 were obtained using 5 ′ and 3 ′ RACE kits (Invitrogen) on RNA from VNO and OM tissue following the manufacturer's instructions.

This open - ended approach relies heavily on RNA sequencing, a cutting - edge technique to identify genes whose expression is enhanced or diminished by a particular condition.

Uncertain - If the antibody - staining pattern contradicts experimental data or no expression is detected on the RNA level.

(A) RT - qPCR was performed on RNA extracted from larval tissues.

qRT - PCR on the RNA collected from 3 — 6 days - old whole flies performed with the primers specific for Defensin (A), Diptericin (B) Cecropin A1 (C) and Drosomycin (D).

The research focuses on the RNA polymerase pathway, POL I, which is necessary for mutant cancer genes to communicate with cells.

Functional analysis of genes with recurrent exons (i.e., with association with PMI in more than two tissues) shows a noteworthy enrichment on RNA binding and RNA splicing genes (Supplementary Fig. 18b, c).

CRISPR - Cas9, a system used to edit DNA sequences, can be used on RNA in living cells.

The second is that one of the options available in the programme was a project on RNA - binding proteins as markers of cancer progression.

Birdsill, A. C., Walker, D. G., Lue, L., Sue, L. I. & Beach, T. G. Postmortem interval effect on RNA and gene expression in human brain tissue.

Gonzalez - Herrera, L., Valenzuela, A., Marchal, J. A., Lorente, J. A. & Villanueva, E. Studies on RNA integrity and gene expression in human myocardial tissue, pericardial fluid and blood, and its postmortem stability.

Join them for sessions on RNA Form and Function, RNA in Human Disease, and RNA - mediated Epigenetics as a part of the MAC - presented Issues in Depth symposia series, Gilded Strands: RNA Form, Function, and Role in Human Diseases.

Six speakers were ultimately selected to represent the next generation of cancer researchers, including GMI's very own Angela Ting for her work on RNA - mediated epigenetic silencing in human cancers.

She began working on RNA during her postdoctoral training with Phillip Sharp, Ph.D., Institute Professor, Koch Institute for Integrative Cancer Research at MIT, where she also received her Ph.D. in Biological Chemistry.

Several of the major proteins binding to m6A were identified, and methylation was shown to be dynamically deposited on RNA, in a pattern that it is highly conserved during evolution.

His Ph.D. work was on RNA virus genetics in the laboratory of Gail Wertz.

In the recent issue of Nature Communications, the authors describe how the guide molecule which, until now has been based on an RNA backbone, can in fact be made from a hybrid molecule incorporating DNA nucleotides.

Director of the Swiss national research center (NCCR) on RNA and disease

To demonstrate how well this method works, Mayer and colleagues tested it out on RNA polymerase, a well - studied machine in cells.

Because of the usefulness of this information, we set ourselves the goals of constructing a zebrafish gene set based on RNA - Seq alone and then identifying the highest quality models.

Around that time, the RNA field had reached a pinnacle, so Doudna pivoted to focus on RNA - protein interactions and the function of RNA molecules in cell biology.

«You have to decide either to give up on RNA, or say it formed somewhere other than Earth,» he says.

The technique, developed by two separate research groups, one at Princeton led by Thomas Gregor, associate professor of physics and the Lewis - Sigler Institute for Integrative Genomics, and the other led by Nathalie Dostatni at the Curie Institute in Paris, involves placing fluorescent tags on RNA molecules to make them visible under the microscope.

The other new Common Fund initiative launching in 2013 will focus on RNA molecules that cells secrete to communicate with each other.

In the splicing process, removal of an internal RNA segment causes the mature RNA product to refold such that it no longer will activate PKR, now allowing for unimpeded synthesis on this RNA of the essential globin protein chains at maximal rates, allowing for effective oxygen breathing.

A chemical tag on the RNA of the hepatitis C virus called N6 - methyladenosine (m6A) has been found to slow the production of new viruses.

The result was just what they had hoped for: The cell turned on its RNA - interference machinery and immediately destroyed the pathogen's RNA, which pretty much put a halt to the infection.

With continuous reporting and appraisals, some committee would note that he published little of import between insulin in 1952 and his first paper on RNA sequencing in 1967 with another long gap until DNA sequencing in 1977.»

«In some ways, it's safer to work on RNA,» he says.

No one knows why cephalopods are so keen on RNA editing.

«People ask me which diseases these RNAs are going to be involved in,» says Thomas Cech, a biochemist at the University of Colorado at Boulder and a Nobel laureate for his work on RNA's role as an enzyme.

Heavy reliance on RNA editing, however it first evolved, practically would have guaranteed the need for cephalopod DNA to remain fairly stable over millennia.

In other words, in an animal reliant on RNA - editing for survival, any mutations that interfered with that process would probably not have survived into the next generation.

That means the oddball entity could be a molecular relic from the RNA world, which predated the evolution of DNA, lending credence to the idea that life depended first on RNA.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

So four years ago, Szostak decided to expand his research on the RNA world: He set out to find a simple way to enclose his ribozymes.

The issue also featured a two - page design spread introducing readers to a special section on RNA.

ScienceRNA.png Trade magazine Graphic Design USA selected the 17 June cover of Science, as well as a design accompanying the issue's special section on RNA, as one of the year's best examples of publication design.

The company is developing immunotherapies for cancer and prophylactic vaccines against infectious diseases, both based on RNA molecules.

Shinde and Klein are not yet sure whether GSK - 3's effect on RNA splicing explains its role in mood disorders.

C. elegans is a microscopic worm that like humans highly expresses a family of proteins in the nervous system called ADARs — adenosine deaminases that act on RNA — a family that includes ADR - 1.

But an overlooked regulatory system based on RNA may hold the keys to development and evolution

Faithful readers will recall that I've written about three developing trends for the new year and beyond: self - aggregation, de-hospitalization, and (yesterday) the bet on RNA - based therapies.