Sentences with phrase «on a gene important»

Early life stress, such as an extreme lack of parental affection, has lasting effects on a gene important to normal brain processes and is also tied to mental disorders.

Given his training in developmental biology, Raman focused the team to seek a novel drug target on genes important to the development of model organisms — fruit flies (Drosophila) and yeast (Saccharomyces cerevisiae)-- rather than on oncogenes that transform a normal cell into a cancer cell.

Not exact matches

Conservative Christians are the homosexual person's greatest ally in one important way, Joe Carter argues in Gay Gene Eugenics, today's «On the Square» offering.

And on the world - food security front, ARS» Stuttgart center is closing in on genes that regulate rice's uptake and storage of iron, thiamine and other important vitamins and minerals — a pursuit that could bolster the nutritional value of this cereal grain crop as a staple food for roughly half the world's population.

The gene for NPAS4 was a top hit, and significant for an important reason: it is an early - onset gene, meaning that its effects could be exerted on the brain rapidly unless HDAC5 was there to inhibit it — just the molecular event Cowan and his team were seeking.

A major study conducted on twins shows that environmental factors may be at least as important as genes in causing autism.

But when they tried to pinpoint the genes involved, something unexpected happened: they stumbled on C1q, a gene for a protein important in the body's immune system.

University of Adelaide School of Molecular and Biomedical Science PhD student, Deborah Toledo - Flores, says: «the most important aspect of this work for us was to identify more genes on platypus Y chromosomes to reveal new leads about potential sex determining genes in these animals.»

The focus thereby was on microRNA — a short, single - stranded RNA molecule that is now recognised as playing an important role in gene regulation.

While most of biology and medicine focus on the key roles genes and chemicals play in the formation and control of living systems, the spatial arrangement of the components that make up those systems and the physical forces they experience are being increasingly recognized as equally important.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

The overexpression of an important gene that regulates energy metabolism can cause a severe shortening of lifespan in male fruit flies but has only a small negative effect on lifespans of female fruit flies, according to new research from North Carolina State University.

The research centres on miRNAs, small molecules that have an important role in turning genes on and off in different parts of the body.

«This gene has been on the agenda for human sex development, but it's quite important that a case has now been reported.»

In a new take on an old polemic, Ridley acts as mediator between biological and cultural determinists, arguing that genes and the environment play equally important roles in shaping human destiny.

In addition, they also found a second — and possibly more important — role that they hadn't expected, Maniatis says: IKKε was actively involved in turning on other antiviral genes within a cell.

Experiments with these mice suggest TREM2 is important for steering microglia toward amyloid and turning on genes that rev up their cleanup capabilities.

«It doesn't show how the presence or absence of the menopause affects Darwinian fitness,» how successful an individual is in passing on his or her genes to future generations, «which is the all - important evolutionary yardstick.»

In all CS cases, said Morrow who treats autism patients at the E. P. Bradley Hospital in East Providence, boys have a mutation on the SLC9A6 gene on the X chromosome that disables production of a protein called NHE6 that is important for neurological development.

«As a result of the previous study, we reported that SUMO is probably important for controlling expression of active genes because we found it on every gene we looked at, but only when they were turned on,» notes Rosonina.

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

The findings show an important role for epigenetics in bumblebees, and suggest that whether a gene is turned off or on depends on whether it comes from the father or the mother.

«Many research groups are looking at how genes are regulated from the perspective of which genes need to be turned «on» for a cell to advance to the next stage of development, but now we see that it's just as important to know which genes need to be turned «off,»» Cook - Andersen said.

«Depending on the research questions, it may also be important to define the appropriate strategy to use, either whole - genome sequencing or just targeting some genomic regions with a gene baiting approach,» says Besnard.

Another illustrative finding was that the sirt1 nuclear gene, which is an important but controversial gene in aging research, Rand said, shows different effects on longevity given different mitochondrial genomes.

Understanding this process - which is particularly important when cells are first taking on specialized identities such as nerve cells, muscle, skin, and so on - helps explain how complex organisms can arise from a finite number of genes.

When they had a closer look into the embryos, the team found that several important developmental genes that are normally switched off during early embryogenesis were turned on in embryos without H3K27me3.

In the September issue of G3, Cuomo et al. unveil the first whole - genome sequence of a clinical sample of C. krusei, providing leads on genes that may be important for the species» fluconazole resistance.

Dr Kat Arney, science communication manager at Cancer Research UK, said: «Only a tiny fraction of our DNA contains actual genes, and we know that at least some of the bits in between — often dismissed as «junk» — play important roles in controlling how genes get switched on and off at the right time and in the right place.

One case where the ordering of genes on a chromosome is important to their function is that of the Hox genes, which define the body patterns of most types of animals during development.

SRY has been well - investigated in previous research and is known to turn on a range of regulatory genes such as Sox9 and AMH that play an important role in male differentiation.

Our study shows that modifications on top of the DNA that control how genes are read may be even more important.»

«At this stage, it is unclear how many people with ALS have the UBQLN4 gene variant, and this will be important to determine,» says Ma, the senior author on the study who is Ann Marie and Francis Klocke, MD Research Scholar at the Manne Research Institute and Assistant Professor at Northwestern University Feinberg School of Medicine.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Professor Ronald Roepman, of the Radboud University Medical Center, Nijmegen, added: «We confirmed that each of the genes on the list were important for cilia using an independent method.

It's been an important question — many lung cancers depend on over-activation of the gene EGFR, but then when EGFR inhibitors like gefitinib or erlotinib are used, the cancers tend to activate other «kinases» that allow the cancer to by - pass around this dependence.

«Everyone was focusing on genes expressed in the brain,» says Levitt, «but this gene is important for repair of the intestine and immune function.

Niakan's group focused on a gene called OCT4 (also known as POU5F1), a master regulator of gene activity, which is important in mouse embryo development.

The human genome contains about 3 billion base pairs, but only about 2 percent of these base pairs represent protein - coding genes, meaning that whole - exome sequencing measures the genetic alterations focused on a small but very important fraction of the genome (as opposed to techniques of whole genome sequencing, which measures every nucleotide across the entire genome, regardless of whether these genes are expressed or silent).

These differences were found in parts of the DNA that turn genes on and off in specific brain regions, in this case a brain region important for spatial memory.

The study is «important as a proof - of - principle,» adds human geneticist Daniel MacArthur of the Broad Institute in Cambridge, Massachusetts, who himself is on the hunt for rare genes that protect against disease and wrote a commentary accompanying the new paper.

But scientists from the Julius - Maximilians - University of Wuerzburg in Germany have zeroed in on one mutation of a gene on chromosome 22 that appears to play an important role in catatonic schizophreniaa particularly severe form of the disease characterized by acute psychotic breaks and disturbed body movements.

«This research is an important addition to the field because previous studies looking at CYP gene variants and their effects on risks of repeat heart attacks, bleeding and death have included predominantly Caucasian patients of European ancestry,» Cresci noted.

Experiments in mice suggested an important role in long - term memory for CREB, one of many so - called transcription factors, proteins that switch genes on and off.

The process of figuring out which of these genetic differences lie on each chromosome is called haplotyping, and it's an important step toward identifying which version of a gene may cause disease.

«In a nutshell, what we found is that this gene has an effect on the frequency of these T follicular helper cells, which are important for the B cells and seem to be important for the disease,» says Dr. Kissler, who is also an assistant professor of medicine at Harvard Medical School.

Which parent a chromosome comes from is important because the activity of some genes varies depending on whether the genes are on a chromosome inherited from the mother or from the father.

Some scientists have criticized TCGA for focusing on gene sequencing while diverting funds from functional studies that can determine which of the hundreds of mutations are most important.

This gene codes for part of a protein complex, called the IL - 7 receptor, that is found on the surface of certain lymphocytes and is important for their maturation.

«Basically, most of our knowledge of what genes are important for environmental adaptation of trees has been educated guessing built on studies in the model plant, Arabidopsis, which is a member of the mustard family» said Amy Brunner, associate professor of molecular genetics in Virginia Tech's College of Natural Resources and Environment.