Sentences with phrase «on a gene located»

The researchers focused on a gene located on chromosome 15, which was previously shown to impact protein concentration.

Roving parts of the genomic machine can better access the open sections, and so have a better chance of turning on the genes located there.

Not exact matches

Some genes have a variety of different forms, which are located at the same position on a chromosome; an allele is such a variant form of a gene.

In 1999 Huda Zoghbi, a specialist in pediatric neurological disorders at Baylor College of Medicine in Dallas, found that RS was likely caused by a mutation in the gene Mecp2, located on the X chromosome.

Researchers think it acts on another gene called lymphocyte activation gene - III, located at the other end of the same chromosome.

The causative gene for Huntington's disease, HD, one of the first genes identified to cause an inherited disease, is located on chromosome 4.

Using this technique, the team first identified millions of short fragments of RNA located at the start of genes — at the so - called «5 [prime]» end, where genes are switched on.

By combining each mouse's genome, phenome, proteome and metabolome, the scientists were able to identify a particular gene, located on their chromosome 2, and whose presence plays an important role in the development of type 2 diabetes «The mice with a high - fat diet are more or less likely to develop diabetes depending on whether this gene is active or not,» said Evan Williams, LISP PhD student and the article's co-first author.

As the autism risk gene is located on the X chromosome and males have only one X chromosome (females have two), they are at greater risk.

Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains.

The new analysis, based on data assembled primarily by graduate student Yan - Jie Feng at Sun Yat - Sen University in Guangzhou, China, focused on the sequences of 95 genes located on chromosomes in the nucleus and how they changed over time.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Based on a defense mechanism in the immune system of bacteria that hunts and destroys invading viruses, CRISPR can locate and replace specific genes.

About 4 percent of people in the study carried one of these two rare variants, which are located in the vicinity of the MGST1 gene on chromosome 12.

In actual fact, the gene varies depending on the tissue where it is located (cerebral cortex, cerebellum, olfactory epithelium, etc.); in particular, what varies is the point in the «string» of code at which protein synthesis starts.

If the other gene were located on the part of the circle that was copied last, the ratio of KinA to Spo0F would be one - to - one only when DNA replication was nearly completed.

For any given gene, this sequence in fact changes depending on the tissue in which it is located.

For instance, the researchers found that an immune system gene called DUSP22A on chromosome 6 was duplicated, but its copy, DUSP22B, is located on chromosome 16.

On closer inspection, the scientists discovered that the three genes involved in producing miR135 are located in areas of the genome that are known to be associated with risk factors for bipolar mood disorders.

The international team, led by Professor Jacob George and Doctor Mohammed Eslam at the Westmead Institute, had previously identified that the common genetic variations associated with liver fibrosis were located on chromosome 19 between the IFNL3 and IFNL4 genes.

Most resistance genes, in wheat and other plants, code for protein receptors located inside cells; the Stb6 gene codes for a receptor protein on the cell's surface.

Based on the similarity in the DNA sequences located near the caspase - 12 gene, Tyler - Smith and his colleagues estimate that the nonsense mutation occurred about 500,000 years ago in Africa.

The issue of sex is particularly acute in preclinical studies of Rett syndrome, a disorder caused by mutations in a gene located on the X chromosome.

Defective genes can be caused by mutations in either the maternally - inherited mitochondrial genome (mtDNA) or more frequently, the genes located on the autosomes, the 23 pairs of chromosomes which are responsible for all traits and all other genetic diseases.

The researchers pinpointed three gene regions underlying tunnel length, located on chromosomes 1, 2, and 20, and one, located on chromosome 5, that determined whether escape tunnels were made.

«If we want to understand how genes are turned on and off, we need to know where the sequences that perform this function are located in the genome,» said Mitchell.

In contrast, cis - eQTLs — which account for the majority of genetic variation that affects gene expression — regulate genes located nearby on the same chromosome.

Next came the test to see if Martensen's tumor contained the ALK mutation, which occurs when a section of DNA in the ALK gene, located on chromosome 2, breaks apart.

CRE are Gram - negative bacteria that frequently express a gene that codes for carbapenemase — an enzyme that breaks down carbapenem and other antibiotics — and that is located on «mobile genetic elements» called plasmids, which can jump from one bacterium to another.

The gene is located on chromosome 1, an area that's been scrutinized for prostate cancer genes since 1996, when family studies revealed a link between a region of that chromosome and the disease (ScienceNOW, 21 November 1996).

Previous work had shown that the DNA region in question, a promoter located on chromosome 17, switches on a nearby gene coding for a protein that shuttles serotonin back into nerve cells so they can reuse it as a neurotransmitter.

It's linked to a mutation in the gene that makes the FMRP protein, located on the X chromosome.

The study has its roots 15 years ago, when Wang and colleagues cloned the Tex11 gene and found that it was specific to germ cells and was located on the X chromosome.

In parthenote - derived cell lines, they found a distinctive signature: Most genes were different on the two sets of chromosomes, but genes located close to the chromosome's center were largely identical.

Although the teams took very different approaches to solve the mystery of how those limbs vanished, both came up with similar results: Mutations in DNA located near a gene key to limb formation keep that gene from ever turning on, they report today.

By manipulating the same genes, Zuo and his colleagues induced supporting cells located in the inner ear of adult mice to take on the appearance of immature hair cells and to begin producing some of the signature proteins of hair cells.

In a second series of experiments, Fukaya showed that a single enhancer can activate simultaneously two genes that are located some distance apart on the genome and have separate promoters.

The evaluation using biostatistical methods revealed a clear connection with an altered gene: ISL1, which is located on chromosome five.

Some of these SNPs had previously been associated with different diseases and are located near «imprinted» genes — genes in which only the maternally or paternally inherited copy is «switched - on» to encode a protein.

Of 73 genes in this region identified by genetic analysis, 49 have been located on the sequence; P - element insertions have been mapped to 43 genes.

Miller said that the viral receptor gene, HYAL2, was located on a region of human chromosome 3 that is frequently altered in lung cancers.

A physicist turned computational scientist, Graber comes to the MDI Biological Laboratory from The Jackson Laboratory, also located in Bar Harbor, where he focused on computational approaches to understanding post-transcriptional gene regulation and interactions, while also working intensively to process, analyze and interpret the genome - scale data sets generated within the Patient Derived Xenograft (PDX) cancer study program.

Many HARs are located near genes that control fundamental developmental processes, 9 so their altered regulatory function could have profound effects on human biology.

The researchers looked for genes that make proteins located on the outside of the bacterial cell.

Males are at an increased risk of disease because they only have one copy of the X chromosome and therefore only one copy of the many genes located on the X chromosome.

In this breed, the researchers found a novel mechanism of regulating blood sugar levels via an interaction of genes located on two different chromosomes.

To fix genes on a microscopic scale, one cell at a time, the faulty code has to be located and physically cut — and that's what CRISPR - Cas9 does.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

It is located on the long arm of chromosome 15 in the LINGO1 gene, which encodes a protein that has been shown to affect how neurons are formed and signal each other.

The ospC gene is located on a plasmid, cp26, that is ubiquitously present in all examined isolates of B. burgdorferi (37, 38).