Sentences with phrase «on afferent»

Herein, we test whether 5 - HT released by taste cells plays a role in the transmission of taste information by activation of 5 - HT3 receptors on afferent nerve fibers.

The 5 - HT released by type III cells could also activate 5 - HT3 receptors on afferent nerve fibers.

Not exact matches

To quote the researchers: «Thus, modification of this PIP2 regulatory domain by genetic, biochemical, or pharmacological mechanisms may have profound effects on sensitivity of primary afferent nerve fibers to chemical and thermal stimuli under normal or pathological conditions.»

It was speculated that the exercising athlete did not take the incorrect distance information into account, but based their pacing strategy on previous experience, the initial knowledge of exercise duration and on physiological afferent inputs throughout the exercise bout (D in fig 2).

«If you relied on SA1 afferents alone for texture perception, you would not be able to discriminate most textures.

However, a paucity of information exists on the steps between taste receptor cell activation and afferent nerve fiber firing.

He previously served as Chairman and founding CEO of CoLucid Pharmaceuticals (NASDAQ: CLCD)(acquired by Eli Lilly in 2017), and on the boards of Afferent Pharmaceuticals (acquired by Merck in 2016), Chimerix (NASDAQ: CMRX), Quintiles Transnational Corp. (NASDAQ: QTRN now NYSE: Q), TYRX (acquired by Medtronic in 2013), Syntonix Pharmaceuticals (acquired by Biogen IDEC in 2007), LEAD Therapeutics (acquired by BioMarin in 2010), CardioDx, and Embrex (NASDAQ: EMBX)(acquired by Pfizer in 2006).

Afferents to the visual wulst were mapped by stereotactic iontophoretic application (4 µA positive current, 7 sec on / off, duration: 20 — 30 min) of biotinylated dextran amin (BDA, working dilution: 10 % in phosphate buffered saline, PBS; Molecular Probes Europe BV, Leiden, The Netherlands) into Cluster N or into medial parts of the visual Wulst.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

These «afferent signals», or signals that flow to the brain, have a regulatory influence on many aspects of your nervous system, including most of your glands and organs.

The H - reflex is produced by an electrical stimulus, which causes action potentials to travel up afferent nerves until they synapse on α - motor neurons.

(ref1, ref2, ref3) When podocytes loose their grip on the tiny incoming blood filtering vessels where they belong (the afferent glomerular arteriole capillaries), they wind up in the urine.