Sentences with phrase «on animal models of»

Workshop on Animal models of Disease, focused mainly on Rheumatoid Arthritis and other chronic inflammatory diseases.

The third webinar, and the final one will focus on animal models of obesity and diabetes, both talking about genetic models, as well as dietary models and how they are used in basic research, but also in pharmaceutical and biotech research.

For a decade, LJI's Toshiaki Kawakami, M.D., PhD., has defined mast cell signaling that either worsens or ameliorates eczema, relying heavily on animal models of atopic dermatitis that he established.

A new study, published in Nature Neuroscience, examined the effect of the anti-cancer drug romidepsin on animal models of autism.

«My former advisor at Oxford has a variety of interests, all very much based on animal models of how the brain is organized for skilled performance.

Research on Huntington's has thus far relied heavily on animal models of the disease, and has left many key questions unanswered.

Not exact matches

The Volvo S90 2017 model banners its «moose detector,» a trio of radar, camera and software aimed at identifying large animals on the road and avoiding situations such as car - deer collisions.

It is customary and even ethically mandatory that experimentation that carries with it a substantial degree of risk to human subjects first be tested in an animal laboratory or, at the very least, on a computer model.

We are to model our lives after Christ, the Son of God, who though he was God's very equal, came to earth, was born in an animal's feeding stall and died on a cross.

«What I've tried to do is create a sustainable organic farming model that is good for the earth, the soil, the animals, and the people working on these farms, and helps revitalize rural communities,» said Albert Straus, CEO and founder of Straus Family Creamery.

Modelled on the nucleotides that make up DNA, the movement of the Zoob's mirrors the natural mobility of people, animals and machines.

Based on animal models, including a primate model, it is hypothesized that the cells remain unharmed in the digestive tract of the infant then enter the bloodstream, migrate to different organs, and there provide active immunity.54

The Dr Hadwen Trust for Humane Research claims that «in some instances, reliance on inaccurate animal «models» of human disease have undoubtedly delayed medical progress.»

«Hi Tor operates as a no - kill shelter and we are here to help all animals survive and thrive, however we must be able to operate on a fiscally sound business model or risk insolvency and the possibility of putting these animals lives at risk.

Based on their findings, they urge that «mosquito saliva and enhancing antibodies thus need to be considered when developing vaccines and drugs against dengue,» and specifically suggest that «animal models of dengue and pre-clinical validation of dengue vaccine candidates should be evaluated in the combined presence of mosquito saliva and enhancing antibodies.»

New experimental models based on three - dimensional reconstructions of human skin are helping to reduce chemical testing on live animals, but can not yet replace animals altogether

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

«Our results using an animal model suggest that a maternal high - fat diet during pregnancy and lactation could have significant and lasting effects on the brain, behavior and cognition of rat pups,» said Dr. Tamashiro.

«Our findings confirm in humans what has been shown in animal models — that maternal obesity has a more significant impact on the body composition of boys than girls,» said Dr. Andres.

New research from McLean Hospital neuroscientists shows in an animal model that being bullied can have long - term, dramatic effects on sleep and other circadian rhythm - related functions, symptoms that are characteristic of clinical depression and other stress - induced mental illnesses.

Previously, animal models were all based on the early stage of metabolic dysfunction in the liver, which has allowed the development of good drugs for treating early - stage T2D.

It is shocking that Science would take the time and effort to highlight and chronicle the sentiments of someone whose sole mission is to derail biomedical research that is dependent on animal models.»

While scientists could do cellular work in animal models on the role of dopamine versus glutamate, and they could do EEGs in human beings, a bridge between the two remained elusive.

Nadeau also studies the potential impacts of climate change on species around the globe, using modeling, field observation and experiments to predict where species are most vulnerable and determine how conservation groups can best mitigate the negative impacts of climate change on animal populations.

Following up on these promising results, they decided to explore whether the drug SR8278 could slow the progression of muscular dystrophy in an animal model.

The study — which looked at the action of Substance P within nerve cells in the lab and in animal models — focused on acute pain, but Professor Gamper aims to look at its role within chronic pain as well.

«Despite the prevalence of abnormal sleep patterns in PD, very few studies to date have outlined sleep disturbances in animal models of PD,» says Sarah M. Rothman, PhD, a researcher with the National Institute on Aging, in Baltimore, MD..

Modeling how forces of locomotion act on an animal's bones — living or extinct — could help scientists understand why.

Using data from several sources on 162 terrestrial animals and plants unique (endemic) to the Albertine Rift, the researchers used ecological niche modeling (computer models) to determine the extent of habitat already lost due to agriculture, and to estimate the future loss of habitat as a result of climate change.

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

Its research includes a cluster of related interdisciplinary projects that examine disparities in breast cancer mortality between African - American and Caucasian women using animal models, molecular characterization of tumors, and behavioral research focused on social - environmental factors.

Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»

The study is one of the first to test if the «landscape of fear» model, a scientific theory that has been used to explain how animals move and interact with the environment based on their fear of being attacked by their predators, is applicable to large open marine systems involving wide - ranging species, like sharks and turtles.

«Most pain medications that have been tested in the past decade have failed in phase II human trials despite performing well in animal models,» notes Clifford Woolf, MD, PhD, director of Boston Children's F.M. Kirby Neurobiology Center and a co-senior investigator on the study with Michael Costigan, PhD.

Instead, most researchers have relied on animal models to learn more about the development and function of the pancreas.

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

Granular resistive force theory, which considers the thrust provided by the body waves and the drag on the animals» bodies, helped model the locomotion and compare the energy efficiency of the limbless snake against that of the four - legged lizard — which doesn't use its legs to swim through the sand.

«We have demonstrated for the first time in an animal model that maternal use of a class of antidepressants called selective serotonin reuptake inhibitors, or SSRIs, resulted in increased fat accumulation and inflammation in the liver of the adult offspring, raising new concerns about the long - term metabolic complications in children born to women who take SSRI antidepressants during pregnancy,» says PhD student Nicole De Long, who presented this research on June 22nd at the joint meeting of the International Society of Endocrinology and The Endocrine Society.

The researchers, who evaluated the BSCB in test animals at seven and 30 days after stroke modeling, found that ischemic stroke damaged the gray and white matter in the cervical spinal cord on both sides of the spinal column, based on analysis of electron microscope images.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

The researchers now plan to test this type of insulin in other animal models and are also working on tweaking the chemical composition of the insulin to make it even more responsive to blood - glucose levels.

The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell cultures, for example, or animal models — and uses them to develop new therapies or medical procedures.»

By using new techniques based on computerised X-ray micro-tomography (CT scan) and digital three - dimensional modelling, Benoit found that the maxillary canal of therapsids, a bony tube in the snout of the animal that houses the trigeminal nerve, is shorter in therapsids than in reptiles.

In the next five to 10 years, we'll eliminate much of animal toxicology and move on to smarter systems using computer algorithms and modeling,» he says.

To shed light on the mystery of Bornean elephant's origin, Chikhi and Goossens» team used genetic data analysis and computational modelling to study the past demographic history of these animals.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

Wild H5N1 viruses can not latch on tothe cells in a person's nose and throat, but the mutant strains created by Fouchier and Kawaoka can spread between ferrets, which are viewed as a good animal model of flu transmission between humans.

He built a computer model that could calculate the forces acting on the joints of a running bipedal creature in midstride and tell him how much muscle the animal would need in order not to collapse.

Signs of neuronal damage around plaques also varied depending on the APOE variant the animals received, and experiments in a different Alzheimer's model in which plaques appear more slowly showed that injection of APOE4 increased levels of free, soluble A-beta in the fluid that bathes the brain.