Sentences with phrase «on associated outcomes»

Not exact matches

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

Moderate interest rates were associated with a whole range of subsequent returns over the following decade, and we know that those outcomes were 90 % correlated with the level of valuations at the beginning of those periods (on reliable measures such as market cap / GDP, price / revenue, Tobin's Q, the margin - adjusted Shiller P / E, and others we've presented over time - see Ockham's Razor and the Market Cycle).

Such risks and uncertainties include, but are not limited to: our ability to achieve our financial, strategic and operational plans or initiatives; our ability to predict and manage medical costs and price effectively and develop and maintain good relationships with physicians, hospitals and other health care providers; the impact of modifications to our operations and processes; our ability to identify potential strategic acquisitions or transactions and realize the expected benefits of such transactions, including with respect to the Merger; the substantial level of government regulation over our business and the potential effects of new laws or regulations or changes in existing laws or regulations; the outcome of litigation, regulatory audits, investigations, actions and / or guaranty fund assessments; uncertainties surrounding participation in government - sponsored programs such as Medicare; the effectiveness and security of our information technology and other business systems; unfavorable industry, economic or political conditions, including foreign currency movements; acts of war, terrorism, natural disasters or pandemics; our ability to obtain shareholder or regulatory approvals required for the Merger or the requirement to accept conditions that could reduce the anticipated benefits of the Merger as a condition to obtaining regulatory approvals; a longer time than anticipated to consummate the proposed Merger; problems regarding the successful integration of the businesses of Express Scripts and Cigna; unexpected costs regarding the proposed Merger; diversion of management's attention from ongoing business operations and opportunities during the pendency of the Merger; potential litigation associated with the proposed Merger; the ability to retain key personnel; the availability of financing, including relating to the proposed Merger; effects on the businesses as a result of uncertainty surrounding the proposed Merger; as well as more specific risks and uncertainties discussed in our most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.cigna.com as well as on Express Scripts» most recent report on Form 10 - K and subsequent reports on Forms 10 - Q and 8 - K available on the Investor Relations section of www.express-scripts.com.

(Note: for more insights on the loss - return relationship, please read Venture Outcomes Are Even More Skewed Than You Think at Seth Levine's VC Adventure, and Venture Capital Disrupts Itself: Breaking the Concentration Curse by Cambridge Associates.)

The evidence that incentives based on group outcomes are associated with higher productivity contravenes the oft - repeated critique that employee stock ownership and profit sharing can not possibly work due to the incentive to «free ride.»

Based on historical outcomes associated with those prior instances (which prior to the current market cycle, include only 1929, 1972, 1987, 2000 and 2007), we continue to view the stock market as vulnerable to significant downside risk both in the near - term and over the completion of the present market cycle.

Most of the time, a given set of market conditions is associated with some mix of positive and negative outcomes, so we focus on the average of those outcomes in the expectation that doing so will produce good results over the complete market cycle even if we are incorrect in specific instances.

There is no area in social science in which the evidence stacks up so completely on one side: marriage and traditional family life are associated with good outcomes in terms of health, wealth, and other indicators of well - being.

Nutritionist Marion Nestle, whose voice we always listen for on these matters, warns that this study still does not prove that eating chocolate causes better health outcomes, only that it's been associated with them.

«This is a necessary step that can help save lives and reduce the risk of acute, chronic or fatal outcomes on the playing field,» says Ron Courson, ATC, PT, NREMT - I, CSCS, associate athletic director of sports medicine for the University of Georgia Athletic Association, and author of the NATA's statement.

Help Further Research on Adult Attachment Adult attachment has been found to be strongly associated with child psychological, socio - emotional, and behavioral outcomes.

Most studies of homebirth in other countries have found no statistically significant differences in perinatal outcomes between home and hospital births for women at low risk of complications.36, 37,39 However, a recent study in the United States showed poorer neonatal outcomes for births occurring at home or in birth centres.40 A meta - analysis in the same year demonstrated higher perinatal mortality associated with homebirth41 but has been strongly criticised on methodological grounds.5, 42 The Birthplace in England study, 43 the largest prospective cohort study on place of birth for women at low risk of complications, analysed a composite outcome, which included stillbirth and early neonatal death among other serious morbidity.

It largely focuses on colonization of the mother's vaginal tract and amniotic fluid with organisms that may be associated with poor outcomes * in pregnancy *, such as preterm labor.

Why bother doing more research on outcomes associated with breastfeeding?

We therefore performed each simulation 2,000 times, drawing key parameters at random from triangular distributions covering the range of estimates available in the literature associating breastfeeding with maternal health outcomes, centered on the point estimate provided in the literature and a distribution width of four standard errors.

Like so many things in life the truth is a bit complex: there is no one outcome (good or bad) that can be associated with cosleeping in the form of «bed - sharing, but rather a range of outcomes (from potentially beneficial to dangerous and risky) depending on the overall circumstances within which the cosleeping takes place.

Moreover, robust evidence on the cost effectiveness of birth in alternative settings is a priority, as was highlighted by the recent National Institute for Health and Clinical Excellence (NICE) clinical guidance on intrapartum care.11 The Birthplace in England research programme was designed to fill gaps in research evidence about the processes and outcomes associated with different settings for birth in the NHS in England.

Perinatal events can result in associated longer term health and broader societal costs, as shown by the size of damages paid in obstetric litigation cases, which represent a substantial cost to the NHS.27 Follow - up over weeks or longer to monitor recovery, or a future assessment of the outcomes for mothers and babies at a later date, would act as a vehicle for estimating costs and consequences beyond the perinatal period and shed more light on long term cost effectiveness.

Another strength is that our results provide a more complete assessment of socioeconomic inequalities in breastfeeding rates, by estimating both relative and absolute inequalities, than common practice in inequality assessments.23 Finally, our study analysed effects of the intervention not only on an immediate, direct outcome (breastfeeding) but also on a long - term consequence of breastfeeding (child cognitive ability) that is associated with important health and behavioural outcomes in later life.27

We used multiple regression to estimate the differences in total cost between the settings for birth and to adjust for potential confounders, including maternal age, parity, ethnicity, understanding of English, marital status, BMI, index of multiple deprivation score, parity, and gestational age at birth, which could each be associated with planned place of birth and with adverse outcomes.12 For the generalised linear model on costs, we selected a γ distribution and identity link function in preference to alternative distributional forms and link functions on the basis of its low Akaike's information criterion (AIC) statistic.

When we analysed the effects of planned place of birth on maternal outcomes, all shifts to non-obstetric unit settings were associated with significant cost savings and significant improvements in terms of maternal morbidity avoided (table 5 ⇓) or additional normal birth (table 6 ⇓).

Switching from planned birth in an obstetric unit to midwifery units was on average cost saving and associated with a non-significant decrease in adverse perinatal outcomes.

For the purposes of this economic evaluation, the forms were initially used in a related study funded by the National Institute of Health Research (NIHR) research for patient benefit programme «assessing the impact of a new birth centre on choice and outcome of maternity care in an inner city area,» which will be reported in full elsewhere, comparing the costs of care in a free standing midwifery unit with care in an obstetric unit in the same trust.16 The data collected included details of staffing levels, treatments, surgeries, diagnostic imaging tests, scans, drugs, and other resource inputs associated with each stage of the pathway through intrapartum and after birth care.

For low risk women without complicating conditions at the start of care in labour, the mean incremental cost effectiveness ratios associated with switches from planned birth in obstetric unit to non-obstetric unit settings fell in the south west quadrant of the cost effectiveness plane (representing, on average, reduced costs and worse outcomes).25 The mean incremental cost effectiveness ratios ranged from # 143382 (alongside midwifery units) to # 497595 (home)(table 4 ⇓).

These measures were chosen on the basis of being known to be associated with the mother's breastfeeding history and / or with the cognitive and academic outcomes.

Understanding the impacts home visiting programs have had on children's social and emotional development begins with identifying those programs that have affected antecedent risk and protective factors associated with child and emotional development in addition to specific social and emotional outcomes.

For continuous outcomes measured on different scales, we pooled standardised mean differences (SMDs) and associated 95 % CIs.

Enabling women to breastfeed is also a public health priority because, on a population level, interruption of lactation is associated with adverse health outcomes for the woman and her child, including higher maternal risks of breast cancer, ovarian cancer, diabetes, hypertension, and heart disease, and greater infant risks of infectious disease, sudden infant death syndrome, and metabolic disease (2, 4).

The American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal - Fetal Medicine (SMFM) stated that, «one of the most effective tools to improve labor and delivery outcomes is the continuous presence of support personnel, such as a doula... continuous one - on - one support during labor and delivery was associated with improved patient satisfaction and a statistically significant reduction in the rate of cesarean delivery».

Costs associated with a moderately morbid neonatal outcome, as well as the probabilities of infant morbidity occurring, heavily impacted our results.The cost - effectiveness of VBAC depends on the likelihood of successful trial of labor.

While father absence has been associated with a host of negative children's outcomes, including increased risk of dropping out of school and lower educational attainment, poorer physical and mental health, and behavioural problems,36 - 40 higher levels of involvement by nonresident fathers may assuage the negative effects of father absence on children's outcomes.41, 42 Quality of the parents» relationship before divorce, or of the pre-divorce father / child relationship, can also be an important factor: children fare worse following divorce when pre-divorce relationships were good and fare better when pre-divorce relationships were poor, 43,44 suggesting children are sometimes better off without a father if the father's relationship to the child or the mother was not good.

Moreover, data for exposures in almost all studies were based only on maternal recall, sometimes some years after the exposures, although studies have shown that mothers remember breastfeeding durations many years after breastfeeding has stopped.55 - 57 Furthermore, research shows that mothers of sick children sometimes remember early exposures of their children in greater detail compared with mothers of healthy children, especially when the exposures are publicly perceived to be associated with the outcome studied.

Many studies on nutrition have associated poor prenatal and early post-natal nutrition or malnutrition with a variety of developmental outcomes.

The Legislators also supports an explicit law that ensures school districts, individual schools, teachers and students are protected from any withholding of state funds, sanctions or negative impact on a teacher's evaluation associated with the outcomes related to test opt outs.

«We saw significant, worse prognoses and outcomes for women with a pregnancy - associated melanoma, compared to a control group of non-pregnant women,» said Brian Gastman, M.D., a plastic surgeon, director of melanoma surgery at Cleveland Clinic, and primary investigator on the study.

However, increased social spending per dollar spent on health care was associated with improved health outcomes at the population level by province.

Commenting on the study, Dr Kuehni said: «The study stands out from many others, in that it does not content itself with showing that putative risk factors and health outcome are associated (which means only that they occur more often together than would be expected by chance).

«While the presence of lymphocytes in tumors is often associated with better clinical outcomes, this research adds clarity on the diversity of T cells within the tumor environment and their influence on ovarian cancer outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.

While some research was previously done by his and other groups on a smaller scale, «This is the first real description of a method that could be used broadly across a range of conditions to operationally measure diagnostic errors and associated bad outcomes so that we can track our performance and see whether our interventions are making a difference,» Newman - Toker says.

While late - term gestation was associated with an increase in the rate of abnormal conditions at birth and with worse physical outcomes during childhood, it was also associated with better performance on all three measures of school - based cognitive functioning measures during childhood,» the study concludes.

Led by Joke Bradt, PhD, associate professor in Drexel University's College of Nursing and Health Professions, a team looked into studies that examined the impact of music therapy (a personalized music experience offered by trained music therapists) and music medicine (listening to pre-recorded music provided by a doctor or nurse) on psychological and physical outcomes in people with cancer.

«Using an algorithm based on genetic testing to guide treatment is sustainable and associated with better clinical outcomes in a real - world clinical practice, although it is difficult to consistently maintain,» said Craig R. Lee, Pharm.D., Ph.D., F.A.H.A., associate professor of pharmacy at the University of North Carolina at Chapel Hill Eshelman School of Pharmacy.

Timely administration of intravenous thrombolytics is associated with more favorable outcomes from ischemic stroke, but has not been shown to have significant effects on mortality.

«I think it is very positive that the plan sets aspirational goals associated with both reducing incidence in key populations and in achieving specific health outcomes for those needing treatment with an emphasis on reducing disparities.»

«By embedding mental health screening in the emergency department, we are making it part of our health care culture — reducing the stigma associated with mental health problems and providing the opportunity for early identification and treatment for all children,» said Jeffrey I. Gold, PhD, director of the Children's Outcomes, Research and Evaluation program at CHLA and an author on the study.

Some epidemiologic evidence suggests that arsenic exposure in utero and early in life may be associated with adverse effects on fetal growth, and on infant and child immune and neurodevelopment outcomes.

Kail said future research should focus on the distinctions between different forms of insurance and the generosity of coverage, as well as how these factors are associated with diverse health outcomes.

«Low levels of functional BRCA are associated with a greater number of clonal mutations and enhanced immune recruitment, which may explain the greater chemosensitivity of these tumors and better outcomes for patients,» explained Christos Hatzis, assistant professor of medicine and director of Breast Bioinformatics, Yale Cancer Center and senior author on the paper.

«Our goal is to raise overall awareness of military sexual trauma, including the impact on male veterans, and associated adverse outcomes such as homelessness,» Kimerling says.

Published in the New England Journal of Medicine on May 12, 2016, the study's findings suggest patients» illness severity, functional abilities, cognitive status and neuropsychological well - being are not associated with caregiver outcomes.