The labelling is for acetylated tubulin in red (identifying all axons), and green for the cell permeable dye calcein, which is only applied
on the axonal side of the chambers (top half) and allows the identification of those neuronal cell bodies (bottom half) that have extended axons to the other side of the microfluidic device.
In the absence of the Aβ challenge, tau reduction had no effect
on axonal transport.
Not exact matches
This new study builds
on previous research from this group showing that elevated blood levels of SNTF
on the day of a mild traumatic brain injury treated in the emergency room predicted those patients who would go
on to suffer diffuse
axonal injury and long - term cognitive dysfunction.
Most importantly, when their
axonal processes stretch out and connect to neighboring cells, they almost always do so at the same location
on that neuron — the axon initial segment — and nowhere else.
Guy McKhann of Johns Hopkins University in Baltimore, Maryland, began research
on what was to become known as AMAN (acute motor
axonal neuropathy)-- a type of GBS — in 1990 while
on a visit to Beijing pediatric hospitals.
When pathologists perform autopsies
on people with diffuse
axonal injury, they see severed axons with swollen tips, just like what Smith sees in his experiments.
Smith's findings could shed light
on a common but puzzling brain trauma known as diffuse
axonal injury.
Work in several laboratories has shown that the retrograde
axonal transport of NGF follows its interaction with specific receptor sites
on the nerve terminals of the newly established fibers.
We study the influence of the Maillard reaction (leading to advanced glycation endproducts, AGEs)
on the function of specific proteins which are involved in the
axonal transport.
AGEs impair this
axonal transport and alpha adrenergic blockers (acting
on cell «stress receptors») can exert a protection of this phenomenon.Thus, will look
on the molecular mechanisms of this process (crosslinking of motor proteins in
axonal transport, energy depletion etc.) by analyzing the colocalization of fluorescence staining of (motor --RRB- proteins and tagged AGE - molecules and by methods of molecular biology.
Scaling great walls When they both started at Penn, Lee had a project
on the effects of nerve growth factor
on PC12 cells, and Trojanowski was studying
axonal transport and endocytosis.
Maturation of the peripheral nervous system requires specification of
axonal diameter, which, in turn, has a significant influence
on nerve conduction velocity.
The pattern of RGC loss in patients as well as information obtained from laboratory research all point to the fact that an important site of pathology occurs at the optic nerve head, a region where the
axonal cell processes of RGCs exit the eye
on their way to the visual centers of the brain.
Preliminary analysis found that children from families living in poverty tended to have a smaller, less - developed hippocampus with fewer
axonal connections with the PFC..
On further analysis, the authors determined that it wasn't poverty itself that was associated with a less - functional hippocampus.
i) The injury shows positive findings
on a computerized axial tomography scan, a magnetic resonance imaging or any other medically recognized brain diagnostic technology indicating intracranial pathology that is a result of the accident, including, but not limited to, intracranial contusions or haemorrhages, diffuse
axonal injury, cerebral edema, midline shift or pneumocephaly.
i) The insured person is accepted for admission,
on an in - patient basis, to a public hospital named in a Guideline with positive findings
on a computerized axial tomography scan, a magnetic resonance imaging or any other medically recognized brain diagnostic technology indicating intracranial pathology that is a result of the accident, including, but not limited to intracranial contusions or haemorrhages, diffuse
axonal injury, cerebral edema, midline shift or phneumocephaly.
... experienced a severe head injury
on July 31, 2010 which resulted in extensive post traumatic imaging findings including grade 1 and 2 diffuse
axonal injury, subarachnoid hemorrhage including involvement of basal cisterns, intraventricular hemorrhage, multiple subdural hematomas, small epidural hematoma and left frontal and bilateral temporal hemorrhagic contusions.