Sentences with phrase «on blood cells in»

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

Not exact matches

Weeks later, Yee realized that he didn't have the equipment he needed to pluck out of Ziskin's blood the rare (perhaps one in 100,000) T cells that could identify the subtle peptide markers on the surface of her cancer cells and attack the disease.

This new kind of approach to fighting blood cancers is truly personalized; immune T - cells are extracted from patients, genetically tinkered to home in on an destroy cancerous cells, multiplied in a lab, and then jolted back into the patient's body within about two weeks.

In diseases such as malaria and sickle cell disease, red blood cells break down, with harmful effects on the rest of the body — particularly the lining of small blood vessels.

And if you don't deny it, then why discredit the fact that food, the very substance that all humans need in order to keep organs functioning, blood pumping, toxins dispelling, cells forming, could be causing severe effects on our health if the wrong foods are eaten?

Studies have shown that chlorophyll found in food or small purified amounts of chlorophyll have a favorable effect on red blood cell formation in the bone marrow.

When swelling, bleeding or other products of inflammation occur inside a compartment, the increase in pressure on the capillaries, muscles and nerves can result in intense pain and loss of oxygenated blood to the muscle and nerve cells.

On the walls of the lactocytes (milk - producing cells of the alveoli) are prolactin receptor sites that allow the prolactin in the blood stream to move into the lactocytes and stimulate the synthesis of breastmilk components.

The study, published 13 June 2013, focused on two serious adverse events: postpartum hemorrhage and manual removal of the placenta, both of which are life - threatening, and also included admission to intensive care, eclampsia, and more than four packed cells in a blood transfusion.

The blood type is found as proteins on red blood cells and in body fluids.

However, the use of the question on consumption of oily fish as an indicator of maternal DHA status is supported by the correlation between the frequency of intake of oily fish with the amount of DHA in the maternal red blood cell membranes (Figure 1).

Much of the research on CD8 + T cells has focused on studying them in the circulating blood, which has a dominant phenotype of CD8αβ +.

But is it fair to equate historical constraints with defects in describing how vertebrate photoreceptors are on the back of the «inside - out» retina, shadowed by blood vessels and overlying cells?

This elusive stability must be achieved before stem cell supplies can be kept on hand until it is time to turn them into replacements for say misshapen red blood cells seen in sickle cell anemia or abnormal white blood cells causing leukemia.

«After already being able to demonstrate the influence of prenatal smoking on regulatory T - cell numbers in cord blood from our LINA study, the current epidemiological investigation delves even deeper into molecular processes,» Dr. Gunda Herberth and Dr. Irina Lehmann resume.

By hindering LMPTP, the drug reawakens insulin receptors on the surface of cells — especially in the liver — which normally absorb excess sugar from the blood when they detect insulin.

The team tested the technique on cells in culture that mimic the transformation of unspecialised white blood cells into full immune cells.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

Somewhere, they mused, a mosquito that fed on a dinosaur might be trapped in amber, and white blood cells from the dinosaur might be preserved in the mosquito's stomach.

The study, recently published in Cell Metabolism, also found that beige fat, unlike the better - known white and brown fat, has interesting anti-diabetic effects on blood sugar metabolism that seem independent of temperature regulation.

Prostate cancer risk groups are assigned based on the prostate biopsy results, which include the Gleason score (GS)-- an indication of how aggressively the tumor cells may behave — and the prostate specific antigen (PSA) level in the patient's blood at the time of diagnosis.

This is how treatments based on a type of white blood cell called T - cells are curing some cancers, rather than just slowing their advance (see «Cancer meets its nemesis in reprogrammed blood cells «-RRB-.

They focused on the role of monocytes, immune cells that normally pass along the blood vessels and in response to a local infection move quickly into the affected organ and contribute to the localized immune defense there.

After imaging defiant metastatic cells in the brains of mice, researchers noticed that the cells that were able to survive grew on top of blood capillaries, each cell sticking closely to its vessel «like a panda bear hugging a tree trunk,» Dr. Massagué says.

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

They specifically studied the length of telomeres (repeated DNA sequences) on the ends of chromosomes in leukocytes (white blood cells); the protective caps are believed to be markers of biological aging, because they shrink over time.

A paper published online in the 27 January issue of Nature shows that people on ARVs who appear to completely suppress the virus in their blood have new HIV being made in their lymph node cells — which may be refilling the reservoir.

A skin biopsy on the girl's larger leg found 5 % of cells in that sample had the same abnormality, even though her blood sample was clean.

In people with sickle cell anemia, molecules of sickle hemoglobin clump together and form long rods that cause red blood cells to become rigid and take on a sickle shape.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiplIn experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiplin cancer stem cells that prompt leukaemic blood cells to multiply.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vesselIn experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vesselin mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

Rahul Palchaudhuri, a postdoctoral fellow in Scadden's lab and first author on the paper, armed CD45 - targeting antibodies with a payload that destroys only existing blood cells.

By analyzing chemical changes of the IRS - 2 protein in immortalized cultures of human white blood cells, it determined that IRS - 2 appeared in two different forms — «on,» which allows the signal to pass through, and «off,» which stops the signal from activating the cells into M2 macrophages.

The first - ever study of radiation exposure on wild primates, conducted in 2012, found that monkeys near Fukushima had significantly lower red and white blood - cell counts compared with monkeys elsewhere in Japan.

The vibrations create a standing wave that deflects cells in the blood to a different degree depending on their...

I couldn't resist composing this after the mention of the charmingly misspelled word «hematopoetic» in your story on blood grown in the lab from stem cells (12 November, p 8):

The researchers then took naïve immune cells — which transform into different types based on the invaders they encounter — from the blood of healthy individuals and exposed them to bacteria in the guts of MS patients.

The insulin these cells produced acted on blood sugar levels in the same way as insulin from the pancreas.

Modern brain - imaging techniques that track blood flow and cell activity indicate the precuneus is involved in imagination, self - consciousness and reflecting on memories.

Cloaked in a red blood cell sheath, more than 3,000 of these toxin - hungry nanosponges can slide through the bloodstream on the prowl for poisonous material.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

And the cells in our body differ from one another — serving as neurons, white blood cells, smell sensors, and so on — largely because they activate different sets of genes and thus produce different mixtures of proteins.

Pediatric immunologists Gurjit Khurana Hershey and Talal Chatila of the Washington University School of Medicine in St. Louis and their colleagues set out to examine the receptor protein that IL - 4 binds to on white blood cells.

Analyzing immune cells in umbilical cord blood from 1074 infants, Zhang and colleagues found that babies who showed hyperactive innate immune responses at birth went on to develop a food allergy when tested at age one.

It is based on a series of biochemical reactions that detect DNA damage in human blood cells.

Therefore, they must explore the effects of deactivating it on the body's ability to fight infections and other diseases — as hampering the gene's effects only in red blood cells would be difficult.

«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve tissue,» said Zhang.

Most importantly, the doxorubicin - decorated diamonds had no effect on white blood cell count, an indicator of immune system activation that's often the deciding factor in whether a patient can continue chemotherapy.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.