Sentences with phrase «on bone marrow cells»

The investigators also discovered that neutrophils secrete a molecule called S100A8 / S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marrow cells.

Not exact matches

Studies have shown that chlorophyll found in food or small purified amounts of chlorophyll have a favorable effect on red blood cell formation in the bone marrow.

Rocco Bavuso, left, 22, of Bayside, who was diagnosed with aplastic anemia, meets Christian Verholen, 32, his marrow doner, on May 8, 2018, at the annual Celebration of Life Dinner of North Shore University Hospital's Don Monti Bone Marrow and Stem Cell Transplantation Program at Crest Hollow Country Club in Woomarrow doner, on May 8, 2018, at the annual Celebration of Life Dinner of North Shore University Hospital's Don Monti Bone Marrow and Stem Cell Transplantation Program at Crest Hollow Country Club in WooMarrow and Stem Cell Transplantation Program at Crest Hollow Country Club in Woodbury.

On to the blocks were poured a mixture of recombinant human bone morphogenic protein (BMP) powder — a genetically engineered protein that causes cells to ossify or become bone — and liquid bone marrow containing stem cells.

Wagers was inspired to research bone marrow stem cells and did her postdoctoral work on adult stem cells.

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

«Blood stem cell self - renewal dependent on surroundings: Blood formation: Bone marrow, blood stem cells work in close harmony.»

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

To gauge the effect off the loss of imprinting control on the maintenance of the quiescent hematopoietic stem cell pool, Venkatraman analyzed the numbers of quiescent, active and differentiated hematopoietic stem cells in mouse bone marrow.

Given that breast cancer cells traveling through the bloodstream on their way to secondary sites where breast tumors metastasize most often — lung, bone marrow, brain and liver — must first pass through the basement membrane microvasculature, Ghajar and Bissell suspected that the basement membrane could be a major component of the dormant niche in distant organs.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.

Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of the bone marrow microenvironment.

«Because the hematopoetic stem cell niche is so important for the creation of bone marrow and blood cells and because Del - 1 is a soluble protein and is easily manipulated, one can see that it could be a target in many potential applications,» said George Hajishengallis, the Thomas W. Evans Centennial Professor in the Department of Microbiology in Penn's School of Dental Medicine and a senior author on the work.

Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.

«The dose of transplanted bone marrow has strong and lasting effects on how HSCs specialize and coordinate their behavior,» said Rong Lu, senior author and assistant professor of stem cell biology and regenerative medicine.

They then used human stem cells derived from bone marrow that would normally become bone cells to test the effects of the nanoparticles on stem cell proliferation and differentiation.

The second branch of the combination therapy, the low - dose metronomic chemotherapy, was similarly found to exert its therapeutic effect through a novel, hitherto unrecognized mechanism: The metronomic chemotherapy turned out to not primarily target the tumor cells, but to act on the recruitment of yet another tumor - promoting cell population from the bone marrow.

Our previous study showed that microneedle vaccination induced higher levels of antibody - secreting cells in spleen and bone marrow compared to intramuscular vaccination,» says Sang - Moo Kang of Georgia State University, a researcher on the study.

The two cell types formed structures reminiscent of bone growth plates — cartilage on one side, bone and marrow on the other, they report online 6 September in the Proceedings of the National Academy of Sciences.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

The so - called Stamina method is a treatment based on bone marrow stem cells that Stamina's President Davide Vannoni claims can grow new neurons under specific conditions and hence cure several neurodegenerative diseases.

The Bundesrat approved the revisions on 10 July, just over two weeks after the German Society for Neurology and the German Parkinson Society issued a joint statement warning that patients with Parkinson's disease should not undergo treatments involving bone marrow stem cells.

Impact of bone marrow - derived mesenchymal stem cells on remodeling the lung injury induced by lipopolysaccharides in mice Mouchira M Mohi El - Din, Laila A Rashed, Mohi A Mahmoud Haridy, Atef Mohamed Khalil, Mohamed A Mohamed Albadry.

Effects of the chemokine stromal cell - derived factor - 1 on the migration and localization of precursor - B acute lymphoblastic leukemia cells within bone marrow stromal layers.

Co-culture of bone marrow fibroblasts and endothelial cells on modified polycaprolactone substrates for enhanced potentials in bone tissue engineering.

Skeletal muscle fiber formation, bone marrow stem cell formation, thymus T - cell formation, TNF - a / INF - gamma production by immune system's macrophages (immunosenescence by IGF loss), neuregulin and brain - derived neutrophic factor depend on IGF - 1 acting on brain IGFR receptors.

Porcine bone marrow stromal cell differentiation on heparin - adsorbed poly (e-caprolactone)- tricalcium phosphate - collagen scaffolds.

These findings are in agreement with other studies on cell morphology [3, 4] and senescence [5], and the authors hope to advance these studies by separately analyzing subpopulations derived from the same bone marrow sample, and also surveying the grade of cell maturity (surface receptor analysis) and cytoskeleton composition of the cells during cell tracking.

In an outpatient blood and bone marrow stem cell transplant, the patient undergoes the full course of treatment (pre-transplant evaluation, conditioning, infusion of their stem cells, engraftment and recovery) on an outpatient basis rather than being admitted to the hospital for three to four weeks of treatment.

Since 2005 his group is working on the immunomodulatory activities of human mesenchymal stem cells isolated from different sources — bone marrow, adipose tissue, endometrium, decidua.

To highlight the potentially important role of 3D culture conditions, the authors compared 2D monolayers of hepatocyte progenitors, fetal liver stromal cells, or adult bone marrow - derived stromal progenitor cells to their 3D counterparts cultured on liver extracellular matrix (3D - ECM) constructs.

A. Whether the treatment is offered in the hospital or on an outpatient basis, patients and their families receive thorough support and education to prepare for all phases of the blood and bone marrow stem cell transplant process.

Since 1995, Dr. Maharaj has been applying his academic experience and performing evidence - based chemotherapy treatment and bone marrow stem cell transplant procedures on a completely outpatient setting, with the main purpose of improving patients» safety by minimizing the risks of mortality associated with hospital - acquired infections and, ultimately, improving quality of life.

We offer a full spectrum of treatment services on site, including chemotherapy and radiation therapy, pre - and post transplant care for blood and bone marrow stem cell transplantation, as well as cancer screenings and supportive care services such as patient support groups and a cancer resource center.

Bone marrow - derived mesenchymal stem cells (BM - MSCs) are obtained by isolating mononucleated cells from a marrow aspirate by centrifugation on a density gradient, followed by adherent cell expansion in tissue culture.

VCAM - 1 binds to VLA - 4 on bone marrow progenitor cells.

Until now, blood cell production was ascribed solely to bone marrow, but studies on mice have found that the majority of the body's platelets are produced in the lungs, as is a backup reservoir of blood stem cells that can step in when those in the bone marrow run dry.

On day 0, recipient mice were transplanted with 5 × 106 T cell — depleted bone marrow (TCD - BM) cells and 1 × 106 spleen T cells from B6 donors.

We describe in this study anti-BTLA mAbs that demonstrate that the protein is expressed in the bone marrow and thymus on developing B and T cells, respectively.

Background In our institute, the first research program on disseminated tumor cells (DTC) detection in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005).

Our physicians and scientists are working on a number of initiatives, including collecting blood and bone marrow from patients to better understand the causes of bone marrow failure syndromes and MDS; exploring possible genetic factors that guide medical care; collecting blood and bone marrow to identify specific proteins that are faulty and how these defects relate to clinical complications and outcomes; and clinical trials to improve stem cell transplants for disorders such as dyskeratosis congenita.

This work, published in «Blood», was carried out by the CNIO Telomeres and Telomerase Group The treatment is based on the transport of the telomerase gene to the bone marrow cells using gene therapy, a completely new strategy in the treatment of aplastic anaemia

Quyyumi says the research team checked whether patients» pre-existing levels of CD34 + cells in their bone marrow had a significant effect on their outcomes; they did not.

Another is to monitor the effects of transplanting telomerase - deficient but ex vivo telomere - extended bone marrow into late - generation, TMM - disabled mice, so as to be certain that the niche of such animals (or, by implication, aging humans) will support the homing, engraftment, and initial development and differentiation of such cells; the necessary research is underway now thanks to a SENS Foundation grant to Dr. Zhenyu Ju of the Institute of Laboratory Animal Sciences and Max - Planck - Partner - Group on Stem Cell Aging in the Chinese Academy of Medical Sciences, and research partner of prominent telomere biologist Dr. K. Lenhard Rudolph.

The impetus obtained from earlier studies on these rats demonstrates an inflammatory milieu peaking between 6 and 9 months of age in adipose, pancreas, and bone marrow / mesenchymal stem cells.

Our initial studies were on characterization of different adult neural stem cell types from murine and human brain and human bone marrow.

The published research on Regenexx procedures accounts for approx. 50 % of the world's orthopedic stem cell literature (cumulative n of patients published & treated with bone marrow stem cells as of 7/1/2017)

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.