In a report on the mouse studies, published online Sept. 11 in PNAS (Proceedings of the National Academy of Sciences of the United States of America), the investigators say the genetic alteration appears to release the biochemical «brakes»
on brain cells involved in body movement, reasoning and perception of the world, triggering over-excited activity and reactions.
Not exact matches
Chemogenetics builds
on optogenetics, which
involves genetically engineering
brain cells so that they fire in the presence of light.
Modern
brain - imaging techniques that track blood flow and
cell activity indicate the precuneus is
involved in imagination, self - consciousness and reflecting
on memories.
A month after H7N7 or H3N2 infection, mice had fewer nerve
cell connectors called dendritic spines
on cells in the hippocampus, a
brain region
involved in memory.
He examined the direct impact of the substance
on neural effects using tests
involving brain cells.
In addition, the two genes are turned
on in areas that are part of the cortico - striatal - thalamo - cortical circuit, a loop of
brain cells connecting the cortex to specific regions
involved in processing emotions and movement.
Building
on that work, the current paper looked at a less lethal strain, the H1N1 «swine flu,» that does not infect neurons, but which, the researchers showed, still caused inflammation in the
brain via inflammatory chemicals or cytokines released by immune
cells involved in fighting the infection.
Although what drives this process has not been clear, studies have indicated that caspace - 2 might be
involved, according to senior author Michael Shelanski, MD, PhD, the Delafield Professor of Pathology &
Cell Biology, chair of the Department of Pathology &
Cell Biology, and co-director of the Taub Institute for Research
on Alzheimer's Disease and the Aging
Brain at CUMC.
• Kappa opioid receptor, a protein
on the surface of
brain cells that is centrally
involved in pleasure as well as in pain, addiction, depression, psychosis and related conditions.
Ultimately, the combination of this new method of focusing
on gene activity in single
cells with other single -
cell techniques
involving microscopic imaging is likely to reveal the origins of developmental disorders of the
brain, he added.
Summary of a panel discussion
on stem
cells and the aging
brain involving a world - leading grouping of international stem
cell scientists.
The challenge takes
on even more urgency with recent developments, including a federal administration now more open to exploring the potential of stem
cells, the recent FDA approval of a human trial
involving embryonic stem
cells, as well as the reported case of a young boy who developed a
brain tumor four years after receiving a stem -
cell treatment for a rare genetic disorder.
In the 2007 - 2008 academic year, for instance, awards supported research
on topics such as the imaging of
brain regions
involved in the learning of words, the relation between memory and the growth of
brain cells in adulthood, the neural activity behind birdsongs and the processing of sensory data in the
brains of infants at risk for autism.
The work in humans is complemented by laboratory work
involving cell death in Parkinson's disease, effects of stimulation
on hippocampal neurogenesis and animal models of deep
brain stimulation.
Using genetic tools to turn
on and off different parts of the
brain, the scientists were able to identify specific
brain circuits and neurons (
brain cells)
involved in the food coma experience.
Nevertheless, these observations are consistent with the notion that T
cells will be informative not only
on immune specific genes that are associated with the HPA axis but also
on some genes that are also
involved in
brain function.