Sentences with phrase «on cancer cells by»

In the early 1990s, in vitro tests on cancer cells by Lane and his colleagues hinted that some compounds could restore mutant p53's normal function.

Not exact matches

Since God does not have a monopoly on power, God's will - and consequently God's response to prayers consonant with the divine will - can be and sometimes is thwarted by the recalcitrance of non divine actualities, whether persons or cancer cells.

Phytic acid's chelating effect may serve to prevent, inhibit, or even cure some cancers by depriving those cells of the minerals (especially iron) they need to reproduce.17 The deprivation of essential minerals like iron would, much like other broad treatments for cancer, also have negative effects on non-cancerous cells.

The study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular Cell, reveals why loss of the PTEN gene has such an impact on many people with prostate cancer, as well as in some breast cancers.

TruePrime LB addresses current liquid biopsy sensitivity and specificity issues by using adapted amplification of cancer - specific, large - fragment, cell - free DNA based on primer - free technology that combines the enzymes TthPrimPol and Phi29 DNA polymerase.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

The removal of these components might be expected to unleash an assault by the immune system on cancer cells left after surgery.

Targeted cancer treatments are designed to attack molecules produced by mutations, but if the targeted mutation occurs on an evolutionary branch and not the trunk, the treatment will fail as other branches dominate and treatment resistant cells spread.

Lab testing showed that the plant - made virus particles, which naturally bind to receptors on cancer cells, were taken in by human breast cancer cells.

In collaboration with Prof. Dr. Roland Schüle and his team at the Center of Clinical Research of the Freiburg University Medical Center, the scientists were able to test several epigenetic inhibitors that had been newly developed by Schüle and his team on the cancer stem cell model.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

The biomarker panel, enabled by discovery work of first author Jungsun Kim, PhD, a postdoctoral fellow in Zaret's lab, builds on a first - of - its - kind human - cell model of pancreatic cancer progression the lab described in 2013.

In testing on two mouse cell lines, the drug combination reduced the viability of cancer cells by about 50 percent when compared with everolimus alone, according to the findings.

Most cancer chemotherapy relies on cells absorbing drugs by diffusion across the cell membrane.

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking thCancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking thCancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking thcancer that no longer responded to standard hormone - blocking therapy.

The gold - iron oxide core - shell nanorods may be useful in cancer therapy, with MRI imaging enabled by the iron oxide shell, and local heating created by the photothermal effect on the gold nanorod core killing cancer cells.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

To date, it was assumed that chloroquine increases the sensitivity of cancer cells to chemotherapy by means of a direct effect on the cancer cells.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

By switching Apc on, researchers turned swelling mobs of mouse cancer cells (above) back into normal intestinal tissue (below).

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

Professor Gianni Liti, a senior author on the paper from the Institute for Research on Cancer and Ageing, Nice, said: «We were able to study the evolution in time by combining genome sequences of the cell populations and tracking the growth characteristics of the yeast cells.

Based on the pioneering work of Dr. Claire Lugassy and Dr. Raymond Barnhill at UCLA's Jonsson Comprehensive Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) Cancer Center, a new study provides additional support for a process by which melanoma cells, a deadly form of skin cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) cancer, can spread throughout the body by creeping like tiny spiders along the outside of blood vessels without ever entering the blood stream, and that this process is exacerbated by exposure to ultraviolet (UV) light.

This analysis, done on separate samples from the same patient, revealed that many of the affected genes confer advantages to cancer cells by, for example, enhancing cell migration or resistance to chemotherapy.

They elaborate on several focus areas described by the White House earlier: preventive vaccines, early detection, single cancer cell genomics, immunotherapy, pediatric cancer, and data sharing.

With this context, the new study tested an approach based on the idea that if prostate cancer cells were flooded with testosterone, the cells might be killed by the hormone shock.

A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer.

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases and found that a molecule named IL13RA2 (IL13R alpha2) was abundant in metastatic or late - stage BLBC.

In fact, depending on the tumor cell, they grow at dramatically different speeds, according to a study led by Nicholas Navin, Ph.D., assistant professor in the Department of Genetics at The University of Texas M.D. Anderson Cancer Center in Houston.

Olaparib had no effect on tumors formed by breast cancer cells containing functional BRCA1 and BRCA2 genes.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

But cancer cells keep on going by deploying one of two strategies to reconstruct telomeres.

«These findings build on a long history of work in our laboratory investigating mechanisms by which cancer cells respond to environmental stresses,» says Grant.

Based on an analysis of existing evidence, published in an opinion article in the Nature Reviews Clinical Oncology journal on January 20, Dr. Narod argues that to achieve a cure, rather than simply delay progression or reoccurrence of the disease, women should be first treated with aggressive surgery to remove all clinically - detectable cancer cells, followed by targeted chemotherapy to the abdomen (intraperitoneal chemotherapy).

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

They prepared a similar weapon against liver cancer by piggybacking rhenium 18 on antibodies that target HBx, a viral antigen made by cancerous liver cells.

«Although right now we are focusing on developing a cancer vaccine, in the future we could be able to manipulate which type of dendritic cells or other types of immune cells are recruited to the 3D scaffold by using different kinds of cytokines released from the MSRs,» said co-lead author Aileen Li, a graduate student pursuing her Ph.D. in bioengineering at Harvard SEAS.

For several years, the research team from the Turku Centre for Biotechnology lead by Professor Johanna Ivaska has focused their efforts on understanding how cancer cells move and invade surrounding tissue.

The idea is that the drug, being within the nano - hydrogels, is transported directly to cancer cells where it can be released without damaging other parts of the body, because hydrogels offer the possibility of dosing a myriad of active substances on the site desired and can be administered as dry or swollen hydrogels by different routes: oral, nasal, buccal, rectal, transdermal, vaginal, ocular and parental.

«The current study was designed to determine the effect of inhibition of platelet activation and function by aspirin therapy on colon and pancreatic cancer cell proliferation,» the researchers wrote.

Dr Bernardo Tavora, lead author on the paper from the Barts Cancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothCancer Institute, said: «This work shows that sensitivity to cancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer treatment is related to our own body mistakenly trying to shield the cancer from cell - killing effects caused by radiotherapy and chemothcancer from cell - killing effects caused by radiotherapy and chemotherapy.

The breakthrough, published online today and featured on the cover of the journal Cell Reports, was led by Mick Bhatia, director of the McMaster Stem Cell and Cancer Research Institute.

While transplantation of T cells alone had only little impact on tumor size in cancerous mice, the researchers achieved substantial regression of the cancer by transplanting both T cells and activated eosinophils.

Because diseases such as cancer tend to evade detection by T - cells» receptors, allowing a tumor to grow unchecked, scientists have long sought «intel» on this process as a means of developing therapies that target malignant cells, but leave healthy cells alone.

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

Silver says her lab will try to build such a cell that they can then implant into mammals to detect and report on the extent of harm caused by UV radiation, which damages DNA and is a risk factor in the development of cancer.

They work by sticking to specific proteins found on the surface of cancer cells, flagging them up to be killed by the immune system.

By engineering red blood cells to have «sticky» proteins on their surface, a team of researchers has given the cells the ability to carry anything from drugs to treat immune disorders or cancer to radioactive molecules used in imaging of blood vessels.

University of Michigan, Ann Arbor, stem cell researcher Sean Morrison, an outspoken proponent of allowing research on human embryonic stem cells (hESCs) in the state, has been wooed to Texas by its $ 3 billion state cancer research program.