The relative contribution of intrinsic (e.g. genetic) and extrinsic (e.g. environmental) risk factors in cancer development is the subject of a paper published in the journal Nature, which reports that external risk factors have a greater influence
on cancer risk compared to intrinsic risk factors which only contribute modestly.
Not exact matches
«All vegetarians together had
on average a 22 per cent reduction in the
risk of developing colorectal
cancer,
compared with non-vegetarians,» said Orlich.
Using genome data from more than 50,000
cancer cases and 60,000 controls through the GAME -
ON (Genetic Associations and Mechanisms in Oncology) network, the team
compared telomere lengths with the
risk of developing breast, lung, colorectal, ovarian and prostate
cancers, including subtypes.
Japanese women have a longer menstrual cycle — about 32 days
on average,
compared to the 26 to 29 days that is typical in Britain — and a quarter of the
risk of breast
cancer.
The data for the current analysis
compared the effect of selenium and vitamin E, taken either alone or combined,
on prostate
cancer risk among 1,739 men who were diagnosed with prostate
cancer and, for comparison purposes, a random sample of 3,117 men without prostate
cancer who were matched to the cases by race and age.
Larsen will present the study, «Short and Long - Term
Risk of Congestive Heart Failure in Breast
Cancer and Lymphoma Patients
Compared to Controls: an Epidemiologic Study,»
on Saturday, March 10.
The researchers looked at the
risk of developing cervical
cancer between the ages of 61 and 80 depending
on the women's screening history when in their 50s, and
compared the
risk of developing cervical
cancer depending
on if the women had been screened after the age of 60 or not.
When tested
on 335 high -
risk lesions, the model correctly diagnosed 97 percent of the breast
cancers as malignant and reduced the number of benign surgeries by more than 30 percent
compared to existing approaches.
Worldwide, lung
cancer is the most commonly diagnosed form of
cancer.1 In the United Kingdom, its annual incidence is second only to that of breast
cancer, accounting for around 39000 new
cancer diagnoses annually.2 In countries that have seen a high prevalence of smoking, around 90 % of diagnoses of lung
cancer are attributable to cigarette smoking.3 The increased incidence from smoking is proportional to the length and intensity of smoking history.4
On average, a lifetime smoker has a 20-fold increase in the
risk of developing lung
cancer compared with a lifetime non - smoker.1 Lung
cancer is more common in men than in women, closely following past patterns of smoking prevalence, and 80 % of cases are diagnosed in people aged over 60.2
The WHO's argument rests
on epidemiological evidence from industrial and occupational exposure, populations that have been exposed to 10 - 1000 times the concentrations of TCDD
compared to the general population.4 While admitting the absence of a strong case for the elevation of any specific
cancer, they have compiled four major cohort studies to find a 40 percent increased
risk for all
cancers combined for «highly exposed» workers, the definition of which differed between studies.
Four studies failed to demonstrate an inverse association with colorectal
cancer, while a fifth found that people who consumed the equivalent of 2.5 cups of crucifers per week had a decreased
risk of colon
cancer but an increased
risk of rectal
cancer compared to those who consumed the equivalent of one - half cup per week.2 A pooled analysis of eight studies
on the relationship between fruit and vegetable consumption and breast
cancer showed no relationship with crucifers.25 None of four studies showed an inverse association with prostate
cancer, but one of them found a 28 percent reduced
risk for the consumption of five servings of crucifers per week
compared to one serving per week when they limited the analysis to men who were diagnosed with the prostate specific antigen (PSA) test, which is considered a more sensitive diagnostic measurement.
Among these studies are studies
on more than 19,000 children representing of 47,000 patient years of growth hormone treatment; a prospective study of 100 adult growth hormone — deficient patients followed for 1 to 4 years, a study of 910 children treated with growth hormone for 11 years, a study of 32 adults and children followed for up to 40 years treated with growth hormone (average 10.8 years); a study of 180 growth hormone — treated children followed for over 6 years with reduced
cancer recurrence
risk (RR 0.6); a prospective analysis of 289 growth hormone — deficient adults who, after 5 years of growth hormone therapy, showed lower
risk of malignancy (RR 0.25) and decreased
risk of myocardial infarction (RR 0.19) and early mortality (RR 0.22)
compared with the untreated group.
On September 24, 1907, the New York Times published an article entitled «
Cancer Increasing among Meat Eaters,» which described a seven - year epidemiological study showing that meat - eaters were at high cancer risk, compared with those choosing other st
Cancer Increasing among Meat Eaters,» which described a seven - year epidemiological study showing that meat - eaters were at high
cancer risk, compared with those choosing other st
cancer risk,
compared with those choosing other staples.
Diabetics who take insulin
compared to those
on oral medications almost double their
risk of
cancer.
A review of 40 studies
on gastrointestinal
cancers found a 21 to 43 percent lower
cancer risk with high intake of whole grains
compared to low intakes.21 Although studies examining the
risk of hormone - dependent
cancers are limited, the same review found that subjects in the highest category of whole grain intake had a 10 to 45 percent lower
risk of endometrial
cancer and a 37 to 40 percent lower
risk for ovarian
cancer.21