Sentences with phrase «on cancer stem»

Moreover, the inhibitory effects of niclosamide on cancer stem cells provided further evidence for its consideration as a promising drug for cancer therapy.

The results show that they both have an effect on cancer stem cells.

They have also developed other analogues that show very good inhibitory effects on cancer stem cells.

The researchers have isolated the sesquiterpene lactone damsin from the plant and studied its effect on cancer stem cells in three different breast cancer cell lines.

In the context of the current study, the researchers have developed a pre-clinical model system that specifically captures the impact of a treatment on cancer stem cells.

In collaboration with Prof. Dr. Roland Schüle and his team at the Center of Clinical Research of the Freiburg University Medical Center, the scientists were able to test several epigenetic inhibitors that had been newly developed by Schüle and his team on the cancer stem cell model.

Researchers measure the impact on cancer stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug.

Not exact matches

His research has spanned hematopoiesis, gene therapy, stem cell biology, genomics and cancer, consistently focusing on bringing the very latest research advances to patients with heretofore incurable diseases.

I mean, if god wants him to live he wouldn't have given him cancer in the first place but lets just say he contr.acted can.cer on his own but was called upon god to do these good dee.ds but needed more time, now what if the only way he could survi.ve was from stem cell res.earch?

Then a Columbia University doctor who specialized in the rare form of cancer that stems from exposure to asbestos, said he understood Silver's message to mean that he wanted to be a «rainmaker» at Weitz & Luxenberg, which was getting rich suing on behalf of mesothelioma victims.

Lab - grown tissues derived from patients» stem cells may also allow researchers to screen drugs and test their effectiveness on diseases like cancer.

Balboni's interest in religion and spirituality stems from her work on a psychosocial study called «Coping with Cancer,» which began in 2002 when she graduated from medical school.

Now Vermeulen's team has found that all colon cancer cells may have the potential to revert to stem cells and that whether they do depends on their environment.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

«As scientists, we have focused a good deal of attention on understanding the role of stem cells in the development of cancers, but there hasn't been a focus on mature cells,» said senior investigator Jason C. Mills, MD, PhD, a professor of medicine in the Division of Gastroenterology.

«If cancer recurs, it may be because the therapy didn't hit key mature cells that take on stem cell - like behavior.

Future research should not only compare how embryonic stem cells, iPS cells and adult stem cells differentiate, but focus on what effects the niche in which these cells will reside, when transplanted, will have on their characteristics, including tendencies to mutate into cancer cells, notes cell and stem cell biologist Olga Genbacev at the University of California, San Francisco, (U.C.S.F.) School of Medicine.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

On the other hand, the emergence of new products such as drugs for cancer, HIV / AIDS, and rare diseases, as well as progress in stem cell research, are strong positives in the industry's favor.

Although few women with HPV go on to develop cervical cancer, almost all cases of the disease stem from an infection.

These include the ability to bring new, innovative products to the market; progress in oncology, such as the approval of Genentech's drug Avastin for breast cancer and advances in the use of gene therapy, despite some setbacks; continuing progress in research on stem cells; the emergence of treatments for previously untreated diseases; and solutions for food and fuel shortages, such as biocrops and biofuels.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

Scientists from the German Cancer Research Center (DKFZ) have developed a way to equip mouse blood stem cells with a fluorescent marker that can be switched on from the outside.

«We began with stem cells taken from cord - blood, which have fewer acquired mutations and little, if any, epigenetic memory, which cells accumulate as time goes on,» says Zambidis, associate professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

The team used five types of antibiotics — including one used to treat acne (doxycycline)-- on cell lines of eight different types of tumour and found that four of them eradicated the cancer stem cells in every test.

When Kaufman, Zon and colleagues looked to see what was different about these early cancer cells, they found that crestin and the other activated genes are the same ones turned on during zebrafish embryonic development — specifically, in the stem cells that give rise to the pigment cells known as melanocytes, within a structure called the neural crest.

Co-authors on the study were Christian Mosimann (University of Zürich), Zi Peng Fan (Whitehead Institute and MIT), Justin Tan (Genome Institute of Singapore), Richard White (Memorial Sloan Kettering Cancer Center), Dominick Matos (Massachusetts General Hospital), Ann - Christin Puller (University Medical Center Hamburg - Eppendorf, Germany), Eric Liao (Harvard Stem Cell Institute and MGH) Richard Young (Whitehead Institute and MIT), and, at Boston Children's Hospital, Song Yang, Andrew Thomas, Julien Ablain, Rachel Fogley, Ellen van Rooijen, Elliott Hagedorn, Christie Ciarlo and Cristina Santoriello.

As an example, he cited his previous research on baked purple potatoes that have compounds that help suppress chronic intestinal inflammation elevated from a high - calorie diet and stem cell proliferation, which are linked to both colitis and colon cancer.

Further research could test these cancer stem cell gene expression at the RNA and protein level in circulating tumor cells and biopsies from patients on trial.

The team worked on tissue from three patients with colorectal cancer, taking normal bowel stem cells and cells from four different areas of the tumours.

President Barack Obama's 2017 budget request for science research and development includes funding for a cybersecurity initiative, a «Moonshot» to improve cancer detection and cures, research on low - carbon energy sources and improved STEM education.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeared.

Rather than approach the disease based on what region of the body it stemmed from, scientists began to identify cancers in terms of their genetic signatures.

«The focus of chemotherapy and existing standard - of - care is on killing cancer cells but instead we took a completely different approach which changes the environment the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the cancer cells but instead we took a completely different approach which changes the environment the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the Cancer Research Institute, who led the group that performed the study.

Comparing the markers on these stem cells with those on the surfaces of cancer cells, Johnson adds, will also help scientists determine if stem cells contribute to prostate malignancies.

What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.

The breakthrough, published online today and featured on the cover of the journal Cell Reports, was led by Mick Bhatia, director of the McMaster Stem Cell and Cancer Research Institute.

Stanford stem cell biologist and Forty Seven Inc. founder Irving Weissman, whose group pioneered research on CD47 in cancer, is a co-author on the new paper.

New research from scientists at Huntsman Cancer Institute (HCI) at the University of Utah and collaborators at University of Utah Health (U of U Health) sheds light on the complex process that occurs in the development of human sperm stem cells.

If dealing with the public relations nightmare over its on - off - on funding of Planned Parenthood wasn't enough, the Susan G. Komen for the Cure cancer charity last week also got entangled, somewhat bizarrely, in the debate over human embryonic stem (ES) cell research.

University of Michigan, Ann Arbor, stem cell researcher Sean Morrison, an outspoken proponent of allowing research on human embryonic stem cells (hESCs) in the state, has been wooed to Texas by its $ 3 billion state cancer research program.

A year earlier, after some sleuthing on ClinicalTrials.gov, the government site that keeps tabs on experimental cancer treatments, Nicole had stumbled on an article about an alternative source of stem cells: umbilical cord blood.

In the study, published online on February 4 in the journal Cell Stem Cell, Duke biomedical engineers show how colon cancer development is intricately linked to a specific microRNA that dictates how cells divide.

In the study, Shen's group focused on a microRNA called miR - 34a that gives cancer stem cells the odd ability to divide asymmetrically.

McKay and Tsai conclude that nucleostemin is involved in regulating the proliferation of both stem cells and at least some types of cancer cells, they reported at a meeting here on 20 November and in the December issue of Genes & Development.

Cancer cells resemble stem cells not because they can turn into other cell types, but because in developmental terms, they seem to go in the opposite direction: they begin to run through multiple layers of stop signs and barricades and just keep on multiplying.

With so much work needed in studying the nature of stem cells and using them to study disease processes, therapies based on ES cells seem very far down the line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.