Sentences with phrase «on cell adhesion»

Taken together, these results strongly suggest that the LPA2 signaling modulates T cell motility in the confined environments at least partly in an integrin - independent manner and may also act on cell adhesion to prevent over-adhesion to the substrates.

«Nanostructured materials are ideally suited to study the impact that spatial properties at the single molecule level have on cell adhesion.»

Not exact matches

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

A vaccine under development prevents adhesion proteins at the tips of spaghettilike pili on UTI - causing bacteria (left) from latching onto host cells.

As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).

When DIXDC1 is «turned on,» half a dozen or so focal adhesions grow large and sticky, anchoring cells to their spot.

More of the antibodies that coat the nanorod can therefore bind receptors on the surface of endothelial cells, and that leads to more effective cell adhesion and more effective drug delivery.

The neural cell adhesion molecule, N - CAM, appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

This physical change causes adhesion receptors on the cell surface called integrins to clump together.

We capitalized on one of the innate responses of microvascular endothelial cells, i.e., the up - regulation of cell adhesion molecules in response to inflammatory agents, to generate endothelial cell lines from different organs.

Established cell lines exhibited several inherent endothelial properties, including the expression of constitutive and inducible levels of endothelial cell adhesion molecules E-selectin, intercellular adhesion molecule - 1, and vascular cell adhesion molecule - 1, internalization of acetylated low - density lipoprotein, and formation of loop structures on Matrigel surfaces.

This work outlines how a receptor termed LFA - 1 on the surface of T - cells mediates adhesion to other cells such as cancer cells.

Using spatial correlation functions to quantify the differences between emergent cell lineage segregation patterns, we find that strong adhesion often, but not always, maximizes the size of clonal cell clusters on flat surfaces.

Nectin - 4 is a cell adhesion molecule that is expressed on a number of solid tumor cells.

Our laboratory focuses on the molecular basis of cell adhesion to collagen with a focus on the alpha2 beta1 integrin.

Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alphavbeta6 on porcine trophectoderm cells and integrin alphavbeta3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.

Multiple cell adhesion molecules shaping a complex nicotinic synapse on neurons.

Functional expression of CXCR4 (CD184) on small - cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

Adhesion, migration and mechanics of human adipose - tissue - derived stem cells on silk fibroin - chitosan matrix.

These chains are present on the cell surface and are crucial for many biological processes, including cell adhesion and signal transduction.

Almost all of these small neurons were identified to be cerebellar granule cells based on their morphology and that they were stained by anti-neural cell adhesion molecule L1 (Fig. 1A)[19].

Intercellular adhesion molecule - 1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.

Another interesting local network structure is centered around CLU, a gene shown to be involved in AD based on genome - wide association studies, with genes in the integrin family, involved in cell adhesion, clustered around CLU.

The origins of many of these and other genes specific to animal processes such as cell adhesion, and social control of cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».

Cell migration on 2D is initiated by protrusion of the cell membrane followed by formation of adhesions that link the actin cytoskeleton to the extracellular matrix (ECell migration on 2D is initiated by protrusion of the cell membrane followed by formation of adhesions that link the actin cytoskeleton to the extracellular matrix (Ecell membrane followed by formation of adhesions that link the actin cytoskeleton to the extracellular matrix (ECM).

Dr. Zutter focuses on the role of cell adhesion molecules in host - tumor interactions.

The Lauffenburger research group focuses on elucidating important aspects of receptor - mediated regulation of mammalian blood and tissue cell behavioral functions such as proliferation, adhesion, migration, differentiation, and death.

Usual suspects are adhesion molecules, gluing cells together, and the cytoskeleton, which can push and pull on these adhesion molecules.

Cells then move forwards by exerting traction forces on the adhesions at its front and by disassembling adhesions at the rear.

Shafaq - Zadah M, Gomes - Santos CS, Bardin S, Maiuri P, Maurin M, Iranzo J, Gautreau A, Lamaze C, Caswell P, Goud B, Johannes L (2016) Persistent cell migration and adhesion rely on retrograde transport of beta1 integrin.

Our final review article, from the labs of Maximilian Boesch (Kantonsspital St. Gallen, Switzerland) and Andreas Seeber (Medical University of Innsbruck, Austria), provides an update on the role of epithelial cell adhesion molecule (EpCAM) in cancer stem cells (CSCs) and the epithelial ‐ to ‐ mesenchymal transition (EMT) in colorectal cancer (CRC).

Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.

We examined the effect of loss of the gene on bacterial motility, adhesion and invasion of tissue culture cells and chicken colonisation, as well as the effect on the muropeptide profile of the peptidoglycan sacculus.

As described below, however, the LPA / LPA2 axis appears to affect T cell adhesion on the surfaces coated with LFA -1-ligand or fibronectin.

This research has centered on biomarkers of inflammation including interleukin - 6 (IL - 6), vascular cell adhesion molecule - 1 (VCAM - 1), and lymphocyte function - associated antigen - 1 (LFA - 1).

Fatty acids differentially influence phosphatidylinositol 3 - kinase signal transduction in endothelial cells: impact on adhesion and apoptosis.

Scientific studies have documented that the deadly powder on gloves increases wound infection, causes adhesions that can compress the bowels, and spreads tumor cells throughout the cavity.

Plc is a clinical stage biotechnology company, which focuses on the discovery, development and commercialization of novel antibodies for the potential treatment of diseases that involve protein misfolding or cell adhesion.

Programs with research emphasis on signal transduction in development and oncogenesis, cell adhesion molecules in development and oncogenesis, muscologskeletal atrophy and countermeasures, ovarian follicle development, neural regeneration, implantable therapeutic or diagnostic devices and application of computers in veterinary education.