Sentences with phrase «on cell cycle»

The effects of ellagic acid on cell cycle events and apoptosis were studied in cervical carcinoma (CaSki) cells.

Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001).

In search of a mechanism behind the finding that HIV / gp120 reduced proliferation of aNPCs, the scientists studied the effect of the protein on the cell cycle.

These experiments were essential to understanding the effect of gemcitabine on cell cycle and the effective scheduling of checkpoint inhibitor for maximal malignant cell kill.

In healthy human cells, the p53 protein helps prevent tumors by putting the brakes on the cell cycle to give an ailing cell time to fix itself — or die — rather than spawning more corrupted cells.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Scientists from the University of Wollongong have developed prototype battery cells based on sodium - ion technology, which the university says can achieve excellent cycling stability and easily be scaled up to mass production.

One new development in the 2010 election cycle was the first significant use of mobile advertising, particularly ads on the cell phone - optimized versions on websites and search engines.

I reached MacKay on his cell phone after this afternoon's endorsement press conference — the Indy Party's first official nod in this election cycle.

Nathaniel Hoyle of the MRC Laboratory of Molecular Biology in Cambridge, UK, and his colleagues have discovered that genes in a type of skin cell switch on and off during day - night cycles.

PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found.

She was on her way out to a pub after a scientific conference when she spotted Paul Nurse, who was working on cell - cycle regulation at Imperial Cancer Research Fund in London.

Two - way fuel cells Meanwhile, Versa, a solid oxide fuel cell stack supplier, is working with Boeing and «a large European company» on an innovative reversible SOFC that cycles back and forth between providing power and electrolyzing water into hydrogen and oxygen, Stokes says.

«Nematodes use the spit to transform the host cell into a nutrient sink from which they feed on during their entire life cycle.

This activation causes additional stress which keeps the macrophages «turned on» in a cycle that amplifies and further damages the cells and surrounding tissues.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

Firstly, salt stress causes a delay in cell division, leading to synchronization of cell cycles; secondly, survival probability depends on the individual bacterial cell's position in the cell cycle at the time of the second exposure.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Pérez de Castro, who are experts on protein AURKA and its role in the cell cycle.

Researchers at the University of Edinburgh and the MRC Laboratory for Molecular Biology in Cambridge used molecular analysis to find that concentrations of magnesium rose and fell in a 24 - hour cycle in all cell types, and that this impacts on the cells» internal clocks.

The researchers found that timing — specifically, the phase of the cell division cycle that bacteria were in when exposed to the antibiotic — had a significant effect on susceptibility.

This study, which will be published Oct. 24 in eLife, and two other new Northwestern studies in Oncotarget and Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

«Developing a vaccine that blocks the fusion of Plasmodium sex cells would be a huge step forward,» Snell said, noting that Plasmodium has a complex life cycle that depends on both mosquito and human hosts.

The predicted hosts for the Klosneuviruses are protists (single - celled eukaryotic (nucleus - containing) microorganisms) and while their direct impacts on protists are not yet worked out, these giant viruses are thought to have a large impact on these protists that help regulate the planet's biogeochemical cycles.

Nathaniel Hoyle of the Laboratory of Molecular Biology in Cambridge, UK, and his team have been investigating how the time of day affects wound healing, after they discovered that genes in a type of skin cell switch on and off during day - night cycles.

Yet in the past two to three years, biologists have discovered that daily cycles in the motility of the gut — the production of digestive enzymes, gene expression in gut cells and so on — rely on the activities of gut microbiota.

We created a thin - film device that operates on the same principle but with two types of solid redox materials that produce a change in the potential difference in the cell over a heating and cooling cycle,» firstauthor Takayuki?Shibata says.

Check a review on integrative view of cell cycle control in E. coli by L. Dewachter, an article on the return of cultures in microbiology by V. Marx, an article on microbial altruism and cheating in social amoebas by S. Noh.

Previous studies of beta cell proliferation generally have focused on mechanisms that kick off the cell cycle that leads to successful cell division.

Every cell in our bodies runs on a 24 - hour clock, tuned to the night - day, light - dark cycles that have ruled us since the dawn of humanity.

The study, commissioned by CHEOPS - a perovskite research project co-funded by the European research and innovation programme Horizon 2020, is being conducted by SmartGreenScans, a CHEOPS member, specialising in Life - Cycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by OxforCycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxforcycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxford PV.

The Effect of a DNA Damaging Agent on Embryonic Cell Cycles of the Cnidarian Hydractinia echinata.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

The Institute is currently running on a Site License by Flowjo, a flow cytometry data analysis software package which offers a range of analysis platforms that includes compensation, cell cycle, proliferation studies and kinetics.

Oxford, 04 April 2018 — Oxford PV — The Perovskite Company, the leader in the field of perovskite solar cells, today announced that its perovskite - on - silicon tandem solar cells, currently being used to conduct a life - cycle environmental impact study, have shown positive first results.

Hall and Rosbash then discovered a protein, named PER, that was made by the period gene, and figured out how it worked through a feedback mechanism — its own expression in the cell would cause PER to build up in the nucleus and would eventually effectively shut off the period gene, allowing it to cycle on and off on a daily schedule.

Panel D. mRNA expression analysis of urea cycle enzymes, as quantified by transcriptome analysis, was performed in enhanced hiPS - HEP cells from C12, C18, and C22 on Day 13 post-thawing (n = 2 batches per cell line) and compared to hphep cells on Day 1 post-thawing (n = 3 donors).

We are interested in the effect that high and low extremes of temperature have on various aspects of nematode biology, including: cell biology, cell cycle control, development and fitness.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

«Treatment for HIV currently relies on drugs which target the viruses cell - cycle to slow HIV replication (and the progression to AIDS)(called antiretroviral therapy (ART).

To study the effect of hypoxia / reoxygenation cycles on breast cancer, we exposed two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) to cycles of chronic hypoxia and nutrient deprivation.

Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.

This project — in collaboration with Texas A & M University — involves screening small molecules for specific effects on the yeast cell cycle that correlate with longevity.

In S. cerevisiae, approximately 900 genes out of 5800 are cell lethals, and an additional 900 act to stop cell cycle processes or cause impairment of growth on specific media (Burns et al., 1994).

Cyclin D1 production in cycling cells depends on ras in a cell - cycle - specific manner.

University of Tsukuba - based researchers developed a way to recover environmental heat with a new type of thin - film thermoelectric cell, based on two different materials that show changes in their redox potential on cycling of temperature.

2007 Selection of research article, «Duplication and segregation of the actin (MreB) cytoskeleton during the prokaryotic cell cycle,» published in Proceedings of National Academy of Sciences USA, by Faculty of 1000 Biology, which comprehensively and systematically highlights and reviews the most interesting papers published in the biological sciences, based on the recommendations of a faculty of well over 2,300 selected leading researchers.

The focus is on molecular microbiology and virology, and includes topics such as genomics, the gamut of plant and animal host - pathogen interactions, host immune responses, characterization and evolution of virulence determinants, cell cycle and differentiation, symbiosis in plant and animal associations, environmental microbiology, biodiversity and evolution, population dynamics, sex and mutagenesis, antibiotic resistance and production, drug and vaccine targets, as well as aspects of prion diseases and of fungal and protozoan biology.

However, we can not suspect any abnormal effect on parthenotes due to the aberrant expression of CCNA1 since the protein is not expressed at the blastocyst stage [33], and its cell cycle regulation role is limited in meiotic cells [34].

The large variability associated with the Timer mechanism is well known in the context of the cell cycle, and because of it, the Timer mechanism is not thought to be an appropriate way, on its own, to set stereotyped sizes (Amodeo & Skotheim, 2016).