The field's clinical cousins — pathology and hematology — also rely heavily
on cell shape.
Not exact matches
Wesley's emphasis
on the small group — most famously, his disciplined, close - knit «CLASS meetings» — has
shaped the landscape of modern American spirituality through «
cell groups,» Bible studies, and many other small - group modes of fellowship and worship.
In 1999, Anthony Atala grew a colony of bladder
cells, taken from a biopsy and seeded
on a «scaffold» in the
shape of a patient's own bladder.
Or me and this boy's mama will come after you with a sharp bento pick
shaped like a panda and feed you uncut grapes while you talk
on your
cell phone.
While you are making adjustments for your changing
shape, there are a lot of changes going
on inside your womb as your baby, who was just a cluster of
cells a couple of months ago, has organs, nerves, muscles and is looking more like a little person.
That development is important because a T
cell response will likely confer longer - term protection than current inoculations do and defend against a variety of flu strains (because T
cells would be
on the lookout for several different features of the flu virus whereas antibodies would be primarily focused
on the
shape of a specific strain).
Biologist Ann Cornell - Bell of Viatech Imaging in Ivoryton, Connecticut, put
on display star -
shaped cells, called astrocytes, from the rat hippocampus, a brain region associated with long - term memory.
For instance, to make a rod with collagen fibers aligned along its length (like a tendon) they cultured chondrocyte
cells in a dog bone -
shaped mold with loops
on either end.
So far the blocks have been used to build a variety of living 3D
shapes that have never before been created
on a
cell - by -
cell basis, such as tubes and solid spheres.
«Once we have proof that we can grow
cells in specific three - dimensional
shapes on or inside silicon, then we hope to come back to the tissue.»
The absorbance and scattering of light is determined by the size,
shape and material of the nanomaterial and, more importantly, it is also affected by any medium in close proximity to the nanomushroom, such as
cells that have been placed
on the slide.
Even abstract object
shapes could be differentiated based
on the observed
cell activity.»
Schematic illustration of
cells (blue mountain - like
shapes)
on top of nanoscale mushroom - like structures with silicone dioxide stems and gold caps, which have the potential to detect
cell proliferation in real - time.
In people with sickle
cell anemia, molecules of sickle hemoglobin clump together and form long rods that cause red blood
cells to become rigid and take
on a sickle
shape.
The mushroom -
shaped protein specializes in infecting
cells, first by binding a trio of sites
on its head to three separate sugar molecules
on the surface of targeted
cells.
The process, reported in Human Reproduction, utilizes DNA fingerprinting (an assessment of active genes in a given
cell) to boost the success rate of IVF and lower the chances of risky multiple births by identifying which of several five - day - old embryos are most likely to result in pregnancy The new method, which will replace unproved alternatives such as choosing embryos based
on their
shape, is likely to up the success of women becoming pregnant and lower their chances of having multiple births.
Lee is an expert
on the viral envelope, the dynamic outside surface of a virus that latches onto a
cell, then changes its
shape to let the virus enter and infect the
cell.
To determine if Sup35 could change
shape on its own or if it needed help from other molecules in the
cell, the team studied the purified protein in the test tube.
I was struck by the similarities between the pasta
shapes shown in Richard Webb's article
on their mathematical interpretation (15 October, p 48) and some shells of foraminifera, a type of single -
celled marine planktonic animal.
There it passes
on the fragments to other immune
cells, which produce a distinctive fork -
shaped antibody, known as immunoglobulin E, or IgE.
Because burgeoning teeth depend
on information from the budding embryonic jaw, work toward generating replacement teeth from dental stem
cells focuses
on growing them in the desired location in the recipient's mouth — but scientists are not yet sure the adult jaw can provide the necessary signals to
shape made - to - order teeth.
Depending
on which device they buy, researchers can photograph
cells at anywhere from 20x to 60x magnification, and use the included software to sort them by purely visual characteristics such as
shape and size, fluorescent markers, or both.
Those analyses have long relied
on qualitative changes in
cell shape to track physiological shifts.
Because of a quirk of evolution, these plant chemicals are close enough to the natural hormone's
shape to bind to the oestrogen receptors
on cells in the human body.
Since the development of the earliest clinical hematology analyzers, automated
cell counting based
on cellular
shapes has been a staple technique of medical and basic research laboratories.
In fact, tests undertaken
on red blood
cells showed that the star -
shaped polymer dosage rate would need to be increased by a factor of greater than 100 to become toxic.
To do this without a brain or nervous system, says Ken Showalter, a chemist at West Virginia University, the organism relies
on proteins and nutrients that «swish back and forth» through the
cell to communicate the location of the food and allow the organism to change
shape.
They chose this region because it has a large number of
cells and because the bird's feet hadn't been treated with arsenic, leaving the DNA there in better
shape than
on the rest of the preserved carcass.
The scientists zoomed in
on the ellipsoid body, a donut -
shaped structure in the middle of the fly's brain where they suspected the insect equivalent of head direction
cells might reside.
MERS CoV (CoV stands for coronavirus) has
on its surface an array of spike -
shaped proteins that bind to host
cells — specifically to receptor proteins called DPP4
on the surface of
cells that line human airways.
Other organs have been constructed from cultured
cells, but they were built
on a scaffolding to give them their three - dimensional
shape.
Most common among people of African descent, the disorder causes oxygen - carrying red blood
cells, which are normally flexible and round, to become rigid and take
on a crescent (or sickle)
shape.
To demonstrate the technique, the team printed a pattern of hydrogel with
cells in the
shape of a tree
on an elastomer layer.
This provides a wealth of information
on the patterns of
cell shape, motion and division.
To get a better grasp
on the problem, bioengineer Christopher Chen and colleagues at the Johns Hopkins University School of Medicine in Baltimore played with the
shape of growing stem
cells.
It is Neuroscience 101 that neurons pass
on electrochemical messages at communication sites called synapses, but it is less well appreciated that the vast majority of synapses are «tripartite,» consisting not just of a neuron sending a message and one receiving it, but also, nestled alongside each synapse, a star -
shaped glial
cell called an astrocyte.
As genetic circuitry
shapes up, scientists hope the new device will make it easier for them to program
cells to do things such as watch for disease, monitor pollution, or even turn
on medicine output.
«We saw that chem7 had hardly any effect
on the
shapes of the
cells and tissues, thus, suggesting that chem7 stops
cell division in plant
cells, but does not cause any severe damage to the
shapes,» describes Ueda.
In the new study, the researchers cultured mouse skin - cancer colonies
on various 2 - D and 3 - D environments of different
shapes and patterns to see if the tumor
shape contributes to activation of cancer stem
cells, and to see where in the tumor the stem
cells appeared.
Atala's method involved painting several coats of Kaitlyne's muscle
cells on the outer surface of a bladder -
shaped mold made of collagen.
The team focused
on one efflux pump protein, known as AcrA, which connects two other proteins in a tunnel
shape through the bacterial
cell envelope.
Here's the clue:
Cells in the center of the trophosome harbor small microbes with a classic rod
shape, but those
on the periphery house much plumper microbes.
Cells put a lot of effort into preventing proteins — which are like a string of beads arranged in a precise three - dimensional
shape — from unraveling, since a protein's activity as an enzyme or structural component depends
on being properly
shaped and folded.
The models showed that the rigid, crescent -
shaped red blood
cells that are the hallmark of sickle
cell disease don't cause these blockages
on their own.
On the surface of our numerous star -
shaped brain
cells called astrocytes, they have found the molecule LRP4 is important in ensuring healthy levels of a brain chemical that enables learning and memory, said Dr. Lin Mei, chairman of the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia at Augusta University and Georgia Research Alliance Eminent Scholar in Neuroscience.
The team used patterned photoactivation non-linear SIM to produce videos showing structural proteins break down and reassemble themselves as
cells move and change
shape, as well as the dynamics of tiny pits
on cell surfaces called caveolae.
«I'm interested in understanding how single
cells maintain their proper
shape,» said Athena Lin, graduate student at the University of California, San Francisco, and lead researcher
on the project.
«The
cells began to take
on the
shape of liver
cells, and even started to perform regular liver -
cell functions,» said UCSF Postdoctoral Scholar Milad Rezvani, MD, the paper's other lead author.
The research builds
on the team's previous work with a technique called three - dimensional culture, which involves incubating stem
cells in a floating ball -
shaped aggregate, unlike traditional
cell culture in which
cells grow in a flat layer
on the surface of a culture dish.
(Bottom) Plotting the characteristic ellipsoids for each
cell by how round they are in the two major cross sections reveals that
cells tend to different
shapes on different scaffolds — spheres at one extreme, long narrow rods at another.