Sentences with phrase «on cell signaling pathways»

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

Not exact matches

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Yale researchers identified a specific cell - signaling pathway that is dependent on DNMT3B.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

«There are signaling pathways that allow a cell to sense its environment and co-ordinate events to allow the cell to adapt to what's going on.

I found that culturing cardiac valve cells on synthetic hydrogels preserves their normal properties better than the traditional plastic plates do, and I discovered a signaling pathway connecting the stiffness of the supporting scaffold to the cells» cytoskeletal structure.

A signaling pathway is how developing cells get instruction on what types of cell to become, such as a liver cell, a skin cell, a brain cell, etc..

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

They focused on ItpkB because it is produced in HSCs, and the Sauer lab and others had previously shown that ItpkB controls a major signaling pathway in other cells that had been implicated in activating HSC.

Normally, when the body detects an outside invader such as a virus, a signalling system known as the PKA pathway responds by turning on 99 genes that then activate T - cells to destroy the invader.

Named after the BMP signal protein, this pathway controls the evolution of various cell types depending on the protein concentration, similar to the Wnt pathway, but in a different direction.

According to Prof. Holstein, the origin of the first nerve cells depends on the Wnt signal pathway, named for its signal protein, Wnt.

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

«There has been a lot of work on Wnt signaling pathways, for example, so there are a lot of small - molecule drugs that could be tested to trigger a stem cell to mature into a neuron.»

The Hedgehog signalling pathway is a good target for cancer researchers because it mainly switches back on in cancer cells and so blocking its function does not overly affect signalling in healthy cells.

Cell signaling pathways are a defined series of interactions between proteins that govern biological functions, initiated by receptors on the surface of cells.

Dr. Veenstra joined NCI - Frederick in the fall of 2001 to implement a state - of - the - art mass spectrometry center that focuses on the discovery of signaling pathways and networks that are activated within cells as a response to external perturbations.

«I believe that the result of this collaboration not only sheds light on the long sought mystery of arabinogalactan sugar chains but will also advance the understanding of the yet to be resolved signaling pathway between cells involving sugar chains.»

Effect of Saturated Stearic Acid on MAP Kinase and ER Stress Signaling Pathways during Apoptosis Induction in Human Pancreatic ß - Cells Is Inhibited by Unsaturated Oleic Acid.

Dr. Kulkarni's research focuses on investigating signaling pathways impacting growth and function of pancreatic islet cells with the long - term goal of improving therapeutic approaches for the treatment of type 1 and type 2 diabetes and obesity - associated conditions.

His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Multiple effects of a novel epothilone analog on cellular processes and signaling pathways regulated by Rac1 GTPase in the human breast cancer cells.

Cells rely on these pathways to respond appropriately to their environment (so that the right growth - controlling genes get turned on in response to a growth signal)-- but disruptions in signaling pathways can have dire consequences.

The gatekeeper (OLM - alpha2; red) counteract signaling coming from the TA pathway (blue), thereby allowing local inputs from the SC pathway (green) on the pyramidal cell (orange) to become stronger.

Tobias Heckel (Hoflack, TUD)-- «Revealing Src tyrosine kinase - dependent signaling pathways in osteoclasts: Implications on actin organization and cell polarity» (2008)

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

Although triple negative cancer cells lack the three critical genetic markers that are currently used to guide breast cancer treatment, the scientists» analysis suggests a strong reliance on signaling through pathways similar to those that affect fetal breast stem cell growth.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

To bypass the disruptive effects of the age - related accumulation of senescent cells, some investigators are working on possible ways to manipulate the signaling pathways involved in enforcing the senescent phenotype.

A Emory News item on a helpful part of the microbiome focuses on how the same type of bacteria â $ «lactobacilli â $ «activates the same ancient signaling pathway in intestinal cells in both insects and mammals. It continues a line of research from Rheinallt Jones and Andrew Neish on how beneficial bacteria stimulate wound healing by activating ROS (reactive oxygen species).

In 2014, Anna earned her Ph.D. in Cell & Molecular Biology at Drexel University where she focused on characterizing Sonic Hedgehog signaling pathway and its role in Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary cilia.

We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Elevated levels of the transcriptional regulators TAZ / YAP, key effectors of Hippo pathway signalling, mediate breast cancer cell growth dependence on exogenous glutamine.

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

The notion that a Nanog positive, ICM - like population of high probability self - renewing cells is a developmental ground state is supported by the expansion of this state in the presence of a blockade on the major signalling pathways known to promote ES cell differentiation, the MAP kinase / ERK cascade and GSK3β [42], [50].

Schematic illustration of signaling pathways on IFNα - or ATRA - induced RIG - G expression in NB4 cells.

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

Components of the major metazoan developmental signalling pathways, as well as classes of developmental transcription factors, are mostly present in Amphimedon and absent from Monosiga and other non-metazoan genomes13, 14,16,27,29, suggesting that ontogenetic development, including primary germ cell formation (Supplementary Note 8.4), originated on the metazoan stem3, 11,12.

Josin researchers made two major findings: They identified the mechanisms by which GLP - 1 can induce protective actions on the glomerular (renal) endothelial cells by inhibiting the signaling pathway of Ang II and its pro-inflammatory effect; and demonstrated a dual signaling mechanism by which hyperglycemia, via PKCβ activation, can increase Ang II action and inhibit GLP - 1's protective effects by reducing the expression of GLP - 1 receptors in the glomerular endothelial cells.

More recent work in our laboratory focuses on elucidating signaling pathways that mediate the activities of Eph receptors in cancer cells.

To explore if Hedgehog signaling also has an effect on diet - induced obesity after birth, Long and his team genetically engineered mice so that the Hedgehog pathway in fat cells would activate when they ate a high - fat diet.

The Buck's Kennedy is conducting research on cell - signaling pathways, in particular the mTOR pathway, which senses cellular nutrients, oxygen and energy levels and tells cells whether to grow, divide or stop.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

To examine the action of individual pathways in toto during ES cell differentiation, the FunGenES database was given an additional feature called «Pathway Animations» that depict dynamic changes in specific genetic, signaling or metabolic pathways viewed in time - related animations based on the KEGG annotation [44], [56].

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

«Here, we show how a common growth signaling pathway in cells can destroy one of the brakes on cell division to allow cell division to move forward,» Emanuele said.