Sentences with phrase «on cell survival»

This effect on cell survival was not endothelial cell - specific, since IC50 values for kahweol treatment of several human tumoral cell lines were similar to those obtained for HUVEC (results not shown).

Zinc finger nuclease mediated knockout of ADP - dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.

GLP - 1 receptors are also found in the brain, and prior research has shown that activating them can boost the function of dopamine connections, act as an anti-inflammatory, improve energy production, and switch on cell survival signals.

Not exact matches

Boldrini says that future research on the aging brain will continue to explore how neural cell proliferation, maturation, and survival are regulated by hormones, transcription factors, and other inter-cellular pathways.

Cancers associated with Kaposi virus infection have an Achilles heel: their cells» viability is directly dependent on the survival of the virus, which means that if the virus were to be eliminated cancer cells would no longer proliferate, hence the cancer would be cured.

The receptor is often expressed on epithelial cells, the type of cells that turn cancerous, and it promotes cell survival.

The idea to specifically study this group of patients was based on groundbreaking research Garon published in the New England Journal of Medicine last year, which found that among patients who received pembrolizumab, those with PD - L1 expression on at least 50 percent of their cancer cells showed the longest survival and disease control.

The researchers then found that, while the drug continued to inhibit FGFR activity in the resistant cells, its inhibition of FGFR signaling had no appreciable effect on the cells» survival.

The creations had stored well at refrigerated temperatures and circulated in the body with survival time on par with that of original red cells.

This mutation is on a particular receptor, or docking site, on the cancer cells that is crucial to the cell's growth and survival.

The investigators utilized a targeting method called RNA interference (RNAi) which, when delivered via these natural nanoparticles or exosomes, zero in on mutant KRAS in pancreas cancer cells, impacting tumor burden and survival in multiple pancreas cancer models.

PARP inhibitors target and block proteins which cancer cells depend on to repair DNA for their survival.

Versions of ZMYND11 that could not bind to the trimethyl group on H3.3 did not suppress cancer cell growth or survival.

When BRCA1 is mutated, ANG1 switches on, new blood vessels are formed, and cancer cells get the nutrients critical to their survival.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

Combining their strategy with an existing immunotherapy treatment that works by releasing the «brakes» on immune cells, they found they could shrink melanoma tumors, and prolong survival in preclinical models for melanoma.

Inglis attributes this success to the fact that the bacteriocin targets a receptor on the bacteria's cell surface that is essential to its survival.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

Firstly, salt stress causes a delay in cell division, leading to synchronization of cell cycles; secondly, survival probability depends on the individual bacterial cell's position in the cell cycle at the time of the second exposure.

«The research showed that the aggressive form of basal breast cancer cells may be dependent on PLK4 for survival and that depleting it induced cell death,» says Dr. Mak.

But in individual cells this effect is short - lived: after just 30 minutes, the survival rate no longer depends on the exposure history.

The Italian researcher faced prejudice and adversity as a woman and as a Jew, but went on to elucidate a growth factor essential to the survival of nerve cells

«We're finding that leader and follower cells have a symbiotic relationship and depend on each for survival and invasion,» he says.

The cells» survival relies on a delicate balance between energy and reactive oxygen species (ROS) production.

Professor Ahmed and his team have identified how cancer cells rely on a process called NMD for their survival.

«It appears that one or more of these proteins, either within the bacterial cell envelope or on its surface, are essential to its growth and survival.

He managed to switch on a survival mode in bone cells by inactivating the oxygen sensor PHD2 before implantation.

Matthew Paszek, assistant professor of chemical and biomolecular engineering at Cornell and Valerie Weaver, at the University of California, San Francisco, led the study on glycoprotein - induced cancer cell survival, published online in Nature.

A new study by a Cornell University researcher found this coating is especially thick and pronounced on cancer cells and is a crucial determinant of the cell's survival.

«This shows that the antibody not only can exert pressure on the virus, but also can shorten the survival of infected cells,» says first author Ching - Lan Lu, a visiting student in Dr. Nussenzweig's lab.

Once the elongating fibers have established the appropriate synaptic contacts with the target cells, the continued survival of the innervating cells in the ganglion appears to depend on the availability of NGF.

The strategy of giving a higher proportion of plasma is based on the belief that maintaining the balance of coagulation factors carried in plasma would reduce the overall amount of bleeding, requiring lower amounts of red blood cells and improving survival.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

Matthew Paszek, assistant professor of chemical and biomolecular engineering, led the study on glycoprotein - induced cancer cell survival, published online in Nature June 25.

Because cancer cells acquire mutations in oncogenes — genes that can transform cells into cancer cells — to support their growth and survival, a great deal of research has focused on identifying oncogenes that could be targeted by cancer drugs.

Highly dependent on their estrogen receptors for growth and survival, these tumor cells are sensitive to hormonal therapies, making drugs like tamoxifen and fulvestrant effective first - line therapies for many patients.

Thus, CXCR4 disruption had no impact on cell viability, but conferred a significant survival advantage in the presence of HIV strains that can use CXCR4 to infect cells.

According to Whitehead Institute researchers, protein production or translation is tightly coupled to a highly conserved stress response — the heat shock response and its primary regulator, heat shock factor 1 (HSF1)-- that cancer cells rely on for survival and proliferation.

That is why loss of autophagy in regulatory T cells produces a two-fold effect on both survival and stability.»

Exon - Based Transcriptome Profiling Reveals Genes That Have Prognostic Impact on the Survival of Young High Risk Diffuse Large B - Cell / Follicular Grade 3 Lymphoma Patients Treated with Dose - Dense Chemoimmuno - therapy and CNS Prophylaxis.

A national study on conditional survival, excess mortality and second cancer after high dose therapy with autologous stem cell transplantation for non-Hodgkin lymphoma.

CAMBRIDGE, Mass. — Protein production or translation is tightly coupled to a highly conserved stress response that cancer cells rely on for survival and proliferation, according to Whitehead Institute researchers.

Thus, treatment with X4 - ZFNs of both wild - type and ccr5Δ32 CD4 + T cells confers stable cxcr4 disruption and a marked survival advantage in the presence of R5X4 - HIV and X4 - HIV in vitro without any detectable effect on cell growth or viability in the absence of HIV.

Thus, the survival of XpdTTD / † XPCS (and XpdTTD / † XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2).

The influence of the src - family kinases, Lck and Fyn, on T cell differentiation, survival and activation.

Dr. Tu's research focuses on the metabolic state of cells and responses to conditions that induce or halt cell division to promote survival and homeostasis.

Thus, the improved UV survival observed in compound heterozygote cells (Figure 4A) and likely the rescue of TTD progeroid symptoms (Figure 3) were not due to normalisation of TFIIH levels, suggesting a qualitative rather than a quantitative effect on these phenotypes in vivo.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

They found out that pre-organ transplant infusion of MSC in 1 or 2 doses [on day - 7 and day - 1] induced a profound T cell hyporesponsiveness and prolonged B6C3 cardiac allograft survival.