Sentences with phrase «on cells in the immune system»

Dendritic cell vaccines — focus on cells in the immune system that recognize cancerous cells.

Not exact matches

The medicines, which help unleash the immune system on cancer cells, were tested in patients with advanced lung cancer.

Hoping to learn something about how the human body defends itself against cancer, he had zeroed in on a complex regiment of lymphocytes called T cells, common to the immune systems in both mouse and man.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Moreover, in the aftermath of surgery, the immune system concentrates most of its efforts on healing the surgical wound, lowering its guard against cancer cells.

As might be expected of an autoimmune disease, where the immune system turns on healthy tissue, all the genes play a role in controlling the growth and multiplication of cells in the immune system.

«Current therapies in clinical trials are focused on targeting genetic changes in tumors and helping to boost one's immune system to fight the cancer cells.

The Cologne molecular biologist is an expert on root - colonizing fungi and the plant immune system, the Würzburg chemist is a specialist for sugar molecules and their functions in cells and organisms.

Dendritic cells are intelligence - gathering immune cells, gathering information on viruses, bacteria, cancer and fungi to aid the immune system in fighting disease.

In effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumorIn effect, PD - 1 may actually help to preserve a «reserve force» of T cells that can fight on later in the long - term cellular war between the immune system and foreign invaders or tumorin the long - term cellular war between the immune system and foreign invaders or tumors.

The protein puts the immune system's brakes on, keeping its T cells from recognizing and attacking cancer cells, said Dr. Antoni Ribas, the study's principal investigator and a professor of medicine in the division of hematology - oncology at the David Geffen School of Medicine at UCLA.

«Suppressing a progenitor from creating the subtype of dendritic cells implicated in causing lupus, for example, could be an efficient way of treating autoimmune diseases while minimising the impact on the rest of the immune system.

The researchers found that production of this mucus lining depends upon a single immune system regulator — the NLRP6 inflammasome — that controls mucus secretion by cells in the wall of the intestine, just like turning on a faucet.

«We hypothesized that individual mutations in viral genes could be expected to have a range of effects on the virus's ability to replicate, to infect new cells and escape the immune system,» Carlson says.

In this study, the SIgN team discovered for the first time that the integrity of p53 affects the production of a special cell surface protein called Major Histocompatibility Complex (MHC) class I. MHC class I molecules on the cancer cell surface serve as targets for the immune system.

George Klinman, an FDA immunologist and lead author of the report, speculates that dangling the protein in front of the immune system in an unusual setting — on a muscle cell — might be what triggers the inappropriate response.

In a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assaulIn a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assaulin the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assault.

Together, the two studies advance the idea that gut microbes play a role in turning the immune system against nerve cells, causing MS.. It will take a lot more work to develop cures or preventive strategies based on that, but the research raises the intriguing possibility of treating an often - devastating disease with something as low - tech as fecal transplants or probiotics.

One advantage of this method is that it only activates a certain type of immune cell, the dendritic cell or T - cell, and only in one part of the body, near the draining lymph nodes or tumor, which helps cut down on the system - wide side effects often seen with chemotherapy.

Allison's seminal work focuses on a protein called CTLA - 4, which reins in T - cell activation in the immune system.

The disease commonly starts in childhood and causes the body's own immune system to attack and destroy the insulin - producing cells in the pancreas, leaving the patient dependent on life - long insulin injections.

In particular, it has evolved to show itself three to nine months after infection, allowing its own destruction by displaying antigens on its cell surfaces so the dog's immune system can destroy it.

Interferons are molecules produced by cells in response to viral or bacterial infection, and which act on neighboring cells to prevent the spread of the infection, shut down protein synthesis, and activate the immune system.

Most importantly, the doxorubicin - decorated diamonds had no effect on white blood cell count, an indicator of immune system activation that's often the deciding factor in whether a patient can continue chemotherapy.

Previous studies have found evidence that IL - 27 has a moderating effect on the Th2 response, and in general, keeps T - cells — the «battle tanks» of the immune system — from causing too much damage.

Prof. Mandelboim and his research collaborators found that the NKp46 receptor present on Natural Killer or NK cells (an essential part of the immune system) play a critical role in the development of the disease in mice.

New technologies are coming to the fore that allow interrogation of the types of cells interacting with tumors, in particular providing intelligence on the broad variety of complex associations between tumor cells and the immune system.

In a report on their experiments, published April 2017 in the Proceedings of The National Academy of Sciences, the researchers say they found evidence that microglia, a cell type found in most vertebrae innate immune systems, affect the Müller glia's regenerative response and can be harnessed to accelerate the growth of new tissue in the retinIn a report on their experiments, published April 2017 in the Proceedings of The National Academy of Sciences, the researchers say they found evidence that microglia, a cell type found in most vertebrae innate immune systems, affect the Müller glia's regenerative response and can be harnessed to accelerate the growth of new tissue in the retinin the Proceedings of The National Academy of Sciences, the researchers say they found evidence that microglia, a cell type found in most vertebrae innate immune systems, affect the Müller glia's regenerative response and can be harnessed to accelerate the growth of new tissue in the retinin most vertebrae innate immune systems, affect the Müller glia's regenerative response and can be harnessed to accelerate the growth of new tissue in the retinin the retina.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

In 2010, it was discovered that enhancers directed expression of RNA on a broad scale in neurons and macrophages, a type of immune system celIn 2010, it was discovered that enhancers directed expression of RNA on a broad scale in neurons and macrophages, a type of immune system celin neurons and macrophages, a type of immune system cell.

This summer, a slew of new studies reported results on efforts to shift the balance of cells in the immune system in hopes of keeping disease at bay.

In the current study, the researchers showed that FGPs are present on the surface of the zebrafish brain and that these blood vessel - associated FGPs do not arise from the immune system, as had been previously thought, but from endothelial cells themselves.

Patients in the study were treated with immune checkpoint inhibitors that block the activation of PD1, a protein on immune system T cells that halts immune response.

On the contrary, short - chain fatty acids, first and foremost propionic acid (or its salt propionate), lead to the development and propagation of regulatory cells of the immune system in the intestinal wall.

In a new study published in Science Advances, a group of University of Wisconsin - Madison researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency, to shine a spotlight on the virus so the immune system knows to fighIn a new study published in Science Advances, a group of University of Wisconsin - Madison researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency, to shine a spotlight on the virus so the immune system knows to fighin Science Advances, a group of University of Wisconsin - Madison researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency, to shine a spotlight on the virus so the immune system knows to fighin the human body have an armament designed to prevent HCMV from achieving and maintaining this latency, to shine a spotlight on the virus so the immune system knows to fight.

On the contrary, short - chain fatty acids promote the development and propagation of regulatory cells in the immune system.

TIM - 3 is known to play a critical role in regulating the immune system, suggesting that it may be possible to target TIM - 3 on dendritic cells in order to activate T cells.

A study of the way malaria parasites behave when they live in human red blood cells has revealed that they can rapidly change the proteins on the surface of their host cells during the course of a single infection in order to hide from the immune system.

While animals have a wide variety of immune cells and in some cases an interconnected immune system plants must rely on other methods to fight infection.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

The infection rapidly turned on a wide range of genes involved in immune system activation and cell death, they conclude, bolstering the hypothesis that the greatest harm may not have been done by the virus itself, but by an over-reactive immune system.

The ccr5 receptor, a protein found on the surface of cd4 T - cell lymphocytes in the immune system (try saying that quickly), may hold the key to ending the aids pandemic (see «The End of AIDS»).

pTreg cells were also believed to exist in the small intestine to inform the immune system on which food antigens can enter our body.

Walford's new research is based on the fact that in mice and humans, the immune system malfunctions during aging, losing the ability to distinguish between healthy cells and invasive pathogens such as bacteria and viruses.

The other end, known as the constant region, binds to receptors on the surface of cells that can direct the immune system to respond in a variety of ways, all in the hopes of eliminating the target on the variable end of the antibody.

Key elements of the immune system, they also have the ability to turn into several cell types after having passed the endothelial barrier, in order to fulfil different functions depending on the tissue.

In T1D, beta cells are mistakenly attacked by the body's own immune system, and much prior research has focused on ways to prevent this autoimmune response.

In a lupus patient, this could cause the immune system to ramp up its attacks on the body's cells.

And on page 1693, another team reports further evidence of the action of natural selection in people: A gene expressed in microglia, immune cells of the nervous system, produces a protein found only in humans.

ES cells from a 129 mouse, on the other hand, were unable to form teratomas in B6 mice because the animals» immune systems attacked the cells, which they recognized as foreign.