Sentences with phrase «on cells in the laboratory»

Before any tests or trials take place on patients, millions of chemical compounds are tested on cells in the laboratory, in a bid to detect adverse effects.

Not exact matches

To create the effect of tobacco smoke on cells, Vaz, Baylin and their colleagues began their studies with human bronchial cells, which line the airways of the lungs, and grew them in a laboratory.

Nathaniel Hoyle of the MRC Laboratory of Molecular Biology in Cambridge, UK, and his colleagues have discovered that genes in a type of skin cell switch on and off during day - night cycles.

While other papers have examined these mutations using expensive and time - consuming experiments on live ferrets and laboratory cell cultures, Deem and Melia Bonomo used the pEpitope method to rapidly calculate how much the egg - passage mutations would decrease vaccine efficacy in humans.

The German - born Frank, who was inducted as a AAAS fellow in 1997, is a professor of biochemistry, molecular biophysics and biological sciences at Columbia in New York City and the Scottish - born Henderson, who has been a AAAS member since 1996, has served as director of the MRC Laboratory of Molecular Biology research facility where hundreds of scientists work on neurobiology, cell biology and biotechnology.

We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer of the University of California, San Diego, on the new paper, which was published in Cell Stem Cell in April 2017.

«The siRNA delivery targeted carriers constructed today hone in on specific cells and require chemical conjugation of the targeting agent,» says Prof. Dan Peer of the Laboratory of Precision Nanomedicine at TAU's School of Molecular Cell Biology and Biotechnology, who led the research.

Focusing on energy - transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically - approved drug stiripentol, 3 natural products — caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid — and experimental pharmaceuticals, such as actinonin, FK866 and 2 - DG.

The Systems Biology Group at the Pacific Northwest National Laboratory in Richland, Washington, employs 90 - plus staff scientists working on proteomics, microbial - cell dynamics, cell and molecular imaging and spectroscopy, computational biology, and bioinformatics.

Protein chemist Michael Way, cell biologist Sally Cudmore, and their colleagues at the European Molecular Biology Laboratory in Heidelberg and at the Pasteur Institute in Paris have found that vaccinia — a virus used in smallpox vaccines — surfs through cells on piles of actin, one of the basic structural proteins in the cellular skeleton.

Building on the newly - published pilot study, the team will conduct experiments using a windtunnel which measures the behaviour of mosquitoes towards odours and electrodes which track the response of individual odour - detecting cells from within the antenna of the mosquito in specially - designed secure laboratories at the School to measure the responses of malaria - infected Anopheles gambiae s.s. females to human odours.

In the case of SISSA's Neurobiology Laboratory, the focus was on the genes of olfactory receptors which, surprisingly, are also present in the cells that synthesise dopamine and that die in Parkinson's diseasIn the case of SISSA's Neurobiology Laboratory, the focus was on the genes of olfactory receptors which, surprisingly, are also present in the cells that synthesise dopamine and that die in Parkinson's diseasin the cells that synthesise dopamine and that die in Parkinson's diseasin Parkinson's disease.

«Despite the fact that the literature describes only correlation between verbal memory tests and hippocampal cell densities in patients with left hippocampal sclerosis, we found a correlation between right hippocampal cell densities and performance on visual memory tests, including both immediate and delayed recall,» says authors Sandra Mara Comper and Anaclara Prada Jardim, students in the laboratory of Dr. Elza Marcia Yacubian at the Federal University of São Paulo.

Barnes's team went on to show last year that soya extracts could also inhibit the growth of prostate cancer cells in laboratory tissue cultures.

Schiffman and his team conducted another series of experiments in the laboratory on blood samples from adult African elephants to find how these genes respond to DNA damage in the elephant cells.

After completing her graduate studies in 2006, she joined the laboratory of Dr. Craig B. Thompson at the University of Pennsylvania for postdoctoral work focusing on cancer cell metabolism.

By now, European astronauts had hoped to be established in their space laboratory called Columbus, where they would be melting and solidifying conductive metals, studying microgravity effects on single - celled organisms, investigating human balance disorders, and carrying out dozens of other experiments.

One of these, UJ3, is as effective as the industry - standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer and melanoma.

The treatment did a lot to prevent cell migration, a key mechanism in metastasis, in experiments on laboratory cultures (in vitro) of cancerous human cells.

«These findings build on a long history of work in our laboratory investigating mechanisms by which cancer cells respond to environmental stresses,» says Grant.

In particular, his laboratory focuses on the regulation of key signaling networks that regulate cancer cell growth and survival.

«This lets us keep age - related signatures in the cells so that we can more easily study the effects of aging on the brain,» says Rusty Gage, a professor in the Salk Institute's Laboratory of Genetics and senior author of the paper, published October 8, 2015 in Cell Stem Cell.

Greider, a young new investigator at Cold Spring Harbor Laboratory (CSHL) on Long Island, New York, and her collaborator, molecular biologist Calvin Harley of McMaster University in Hamilton, Ontario, had shown 2 years earlier that telomeres shorten with each cell division.

All cancer research relies on a steady supply of cells — both normal and cancerous — that can be grown in the laboratory.

Researchers at the U.S. Department of Energy's (DoE) National Renewable Energy Laboratory have succeeded in producing CIGS cells that can convert nearly 20 percent of the sunlight that falls on them into electricity.

A red solution of a patient's cells is placed on a biodegradable bladder mold in a Wake Forest University laboratory.

For example, cell culture or biological analysis, which are conducted in biology laboratories, can be performed on a microfluidic chip.

In experiments on dog cancer cells in the laboratory it was found that the newly developed antibodies did, in fact, bind to canine cancer cells with greater specificitIn experiments on dog cancer cells in the laboratory it was found that the newly developed antibodies did, in fact, bind to canine cancer cells with greater specificitin the laboratory it was found that the newly developed antibodies did, in fact, bind to canine cancer cells with greater specificitin fact, bind to canine cancer cells with greater specificity.

Cell - based biosensors can simulate the effect of various substances, such as drugs, on the human body in the laboratory.

Previous studies have subjected phytoplankton to oil in laboratories to test their sensitivity and found differences in the impact on oceanic vs. coastal phytoplankton and differences when phytoplankton were in nutrient - rich or nutrient - poor water, as well as damage to some phytoplankton cells at various concentrations of oil.

Professor Wolf Reik, Head of the Epigenetics Laboratory at the Babraham Institute and co-lead scientist on this research, said: «Transcription in individual cells can vary between cell types but also between cells of the same type.

The current study was based on previous studies in the laboratory of Nita Ahuja, M.D., director of the Sarcoma and Peritoneal Surface Malignancy Program and professor of surgery at the Johns Hopkins University School of Medicine, which showed that guadecitabine limited the growth of colorectal cancer cell lines when combined with irinotecan, says Azad.

On laboratory dishes, these stem cells were found to be havens for viral reproduction, resulting in cell death and / or disruption of cell growth.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

Ngai, who directs the Functional Genomics Laboratory in UC Berkeley's California Institute for Quantitative Biosciences, focuses on the cells and regulatory molecules involved in our sense of smell.

By tweaking the locations and identities of motor neurons, and then watching the resulting patterns of activation using their new fluorescent technique, Chris Hinckley in the Pfaff laboratory found that the CPG didn't rely solely on the cells» locations to connect to them.

Researchers at the University of Edinburgh and the MRC Laboratory for Molecular Biology in Cambridge used molecular analysis to find that concentrations of magnesium rose and fell in a 24 - hour cycle in all cell types, and that this impacts on the cells» internal clocks.

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

Preliminary safety testing on cells grown in the laboratory showed the drugs were not toxic to mammalian cells because they only inhibit the bacterial ribosomes and not mammalian ribosomes.

The FACC - 29 library depends on microsatellite «signatures» that can be used to identify short segments of a cell's genetic sequence, in this case developed by the laboratory of study co-author, Dawn L. Duval, PhD, also working at the FACC.

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 200In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 200in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 200in Singapore, obtaining my PhD in 200in 2000.

Our investigations on human cell lines in the laboratory have shown that synthetic cannabinoids, in the high concentrations found in cells in the oral cavity or in the lungs, for example, are likely to trigger damage to the DNA that may have significant consequences for the consumers of such substances.

«What we've shown is that we can take these cells out of a mouse and study them and regulate them in the laboratory by providing them with a specific factor,» says Peter C. Gray, a staff scientist in Salk's Clayton Foundation Laboratories for Peptide Biology, who collaborated on the new work with Benjamin T. Spike, a senior research associate in the laboratory of Salk Professor Geoffrey M. Wahl.

Lo's laboratory has for more than a dozen years studied immune responses in the gut and airways, focusing particularly on cells which function as an early warning in the immune system.

On 11 March, the European Molecular Biology Laboratory (EMBL) issued a press release proudly announcing that a research team there had deciphered much of the genetic sequence of one of the most widely used cell lines in cancer studies and had made the information available publicly.

Research in the Meissner laboratory focuses on how stem cells achieve and maintain pluripotency, and the role that epigenetic modifications play in this process.

«Our research shows that cells derived from corneal stem cells are attractive candidates for generating corneal cells in the laboratory,» said Alexander Ljubimov, PhD, director of the Eye Program at the Board of Governors Regenerative Medicine Institute and principal investigator on this research study.

Nathaniel Hoyle of the Laboratory of Molecular Biology in Cambridge, UK, and his team have been investigating how the time of day affects wound healing, after they discovered that genes in a type of skin cell switch on and off during day - night cycles.

«First, we must bear in mind that the study was done on human cancer cells cultured in the laboratory, since it would be unethical to do it in humans.

Carried out in cells in the laboratory, in mice and in samples from patients» tumours, the researchers showed this «safe haven» lets melanoma cells turn on a parallel set of cell signals that helps them survive.