Designed assays to evaluate novel drugs, with an emphasis
on cellular pathways involving the enzymes poly - ADP - ribose polymerase, poly - ADP ribose glycohydrolase, cyclophilins and sirtuins.
However, more information is needed
on cellular pathways and targets affected by these inhibitors before pharmacological optimizations can be pursued.
Not exact matches
Intermittent fasting, regular exercise and consumption of dietary phytochemicals can have a major positive impact
on health by bolster - ing adaptive
cellular stress response
pathways that protect against and counteract a range of major diseases.
Once there, the protein acts
on the osteoblasts and inhibits Wnt activity, which is a
cellular signalling
pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.
The transcription of non-coding regions in the genome is precisely regulated by
cellular signaling
pathways — and
on a grand scale: up to 80 per cent of the RNA copies were non-coding.
A newly discovered stress response
pathway relies
on fat molecules to mediate
cellular health.»
To coordinate their size and growth with current environmental conditions, cells rely
on the mechanistic target of rapamycin complex 1 (mTORC1)
pathway, which senses
cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.
My lab is investigating the normal
cellular functions of signaling
pathways implicated in neurological disease, with an emphasis
on axon growth and guidance.
Hsieh brings expert knowledge of prostate cancer and the PI3K
pathway and its effects
on a critical
cellular process: translating genetic material into proteins, our cells» workhorses.
His lab went
on to molecularly decode a number of new components of this
cellular starvation
pathway, which connects nutrition and exercise to suppression of both cancer and diabetes.
Multiple effects of a novel epothilone analog
on cellular processes and signaling
pathways regulated by Rac1 GTPase in the human breast cancer cells.
We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4
on cell signaling
pathways and cytoskelatal structure and function at molecular,
cellular and behavioral levels.
The lab focuses
on clarifying the mechanisms of brain plasticity, gene expression, and responses of
cellular elements to different psychotropic drugs, and have identified several novel brain sites and
pathways that constitute attractive targets for new drug development.
Altieri and his team are currently focused
on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the
cellular stress response and how exploiting these
pathways may provide new cancer therapeutics.
This is why recent work in the field of cancer research has focused
on picking apart the complex
cellular pathways involved in the development of different cancers and identifying the roles of key proteins involved, with the goal of being able to discriminately and effectively eliminate cancerous cells from the body.
Using these orthogonal measures of
cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce significant
cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent
on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).
Vignali and his colleagues used a variety of molecular and
cellular techniques to show that Sema4a binding to Nrp1 turns
on a biochemical
pathway in mouse regulatory T cells that enhances their function, stability and survival.
Novel treatments for cancer depend
on the ability to modulate aberrant
cellular pathways and effectively deliver therapeutics to the tumor.
Studies
on the effects of GHRH antagonists
on prostate and lung cancers demonstrated their ability to modulate signaling
pathways involved in
cellular proliferation, survival, metastasis, and apoptosis.
The Buck's Kennedy is conducting research
on cell - signaling
pathways, in particular the mTOR
pathway, which senses
cellular nutrients, oxygen and energy levels and tells cells whether to grow, divide or stop.
Cathie (John Innes Centre and University of East Anglia, Norwich, UK) is well known for her earlier research
on cellular specialization in plants and
on the phenylpropanoid
pathway.
For example, the SCN detects light at dawn and through a complex
cellular genetic
pathway, turns off the melatonin that keeps us asleep, and turns
on cortisol to wake us up.
Similar to the physical and
cellular burn of exercise that creates some oxidizing free radicals, the «stress» from cruciferous vegetables stimulates our mitochondria to produce homemade antioxidants to counterbalance the oxidation and protect our vital DNA.28 Even cancer cells have caught
on to this central role of our mitochondria — the bastards can amplify their levels of some of these same
pathways — further stressing their importance for survival.25 However, our cells still seem to have the upper hand, as multiple studies show that the organosulfur chemicals in many of these anticancer vegetables can severely stress cancer cells, leading to oxidative damage, and ultimately, death.29