All previous work
on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat.
Tuesday, September 27 10:45 - 11:15 am — Kazutoshi Takahashi does a deep dive
on cellular reprogramming, uncovering the molecular mechanisms behind pluripotency.
«Eventually you have to replace those genes with small molecules, with proteins, with whatever,» says Ding, who is working
on cellular reprogramming methods that use small molecules, rather than viruses.
Not exact matches
Sheng Ding, PhD, a senior investigator in the Roddenberry Stem Cell Center at Gladstone and co-senior author
on the study, adds, «This new
cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods.
Yamanaka said, «We hope that further trials of iPSC - based therapies, accompanied by basic research focused
on gaining more detailed, molecular insights into the process of
cellular reprogramming itself, will result in unveiling the full potential of iPSCs in the next decade.
For example,
cellular reprogramming is an inefficient process because many of the target areas
on the genome are covered by other proteins, like a childproof cap
on a medicine bottle, which prevents the
reprogramming factors from binding there.
CellR4 publishes Editorials, Reviews, Original Papers, and Scientific Correspondence / Letters
on subjects regarding
cellular repair, replacement, regeneration and
reprogramming, from basic science to translational research and clinical trials.
3:30 - 4:00 pm — Deepak Srivastava discusses recent progress
on treating cardiovascular disease with
cellular reprogramming.
The timing of the
reprogramming and the factors required seem to vary depending
on cellular context [12]--[17].
He conducted some of the first studies
on direct
cellular reprogramming and successfully transformed scar tissue in the heart into healthy, beating heart muscle cells after a heart attack.