Sentences with phrase «on cellular response»

Not exact matches

Intermittent fasting, regular exercise and consumption of dietary phytochemicals can have a major positive impact on health by bolster - ing adaptive cellular stress response pathways that protect against and counteract a range of major diseases.

It was a gene called the von Hippel - Lindau (VHL) factor, which encodes a protein that puts a brake on the cellular hypoxia response.

There he worked on anticancer vaccines, identifying drug targets, preparing vaccine formulations, and testing cellular responses in vaccinated patients.

The next step in this line of investigation, already in development, is to learn how cellular responses vary, on a molecular level, among roots of flooded plants when the hormone is not present, which would make it possible to create a response model where this signaling path would play a key role.

Professor Fallon said: «This identification of an early stage cellular checkpoint that can act as a break on allergic responses has important implications for the development of new therapeutic approaches for asthma and other allergic diseases.»

A newly discovered stress response pathway relies on fat molecules to mediate cellular health.»

With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.

The team knew from previous experiments that ISRIB prevents the cellular stress response by stabilizing a protein called eIF2B, which typically helps turn on protein production.

«Following on the work of TSRI Professor Ardem Patapoutian, who has identified many of the genes that endow these neurons with selective responses to temperature, pain and pressure, we have found a way to produce induced sensory neurons from humans where these genes can be expressed in their «normal» cellular environment,» said Associate Professor Kristin K. Baldwin, an investigator in TSRI's Dorris Neuroscience Center.

Although the metabolic responses observed are consistent with the cellular consequences of osteocalcin exposure in pancreatic β - cells and myoblasts in vitro (27 — 29, 61), the metabolic effects of exercise and WBV may not be dependent on osteocalcin per se.

Now, Professor Martin and colleagues have discovered that in response to specific types of cell damage, Parkin can trigger the self - destruction of «injured» nerve cells by switching on a controlled process of «cellular suicide» called apoptosis.

On a cellular level, FnEDA triggered an immune response in skin cells, leading to fibrosis.

In the past 27 years, we have found that this cycling sugar modification of proteins — called O - linked N - acetylglucosamine, or O - GlcNAc — is nearly as common as protein phosphorylation and often competes with it at the same or proximal sites on proteins to regulate nearly every cellular process in response to nutrients and stress.

Research programs of Immunopathology Unit aim to dissect the cellular and molecular mechanisms responsible for immunopathological responses of the liver, with emphasis on the responses that occur during infection with hepatitis B virus (HBV).

We produce live and inactivated viruses in our BSL2 and BSL3 facilities, and perform immunogenicity and efficacy studies in pigs (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA - based motors using a combination of biochemical, biophysical and structural techniques.

On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

The lab focuses on clarifying the mechanisms of brain plasticity, gene expression, and responses of cellular elements to different psychotropic drugs, and have identified several novel brain sites and pathways that constitute attractive targets for new drug development.

On the other hand, histidine kinases allow bacteria, plants, and fungi to sense and respond to their environment, regulating a number of cellular responses such as osmoregulation, chemotaxis, sporulation and microbial pathogenesis (37).

The Kaufman lab is focused on understanding the fundamental mechanisms that regulate protein folding and the cellular responses to the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER).

Altieri and his team are currently focused on three programs to understand the biology of survivin with respect to cell cycle progression, in particular, mitosis, cell survival and the cellular stress response and how exploiting these pathways may provide new cancer therapeutics.

The symposium on Cellular responses to cellular damage in Schizosaccharomyces pombe will take place on 1 - 4 October 2007.

Bethesda, Md., Thurs., Sept. 11, 2014 - Building on a successful three - year pilot project, the National Institutes of Health has awarded more than $ 64 million to six research institutions to create a database of human cellular responses, the Library of Integrated Network - based Cellular Signatures (LINCS).

Working with Inovio Pharmaceuticals, Duke University, Emory University, University of Massachusetts and the National Institutes of Health, the group aims to build on the success of previous generations of DNA vaccines in order to induce strong cellular and humoral responses.

Over the past few years, they have extended their research to understand how products of cellular necrosis and the innate immune responses they induce affect the tumor microenvironment, with a specific focus on ovarian cancer.

DNA sequences designed to either stimulate a specific immune response or to down - regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.

Glycan functionalised NPs offer several advantages: (i) their synthesis can be performed under biomimetic conditions resulting later on in nanoparticles without traces of chemicals responsible for adverse cellular responses.

Immunogenicity and efficacy studies in pig (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

(ii) the carbohydrates on the surface can serve as targeting molecules and trigger cellular uptake via specific receptors or mediate specific cellular responses [10].

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

By practicing specific yoga poses, we place certain amounts of therapeutic stress (called the «Goldilocks Position») on our connective tissues, gently creating tiny piezoelectric currents that in turn stimulate optimal cellular responses.

'» Another group of researchers agrees, writing in Dermatology Research and Practice that there are two theories for aging: the first «focuses on reduced cellular lifespan, decreased responsiveness and functionality, and dysfunctional immune responses,» while the second «points towards environmental damages, focusing on DNA damage, inflammation and free radical formation.»

Are there any respectable studies that show, on a cellular level, that slow fiber is slow, and nothing else, that fast fiber is fast and nothing else, or could these be just particular adaptations that single fibers are capable of in response to the tasks put before them?

Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle.

Modulatory effects of vagal stimulation on neurophysiological parameters and the cellular immune response in the rat brain during systemic inflammation

(They all log on with their own cellular devices and receive immediate feedback, complete with a leaderboard and bonus points for correct - streaks and quick responses... it's really quite an exciting way to review!)

These yeast based all natural ingredients have been developed or improved using the advanced science of Nutrigenomics which measures response of nutrients on a cellular level.

Her research was focused on the genetic and cellular response to cardiac injury such as heart attack.

In response to these widespread issues with the phone app and cellular reception, Samsung has completely pulled the Beta 2 update in the US for users on T - Mobile, Sprint, and the Unlocked model.