Humans evolved Coordinator mutations that are good at turning on human versions of genes, but not so great at turning
on chimp genes.
Chimp Coordinators, on the other hand, easily turn
on chimp genes but don't work as well for human genes.
Not exact matches
While
chimps have only two copies of the salivary amylase
gene (one
on each of the relevant chromosome pair), humans have an average of six, with some people having as many as 15 (Nature Genetics, vol 39, p 1256).
The human (and all the other) genome projects were predicated
on the reasonable assumption that spelling out the full sequence of
genes would reveal the source of that diversity of form and attributes that so readily distinguish worm from fly, mouse,
chimp and human.
And it's precisely some of those
genes, the ones involved in neural development, that appear
on the list of differences between the
chimp and human genomes.
Then for HARE5, the most active enhancer in an area of the brain called the cortex, they made minigenes containing either the
chimp or human version of the enhancer linked to a «reporter»
gene that caused the developing mouse embryo to turn blue wherever the enhancer turned the
gene on.
Since a rough draft of the
chimp genome became available in 2005, much research has focused
on human
gene sequences that are missing in apes.
Differences in
gene expression may have given us bigger brains, but in this movie scene, the
chimp comes out
on top.
The competition to attract a mate, as well as internal sperm competition, puts intense pressure
on chimp male
genes to evolve rapidly.