Sentences with phrase «on chromatin»

Over the years his research has focused on chromatin structure, its modifications and their role in gene regulation, and he has partnered to publish, in his career, over 153 papers.

But we soon saw that there were some highly - expressed genes that did not have the epigenetic marks on their chromatin — which are thought to be required to maintain such high levels of expression.

Using computational and epigenomic methods, the team found that TCF - 1 behaved in a similar manner on the chromatin of individual T cells.

Multiple modifications (acetylation, methylation, ubquitination, phosphorylation) of multiple histones (5 major families) combined with a multitude of effects on chromatin give rise to a complex «histone code» that signals the transcriptional machinery to turn genes on or off.

A protein that acetylates core histones, resulting in important regulatory effects on chromatin structure and assembly, and on gene transcription.

A similar mechanism may be employed by many other enzymes operating on chromatin, given that they contain similar components of a feedback loop.

Using sophisticated biochemical and sequencing methods, Dou found that laminB1, a key component of the nuclear lamina, and LC3 were contacting each other in same places on chromatin.

LC3 directly interacts with lamin B1 and binds to lamin - associated domains on chromatin.

«At the present, we already have computer models that help us to predict the patterns of expression for genes based on their chromatin modifications.

Explore data and information published by the scientific community on chromatin biology mapped onto phylogenetic trees.

Her thesis was entitled «Impact of copy number variation on chromatin interactions at the mouse 4qE2 chromosome region.»

As part of a large collaborative experimental group studying the genetic basis of neuropsychiatric disorders, his work centers on chromatin modeling and epigenetic factors in this disease spectrum using human cellular models.

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

Thus, such mutations might alter the protein function on chromatin state regulation, sensitizing PTCL - NOS patients to HDAC inhibitors.

To respond to a cell's need at any given time, a limited number of proteins touch down on the chromatin packaging of DNA to unlock a gene or change its activity.

The American Society for Biochemistry and Molecular Biology hosts its biennial symposium on chromatin and RNA polymerase II in early October at the Snowbird Ski and Summer Resort in Utah.

To accomplish this, we will conduct genome scale capture experiments on chromatin samples from flies, mice and humans.

In contrast to repression by HP1, which served as a positive control for repression, the effect of ACF1 strongly depends on the chromatin context and is particularly robust in lowly expressed genes in overall inactive chromatin domains.

His research focuses on chromatin, epigenetics, and small molecules to change cell fates, with a particular focus on generating new insulin - producing beta cells from other cell types.

Lausanne, Switzerland About Blog Epigenomics and Epigenetics queries the developmental origins of health and disease by cataloguing the sets of physical markings on chromatin that collaborate to stably alter gene expression.

Gene expression is regulated by epigenetic chemical modifications (including methylation and acetylation) on chromatin — histone proteins tightly associated with DNA.

Cancer studies have increasingly focused on chromatin — the intertwined proteins and DNA that are packaged into chromosomes — because of its ability to regulate genes important for either activating or inhibiting tumorigenesis.

The idea is that small chemical tags, such as acetylation, on chromatin marking active or inactive genes would self - propagate independently of the underlying DNA sequence and direct the activity of the genome.

A major part of the Panne lab focuses on chromatin and its role in gene regulation.