Sentences with phrase «on chromatin structure»

Over the years his research has focused on chromatin structure, its modifications and their role in gene regulation, and he has partnered to publish, in his career, over 153 papers.

A protein that acetylates core histones, resulting in important regulatory effects on chromatin structure and assembly, and on gene transcription.

Not exact matches

The 50 - year partnership of Donald and Ada Olins is based on good communication and a shared passion for chromatin structure.

At the same time, coauthor Peter Adams, from the University of Glasgow, published a previous study on the breakdown of the nuclear lamina in which he observed a peculiar protrusion, or blebbing, of the nuclear envelope into the cytoplasm, and these blebs contained DNA, nuclear lamina proteins, and chromatin (the nuclear structures in which genes reside).

Depending on the tissue type and what jobs that tissue is doing, distinct portions of DNA are unspooled to become available for activity through a structure called open chromatin, said Gregory Crawford, an associate professor of pediatrics and expert on gene expression.

«The key lesson we learned was that the genes that are destined to be turned on specifically in the fertilized egg are covered by this unique chromatin domain structure,» says Ren.

What O'Shea's team saw, in both resting and dividing cells, was chromatin whose «beads on a string» did not form any higher - order structure like the theorized 30 or 120 or 320 nanometers.

DNA is condensed on histones, creating a structure called chromatin.

We focus on how changes in chromatin structure orchestrate the developmental transitions from fertilization to genome activation to cell fate specification.

Our laboratory will focus on applying new synthetic and chemical biology methods to understand chromatin structure and function.

Steve's research focuses on polyploid crops where he uses genomics and bioinformatics approaches to examine chromatin structure and the effect it has on gene regulation.

We interfere with histone modification marks in vivo, both genome - wide (mutant analysis) and gene - specifically (local disruption of chromatin structure), and analyze the effect on transcription and pluripotency.

Chromatin folds into secondary structures (loops) and tertiary structures (globules) to achieve exquisite compaction — on the order of 700 terabytes per gram — and form the X-shaped chromosomes we all know and love.

«This discovery will advance our understanding of stem cell epigenetics and chromatin structures, provide potential mechanisms on maintaining the hallmark properties of ES cells, and help researchers with the rich source of information to better understand some of the unique features — such as self - renewal and pluripotency — of human embryonic stem cells,» said Ng Huck Hui, Ph.D., senior group leader at GIS and a member of the Singapore team that conducted this research.

ATP - dependent chromatin remodelers are enzymes specialized on altering the structure and packaging state of chromatin.

A rare, premature aging disease, Hutchinson - Gilford progeria is caused by a single point mutation in the gene encoding lamin A, which forms a protein scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes such as RNA and DNA synthesis.

Epigenetic factors act on the structures in which genes reside, called chromatin.