Sentences with phrase «on chromosome number»

The research team showed that extra genetic material on chromosome number 8 caused the condition in two families from Manchester.

Not exact matches

After analyzing both scans together for DNA variants associated with differences between when each patient's movement - associated symptoms first appeared and when they would have been expected based on the number of CAG repeats, MGH CHGR investigator and lead author Jong - Min Lee, PhD, identified two locations on chromosome 15 where variants were significantly associated with either early or late symptom onset.

They found that the number of copies of lncRNA genes on a chromosome consistently change in 12 different cancer types and lncRNA genes are widely expressed in cancer cells.

Venken first sought a vector that could handle large amounts of DNA efficiently, settling on a bacterial artificial chromosome, which was designed a couple years ago and is known to maintain only a few copies of the DNA (though it can produce a high number of copies if it is induced).

Dr Siddharth Banka, Clinical Senior Lecturer at the Manchester Centre for Genomic Medicine, who led the study, explained: «Our team has identified that this new syndrome is caused by a small deletion on chromosome 6 that affects the function of hypothalamus, a region of the brain that plays a number of important roles in the body.»

In the illustration, each tissue type is followed by the number of genes whose level of activity is controlled by nearby genes on the same chromosome (cis); those whose activity is associated with genes on other chromosomes (trans); and the number of tissue samples studied.

Rather gene dosage, which depends on the number of chromosome copies, is responsible for this: «If the chromosome is multiplied, then more copies of the same gene will be transcribed.

Scientists first reported a link between a surplus of genetic material on chromosome 15 and autism in 1994, a finding that has since been replicated and confirmed to be a copy number variation.

It helps to lengthen the telomeres — the proteins and DNA on the ends of chromosomes that prevent dividing chromosomes from fraying — and therefore increases the number of times a cell can divide.

Some research teams over the past five years have used microarray or gene - chip technology to compare genomes and quickly scan them for variations of copy numbers on each chromosome.

While the bulk of this project was focused on autism, this project began when Zylka and Yi noticed that a large number of Angelman syndrome - linked mutations were clustered in the same chromosome region where the phosphate group was tacked onto UBE3A.

Chromosome numbers are indicated on the left.

Surveillance that is not stringent enough, on the other hand, would allow eggs with a lot of jumping gene - related errors to survive, and lead to a high level of birth defects, such as those caused by an incorrect number of chromosomes in the offspring.

Her thesis was entitled «Impact of copy number variation on chromatin interactions at the mouse 4qE2 chromosome region.»

They noted also that the number of chromosome sets (ploidy) in the yeast cells had an impact on fitness across all of those species tested.

The colors and corresponding numbers on the mouse chromosomes (L) indicate the human chromosomes (R) containing homologous (similar) segments.

But 90 percent of our genes are not on the X chromosome,» Walsh says, adding that genes located elsewhere that cause intellectual disability probably number in the hundreds, but are much more difficult to identify.

The resulting DNA copy number variation and patterns of chromosome loss and gain are tumor - type specific, suggesting differential selective pressures on the two tumor cell types.

The coding sequences (Genbank Accession number HQ110882) of both of these are in 100 % agreement with the public domain assembled canine genome on Chromosome 7: 22,632,147 — 22,638,970.