The technique, described in Biomaterials, uses gold nanoparticles and Raman scattering, a technology previously developed by Qian and Nie for cancer cell detection (2007 Nature Biotech paper, 2011 Cancer Research paper
on circulating tumor cells).
The study focuses
on circulating tumor cells, a potentially rich source of information about a person's cancer.
Not exact matches
Further research could test these cancer stem
cell gene expression at the RNA and protein level in
circulating tumor cells and biopsies from patients
on trial.
Currently, in another study, the researchers are focused
on detecting
circulating tumor cells in the blood of patients with a diagnosis of breast cancer.
The technique typically homes in
on circulating -
tumor DNA (ctDNA), genetic material that routinely finds its way from cancer
cells into the bloodstream.
The results were published in the journal Lab
on a Chip (Lab
on a Chip 17 (19), 3291 - 3299) in an article called: «Magnetic particles assisted capture and release of rare
circulating tumor cells using wavy - herringbone structured microfluidic devices.»
Liu's «lab
on a chip» is notable for its ability to not only capture
tumor cells circulating in the blood, but to «release» those
cells as well.
An additional advantage to the new subtyping is that it can be performed
on tumor cells circulating in the blood.
«The big surprise,» Discher said, «is that injected macrophages
circulate all around the body but accumulate only within the
tumors where they engorge
on cancer
cells.»
«Our chip is currently the only device that can potentially capture
circulating tumor cells and exosomes directly
on the chip, which should increase its ability to detect metastasis.
We have invented new biomaterial surfaces based
on natural halloysite nanotubes, that capture rare
circulating tumor cells (CTCs) from blood while simultaneously repelling white blood
cells.