Lin, L. C., Que, J., Lin, K. L., Leung, H. W., Lu, C. L., and Chang, C. H. Effects of zinc supplementation
on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double - blinded randomized study.
The researchers designed the study, called Effect of Remote Ischemic Preconditioning
on Clinical Outcomes in Coronary Artery Bypass Grafting Surgery (ERICCA), in an effort to find new ways to improve bypass outcomes for high - risk patients.
«TOPCAT is the first randomized, double - blind trial to assess the effect of a treatment - spironolactone -
on clinical outcomes in this patient demographic.»
RELAX - AHF was a randomised, double blind controlled trial that evaluated the effects of a 48 - hour infusion of the intravenous drug, serelaxin,
on clinical outcomes in 1 161 patients admitted to hospital for acute heart failure.
In three new studies in the current issue of the International Journal of Infectious Disease, researchers reported
on clinical outcomes in the Kingdom of Saudi Arabia (KSA), how long patients will shed virus during their infections, and how the Sultanate of Oman is dealing with cases that have appeared there.
The TOPCAT trial is the first randomized, double - blind trial to assess the effect of spironolactone
on clinical outcomes in these patients with heart failure and preserved ejection fraction.
This calls for a further urgent clarification of its impact
on clinical outcome in humans.
Not exact matches
These risks and uncertainties include, among others: the unfavorable
outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from
clinical trials may be interpreted by the FDA
in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our
clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine;
clinical development activities may not be completed
on time or at all; the results of our
clinical development activities may not be positive, or predictive of real - world results or of results
in subsequent
clinical trials; regulatory submissions may not occur or be submitted
in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction
in payment rate or reimbursement for the company's products or an increase
in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors»
in the company's most recent Annual Report
on Form 10 - K and
in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available
on the SEC's website at www.sec.gov.
This stage represents the final effect of the event
on the clinician, who may leave the
clinical profession altogether, stay
in her previous role but never function at her previous performance level, or thrive by taking lessons learned and working to ensure that deficits
in the process led to the
outcome are addressed
in effort to decrease the likelihood that such an event will occur.
The workshop featured presentations from invited speakers and discussions to highlight research findings that advance our understanding of the effects of maternal care services
in different types of institutional settings
on maternal labor,
clinical and other birth procedures, and birth
outcomes.
Moreover, robust evidence
on the cost effectiveness of birth
in alternative settings is a priority, as was highlighted by the recent National Institute for Health and
Clinical Excellence (NICE) clinical guidance on intrapartum care.11 The Birthplace in England research programme was designed to fill gaps in research evidence about the processes and outcomes associated with different settings for birth in the NHS in
Clinical Excellence (NICE)
clinical guidance on intrapartum care.11 The Birthplace in England research programme was designed to fill gaps in research evidence about the processes and outcomes associated with different settings for birth in the NHS in
clinical guidance
on intrapartum care.11 The Birthplace
in England research programme was designed to fill gaps
in research evidence about the processes and
outcomes associated with different settings for birth
in the NHS
in England.
The definition of low risk used
in the cohort study was based
on criteria contained
in the NICE Intrapartum Care Guidelines.11 The primary
clinical outcome was a composite measure of adverse perinatal
outcomes encompassing perinatal mortality and specified neonatal morbidities (box).
Low family income during the early childhood has been linked to comparatively less secure attachment, 4 higher levels of negative moods and inattention, 5 as well as lower levels of prosocial behaviour
in children.2 The link between low family income and young children's problem behaviour has been replicated across several datasets with different
outcome measures, including parental reports of externalizing and internalizing behaviours,1 - 3, 7 -9,11-12 teacher reports of preschool behavioural problems, 10 and assessments of children based
on clinical diagnostic interviews.7
Because the trial found no differences
in the effect of type of care
on any primary
clinical outcome, the economic analysis compares only the costs of care rather than their cost - effectiveness.
The risk status of a pregnancy was defined using a mixture of maternal International Classification of Disease (ICD) codes [19] and individual fields
in the SMMIS database, and was based
on a 2007
clinical guideline from the National Institute for Health and Clinical Excellence (NICE) which contained lists of medical and obstetric conditions which indicate increased risk of negative pregnancy outcom
clinical guideline from the National Institute for Health and
Clinical Excellence (NICE) which contained lists of medical and obstetric conditions which indicate increased risk of negative pregnancy outcom
Clinical Excellence (NICE) which contained lists of medical and obstetric conditions which indicate increased risk of negative pregnancy
outcomes [20].
Ms. McBride received her law degree from George Washington University Law School and her Master's Degree
in Evaluative
Clinical Sciences (a program focused on health policy considerations of clinical outcomes) from Dartmouth
Clinical Sciences (a program focused
on health policy considerations of
clinical outcomes) from Dartmouth
clinical outcomes) from Dartmouth College.
The Effect of Timing of Cord Clamping
on Neonatal Venous Hematocrit Values and
Clinical Outcome at Term: A Randomized, Controlled Trial José M. Ceriani Cernadas, Guillermo Carroli, Liliana Pellegrini, Lucas Otaño, Marina Ferreira, Carolina Ricci, Ofelia Casas, Daniel Giordano and Jaime Lardizábal Pediatrics 2006; 117; 779 - 786; originally published online Mar 27, 2006; DOI: 10.1542 / peds.2005 - 1156 Download file
in 380 kb - 10 pages The online version of this article, along with updated information and services, is located
on the World Wide Web at: http://www.pediatrics.org/cgi/content/full/117/4/e779 Background: The umbilical cord is usually clamped immediately after birth.
«We are currently working with people from across the field of cancer to develop a new Cancer Reform Strategy, which will set out the plans for cancer services
in England over the next five to ten years, building
on progress so far by spreading best practice and recommending what more needs to be done to improve
clinical outcomes, drive up quality and increase value for money.»
Let me point to 10 things that I sketched out this morning: too much money spent
on administration and bureaucracy and not enough
on front - line patient care; too little patient - centric information to inform decision making; too little innovation; too little
clinical input into decision making; too much inertia and hostility to reform, as we have seen today; too much process - driven target culture distorting
clinical decision making; falling productivity; poor
outcomes across a range of
clinical indicators; too often, weak commissioning of servicing; and widening health inequalities
in the past 10 years,
in addition to the scandals that occurred
in Staffordshire and Kent.
In health, information
on the prescribing data and comparative
clinical outcomes of GP practices will be published from December this year.
When subsequent studies found that CellSearch results had no influence
on clinical outcomes, though, insurers lost interest
in paying for it.
«This gives us an underlying candidate biomarker panel that provides information
on the subsequent
clinical outcome or therapeutic efficacy, which can be validated to yield a final panel, then translated into say, an ELISA - based kit or some other immunodiagnostic format
in the
clinical setting,» says Dorfman.
They now must await the
outcome of the next candidate
in the pipeline of more than 30 products
in clinical testing and mine the STEP data for clues
on ways to develop one that works.
«While the presence of lymphocytes
in tumors is often associated with better
clinical outcomes, this research adds clarity
on the diversity of T cells within the tumor environment and their influence
on ovarian cancer
outcomes,» says first author Kunle Odunsi, MD, PhD, FRCOG, FACOG, Deputy Director, M. Steven Piver Professor and Chair of Gynecologic Oncology, and Executive Director of the Center for Immunotherapy at Roswell Park.
In 22 percent of cases, the additional clinical information found in the EHR was rated as «possibly» having a clinically significant impact on the interpretation of the head CT. «This study exemplifies the power of EHR's and their potential impact on patient care and positive outcome
In 22 percent of cases, the additional
clinical information found
in the EHR was rated as «possibly» having a clinically significant impact on the interpretation of the head CT. «This study exemplifies the power of EHR's and their potential impact on patient care and positive outcome
in the EHR was rated as «possibly» having a clinically significant impact
on the interpretation of the head CT. «This study exemplifies the power of EHR's and their potential impact
on patient care and positive
outcomes.
Besides working at IBM's Thomas J. Watson Research Center
in Yorktown Heights, New York, Meyer heads something called the DREAM challenges, contests that ask teams of computer scientists to solve outstanding biomedical problems, such as predicting the
outcome of prostate cancer treatment based
on clinical variables or detecting breast cancer from mammogram data.
An investigation into how patient
outcomes are assessed
in clinical trials has revealed a worrying lack of consistency, raising concerns about funding being wasted
on the acquisition of poor quality data.
The study, Developing an Interventional Stroke Service: Improving
Clinical Outcomes and Reducing Cost and Delivering Great Cost Savings Benefits to Health Economy, conducted at the University Hospital of North Midlands, Stoke -
on - Trent, U.K., found that mechanical thrombectomy (the use of a device to retrieve a clot from the vessel)
in the treatment of stroke reduced the average stroke patient's hospital stay to 14 days when compared to previously recorded 90 days.
The UB researchers are conducting a longitudinal, five - year study of these patients focused
on the relationship between cerebral microbleeds, advances
in magnetic resonance imaging and
clinical outcomes.
«Using an algorithm based
on genetic testing to guide treatment is sustainable and associated with better
clinical outcomes in a real - world
clinical practice, although it is difficult to consistently maintain,» said Craig R. Lee, Pharm.D., Ph.D., F.A.H.A., associate professor of pharmacy at the University of North Carolina at Chapel Hill Eshelman School of Pharmacy.
Since L - arginine can be given to women as a simple, safe, and inexpensive food supplement, (
in peanuts, for example)
in pregnancy, Dr. Kain and Dr. McDonald are now planning human
clinical trials to assess its impact
on human birth
outcomes.
In a new study, a hospital surveillance program focusing
on reducing the risks of sepsis, known as the two - stage
Clinical Decision Support (CDS) system, was found to reduce the risk of adverse
outcomes, such as death and hospice discharge for sepsis patients, by 30 % over the course of one year.
However,
in analyses that accounted for important patient characteristics such as age, sex, comorbidities, and the reason for hospitalization, the quality of care of the discharging hospital and SNF facility characteristics,
outcomes did not vary meaningfully across SNFs that differed
in staffing ratings or their performance
on clinical measures related to pain or delirium.
Yang et al. report
on one such strategy: Taking the knowledge that an increase
in type I interferons (IFNs) correlates positively with
clinical outcome in several cancers and that type I IFNs can enhance antitumor immunity
in some models, the authors tethered IFN - β to a monoclonal antibody targeting the epithelial growth factor receptor (EGFR), which is approved for use
in treating metastatic colorectal cancer and head and neck cancer.
«The recent niacin
clinical trials offer important new evidence that raising «good» cholesterol (HDL) levels
on top of statin therapy does not have the positive
outcome that had been hoped for,» said Neil Stone, M.D., the Robert Bonow MD Professor
in Cardiology at Feinberg and a cardiologist at Northwestern Memorial Hospital.
«This is the first national study to identify specific regions of the United States where residents may be at an increased risk for poor
clinical outcomes — including misdiagnoses and late detection — as a result of limited access to specialized gynecologic cancer care,» says David Shalowitz, MD, a fellow
in the division of Gynecologic Oncology at the Perelman School of Medicine at the University of Pennsylvania, and lead author
on the study.
The study is investigator led and has therefore focused
on clinical need, targeting patients with progressive multiple sclerosis
in whom most disability is incurred... The study also reports a predominant effect
on neurodegenerative rather than inflammatory
outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin
on sustained disability, particularly
in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»
However, the authors stress that «further
clinical investigations will be essential to establish the optimal dose, duration and safety, and whether vitamin D2 or D3 have different effects
on mortality risk, since the available trials are based
on elderly populations
in general (an age group with high competing risk of death often due to multiple co-existing disease conditions) and they do not typically include cause - specific deaths as the primary
outcomes.»
On the other hand patients with DRB1 * 04:01 have a better
clinical outcome in the short - and long - term suggesting that human leukocyte antigen (HLA) analysis and screening for SLA / LP antibodies should be integrated
in the
clinical routine for AIH diagnosis.
Since blood samples are taken and frozen with many
clinical trials, this allows them «almost a bit of a time machine» to go back and explore questions around pain or neuropathy to run tests
on neurons created from blood samples of patients taken
in past
clinical trials where responses and
outcomes have already been recorded.»
«Additional research is needed to determine how these recommendations might be implemented
in clinical practice and to understand the impact
on patient
outcomes.»
«Given the continued high prevalence of multivitamin use
in the US, it remains critical for us to understand its role
on nutritional status and other long - term health
outcomes through
clinical trials such as PHS II and other new research initiatives.»
Up until now, efforts
in generating a vaccine against TB have been mainly focused
on T cells (cells from the adaptive arm of our immune response with memory capacity), with very disappointing
outcomes in both pre-
clinical as well as
clinical trials.
The study wasn't designed to measure whether tumor profiling made a difference
in how patients fared, but «it nonetheless lays the groundwork for more systematic study of the impact of genomics
on clinical practice and patient
outcomes,» the report said.
«But although it has been shown to help reduce injury to the heart during surgery and
in other medical contexts, unfortunately it showed no benefit
on long - term
clinical outcomes in our study of patients undergoing cardiac bypass surgery.»
«Many
clinical trials
in pulmonary hypertension also use the catheter test as an
outcome measure, but it could provide a significant advantage to be able to replace it with a less invasive MRI scan, as our model also provides more detailed information
on physical changes to the heart itself.»
The research, one of a number of studies to explore the connection between heart disease and development of depression by researchers at Intermountain Medical Center Heart Institute, will be published
on July 28
in the European Heart Journal — Quality of Care &
Clinical Outcomes.
«Diabetes raises the risk about twofold for Alzheimer's disease,» says senior author, Gail Musen, Ph.D., Assistant Investigator
in the Section
on Clinical, Behavioral, and
Outcomes Research at Joslin Diabetes Center.
Gail Musen, Ph.D., is an Assistant Investigator
in the Section
on Clinical, Behavioral, and
Outcomes Research and an Assistant Professor
in Psychiatry at Harvard Medical School.
The effect of hepatic impairment
on outcomes in phase 1
clinical trials
in cancer subjects.