Athenex, which raised $ 68 million from a secondary stock offering during the quarter, finished the year with $ 51 million in cash and short - term investments, down from $ 69 million in September as the company spent heavily
on clinical trials for the drugs it is developing and absorbed higher licensing fees at its specialty drug business, which has added 12 new drugs to its stable of products.
Not exact matches
Following a devastating
clinical trial setback earlier this month
for its lead experimental product, a cannabidiol gel, in epilepsy, the firm reported another
trial failure
on Monday
for the product in treating knee pain due to osteoarthritis.
The striking example I focused
on then was the cancer drug Avastin, developed by Genentech (now Roche)-- which, at the time, had been studied in at least 400 completed human
clinical trials for various cancers.
The latest
clinical trial outsourcing / drug development and manufacturing merger hit
on Monday as scientific instrument giant Thermo Fisher announced it would buy drug ingredients maker Patheon
for $ 5.2 billion ($ 7.2 billion is you count $ 2 billion in net debt).
Shares of cancer - focused biotech Clovis Oncology soared nearly 50 % in early Monday trading
on the strength of
clinical trial results
for its ovarian cancer treatment Rubraca.
The approval was based
on two
clinical trials of the device and lowers the barrier of entry
for other similar devices, by establishing criteria that classify these systems as moderate risk medical devices, the FDA announced.
These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from
clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings
for our products, including our
clinical trial designs, conduct and methodologies and,
for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine;
clinical development activities may not be completed
on time or at all; the results of our
clinical development activities may not be positive, or predictive of real - world results or of results in subsequent
clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement
for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report
on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available
on the SEC's website at www.sec.gov.
And Marathon barely did any actual
clinical legwork to get the drug cleared
for Duchenne — it relied
on 1990 - era
clinical trial data before tacking
on just enough study material to win an approval that doesn't even address the root cause of the disease.
But while thousands of
clinical trials on immunotherapy drugs, of which many are predicted to fail, are springing up, the depth of information
on neoantigen vaccines is much shallower: Just two studies
on neoantigen vaccines
for melanoma, recently profiled in Nature, were completed last year in Boston and Germany.
Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in
clinical testing; Alder's ability to conduct
clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the
clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing
on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report
on Form 10 - K
for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC)
on February 26, 2018, and is available
on the SEC's website at www.sec.gov.
The biotech plans to shed 20 % of its nearly 600 employees in order to secure yearly cost - savings of about $ 21 million — money which can then be used to double down
on late - stage
clinical trials for its experimental Parkinson's drug.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues
for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement
for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required
on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding
for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from
clinical trials involving investigational compounds; Gilead's ability to initiate
clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications
for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all,
for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from
clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact
on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
* MEDICINES360 AND ALLERGAN PRESENT 5 - YEAR
TRIAL DATA FROM LARGEST
ON - GOING IUS
CLINICAL STUDY Source text
for Eikon: Further company coverage:
After Abbott, he co-founded DCVC company BlueTalon, which was initially focused
on enterprise data security
for data - driven
clinical trial design and population health management.
The Blockchain
for Clinical Trials Forum will take place
on February 12 at the Orlando Science Center in Florida and will bring together prominent healthcare industry stakeholders.
The flagship drug of San Diego's MediciNova failed a midstage
clinical trial for methamphetamine dependency, casting doubt
on prospects
for a product it has placed great hopes in.
Juno asserted that the
clinical hold
on the ROCKET
trial did not affect plans
for its other CD19 - directed CAR T - cell product candidates, including JCAR017,
for which the company has launched two
clinical trials now recruiting patients.
For the second time in 5 months, Juno Therapeutics has put a
clinical hold
on a Phase II
trial of JCAR015 in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia due to patient deaths.
Juno Therapeutics is seeking to change the protocol
for the Phase II ROCKET
clinical trial of its acute lymphoblastic leukemia candidate JCAR015, which the FDA has placed
on clinical hold following the deaths of three patients, two of them last week.
Pharmaceuticals: Reflects Canada's existing regimes, systems and laws
on: patent linkage; protection
for clinical trial data; and early working exceptions.
Motif has successfully concluded a second phase III
clinical trial on its lead drug, iclaprim and is preparing
for regulatory...
Given the
clinical trial results underpinning a new drug application
for Kite Pharma's lead candidate, which the Food and Drug Administration is currently reviewing, I'd say there's a solid chance Gilead can squeeze out a return
on its investment.
Most biotechs would have shuttered a
clinical program that showed absolutely no efficacy whatsoever in a late - stage
trial, but Novavax has instead doubled down
on RSV by going forth with its phase 3
trial of the RSV F vaccine
for infants via maternal immunization, and begun planning
for another
trial in older adults that's reportedly
on track to kick off in 2018.
In this randomized, double - blind
clinical trial, virgin coconut oil was the clear winner: «among pediatric patients with mild to moderate AD, topical application of virgin coconut oil
for eight weeks was superior to that of mineral oil based
on clinical (SCORAD) and instrumental (TEWL, skin capacitance) assessments.»
Some thoughts
on new treatments being investigated
for Coeliac Disease, and the
clinical trials required to bring them to market.
Additionally, in a
clinical trial Axiom's signature, hexane - free and non-GMO Oryzatein ® rice protein, showed that plant - based rice protein rivals dairy - based whey
for muscle building, fat reduction and muscle repair
on March 9, 2013.
The study comes
on the heels of a 2013
clinical trial that showed rice protein paralleled whey protein in its ability to build muscle and improve strength and power
for the first time.
Although a considerable body of scientific evidence substantiates the positive correlation between curcumin consumption and a reduction in the risk of cancer, the paucity of suitably designed human
clinical trials that clearly demonstrate any direct effect of curcumin
on cancer markers may prevent Health Canada from approving a cancer risk reduction claim
for curcumin within the current regulatory framework.
«There's more emphasis now and there will be more emphasis because of the Affordable Care Act [
on] offering mental health services in primary care settings,» suggests Curry, who is about to start a
clinical trial looking at the effects of cognitive behavior therapy
for adolescents with depression and substance abuse problems.
Collectively, the evidence from longitudinal research,
clinical trials, and neurodevelopmental research is beginning to provide a compelling case
for the view that breastfeeding may have longer - term effects
on individual cognitive ability and educational achievement.
Philips Avent has been a reliable household brand since 1984, and the company relies
on research and
clinical trials to create and enhance their products to deliver the most satisfactory results
for your child.
The widespread assumption of safety has led researchers in fetal behaviour to assure women volunteering
for clinical trials that ultrasound exposure of one to one - and - a-half hours (sometimes
on more than one occasion) is safe
for their unborn babies - yet we know of no follow - up of these exposed children.
Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation
for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized
clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration
for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth)
on exclusive breastfeeding at 1 month of age and
on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.
While anecdotal and
clinical experience supports improvement in milk production
for women with insulin resistance who start or resume metformin, Vanky and colleagues (Vanky, Nordskar, Leithe, Hjorth - Hansen, Martinussen, & Carlsen, 2012) reported after a randomized, controlled
trial that metformin had no effect
on breast changes / size increase in pregnancy or breastfeeding in women who were obese.
Shares plummeted Tuesday by more than 90 percent
on a failed
clinical trial for its multiple sclerosis treatment.
Glenis herself had received an award
for her work
on encouraging medical research and transparency of
clinical trial results.
He serves
on the House Energy and Commerce Committee's Health Subcommittee, and last year he authored a section of important health legislation that speeds the process
for new drugs to be approved through
clinical trials.
The FDA reviews more liver health data and approves duloxetine
for depression and diabetic neuropathy (pain), based
on another set of
clinical trials.
«When they brought me
on board, the need was
for production capability
for clinical trials.
Fiers discovered a key protein
on the influenza virus that could serve as a target
for a universal vaccine; the drug has shown promise in an early
clinical trial.
AveXis, Inc., a
clinical - stage gene therapy company developing treatments
for patients suffering from rare and life - threatening neurological genetic diseases, announced in July 2016 that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation
for the treatment based
on preliminary
clinical results from the
trial of AVXS - 101.
Lanza says that this time, he aims to do things right: direct good science focused
on treating disease, publish in reputable journals with rigorous peer - review processes and work with high - quality collaborators and
clinical centres
for its
trials.
Also, FDA clears the party drug ecstasy
for post-traumatic stress disorder
clinical trials, and U.S. courts rule that the federal government must consider the impacts of major energy projects
on climate change.
«Our results indicate it is a promising agent
for clinical trials, and a as an add -
on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.»
GTC recognized the need to demonstrate
on its own the potential
for the technology and, in the late 1990s, began a
clinical trial of human antithrombin
for patients undergoing bypass surgery who develop resistance to the anticoagulant drug heparin.
Clinical trials for targeted therapies, selected
on the basis of the genomic tests, are scheduled to begin in early 2007.
The result will be corresponding data representations
for clinical and
trial data, both based
on the RIM.
In the newly reconstituted Scientific Responsibility, Human Rights, and Law Program, the missions of the CSFR and NCLS continue to complement one another as staff pursue projects such as continuing seminars
for judges
on neuroscience and the law, personalized medicine, the state and future of
clinical trials, advocacy in science, understanding responsible research practices in changing research environments, and joint AAAS - China Association of Science and Technology workshops
on science and ethics.
The team is now calling
for a much larger
clinical trial, involving one quarter of a million women, to investigate the effect of the screening using HPV testing
on cancer rates.
The company hopes that early next year it will initiate
clinical trials on product safety, which will pave the way
for human efficacy testing that could be completed by 2011.