Sentences with phrase «on colon cancer development»
We examined the effects of three HFDs differing in the percentage of total calories from saturated fat (SF)(6 %, 12 %, and 24 % of total caloric intake), but identical in total fat (40 %), and a commercially available Western Diet (26 % and 41 % saturated and total fat, respectively) on colon cancer development using the AOM / DSS murine model.
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When comparing the effects of these diets to cancer development in specific subsites of the colon, they found that those regularly eating red meat compared to a red meat - free diet had higher rates of distal colon cancer — cancer found on the descending section of the colon, where feces is stored.
In the study, published online on February 4 in the journal Cell Stem Cell, Duke biomedical engineers show how colon cancer development is intricately linked to a specific microRNA that dictates how cells divide.
The laboratory broadly focuses on the biology of sporadic and hereditary colon and rectal cancer development, progression, and response to therapy.
On the other hand, genetic mutations that further promote the growth of intestinal stem cells are associated with uncontrolled organ regeneration and the development of colon cancer.
Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.