Sentences with phrase «on cytochrome»

Atovaquone (ATO) is a safe and potent antimalarial drug that acts on cytochrome b (cyt.

Not exact matches

biochemical evidence such as Cytochrome - cyto - C is just one of the thousands of sequences and is not proof of common ancestry, as there are more variations than similarities in the genetic code, on the other hand a study of the amino acid make - up reveals that man is closer to lamprey than are fish.

They secrete a substance called cytochrome c that switches on a messenger protein that latches onto the caspaces and jars them awake.

From a genetic screen, we found that the cytochrome P450 oxygenase CYP - 13A12 acts in response to the EGL - 9 — HIF - 1 pathway to facilitate the O2 - ON response.

Some cytochrome p450 enzymes act on polyunsaturated fatty acids to make cellular signaling molecules known as eicosanoids.

They knocked out the gene on G. sulfurreducens that produces cytochromes.

«Antibody - recognition force microscopy shows that outer membrane cytochromes OmcA and MtrC are expressed on the exterior surface of Shewanella oneidensis MR - 1.»

Why it matters: Electron transfer by MtrC, an outer membrane cytochrome on S. oneidensis, can stabilize contaminants, mitigating their impact on the population and environment.

The symposium will focus on the roles of the major enzymes participating in metabolism of xenobiotics including carcinogens and drugs — the membrane monooxygenase systems containing cytochromes P450 — and highlight the key advances in their mechanisms of action at the molecular level.

In response to this report, SENS Foundation CSO Dr. Aubrey de Grey has said that «If this is as good as it looks, I think it could be a real game - changer», and Dr. O'Connor and his team at the SENS Foundation RC are considering testing a construct based on Teitell's methods in a system that the RC has already generated and used for testing of allotopic expression of cytochrome B.

Rudolf will receive more than $ 900,000 over five years to support his research on discovering new drugs from natural resources using cytochrome P450 enzymes.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

And so, if it's not working correctly, and there are several other polymorphisms that impact this as well, uhm — on the first page of the report, some of the Cytochrome P450, uh — enzymes.

Read Phylogenetic analysis of smelts (Osmeridae) based on the variation of cytochrome b gene, Russian Journal of Genetics on DeepDyve, the largest online fdating com review.