However, Anson et al. displayed increased levels of IGF - 1 in mice on alternate - day fasting diets with maintained body weight compared to controls, in contrast to mice
on daily calorie restriction who showed decreases in bodyweight and decreased IGF - 1 (17).
These mice managed to maintain constant body weight but, interestingly, still acquired some of the health benefits as rats
on daily calorie restriction.
Anson et al. showed that mice on alternate - day fasting regimen who consume the same amount of food in a 48 - hour period as mice fed ad libitum, decreased glucose and insulin concentrations to a similar degree as did mice
on daily calorie restriction despite maintained energy intake and body weight (17).
In line with animal studies
on daily calorie restriction, alternate - day calorie restriction has shown beneficial effects in neuronal disorders such as stroke, epilepsy and neurodegenerative disorders, including Alzheimer's, Parkinson's and Huntington's disease.
Most of the studies
on daily calorie restriction used DXA or MRI to measure body composition, which are considered some of the most accurate tools.
A review in 2011 compared 5 published (and 2 unpublished) intermittent calorie restriction studies to 11 of
those on daily calorie restriction.
The longest trials
on daily calorie restriction were 24 weeks, whereas the longest trials on intermittent calorie restriction were only 12 weeks.
Not exact matches
Dr Davis also notes: «It might be due to the lack of exorphins, reduction of the insulin - glucose cycle that triggers hunger, or some other factor, but elimination of wheat reduces
daily calorie intake by 350 to 400
calories — with no further
restrictions on calories, fats, carbohydrates, or portion sizes.
Yet CR advocates put themselves through 30 - 50 %
calorie restriction on a
daily basis as a way of life in the hopes of extending life span or health.
And because there are low
calorie and low carb protein shakes, there is no need to worry about exceeding your
daily calorie restrictions or to fear gaining weight if you're
on a diet.
Furthermore, mice
on alternate - day fasting diets showed greater resistance to excitotoxic injury than mice
on daily, controlled
calorie restriction (17).
Doctors and others may suggest that doing an hour
on the treadmill, elliptical or stationary bike
daily with some
calorie restriction on your food will get you there.