Sentences with phrase «on different factors including»

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Note: Yelp's search results are based on an algorithm that is designed to provide the best results based on a number of different factors including review text, ratings, and number of reviews.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

In our statistical analysis, we include all of the confounding factors discussed above, and control for demographic and regional differences in order to tease out the effects of different factors on whether Canadians support, oppose, or have no opinion about an FTA with China.

The after - tax discount rate for an individual could be very different from another depending on multiple factors, including the sources and levels of income.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange CommFactors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

It may be an arrangement that factors out different aspects of the school's common life to the reign of each model of excellent schooling: the research university model may reign for faculty, for example, or for faculty in certain fields (say, church history, or biblical studies) but not in others (say, practical theology), while paideia reigns as the model for students, or only for students with a declared vocation to ordained ministry (so that other students aspiring to graduate school are free to attempt to meet standards set by the research university model); or research university values may be celebrated in relation to the school's official «academic» program, including both classroom expectations and the selection and rewarding of faculty, while the school's extracurricular life is shaped by commitments coming from the model provided by paideia so that, for example, common worship is made central to their common life and a high premium is placed on the school being a residential community.

The 27th World Health Assembly in 1974 noted the general decline in breastfeeding related to different factors including the production of manufactured breast - milk substitutes and urged Member countries to review sales promotion activities on baby foods and to introduce appropriate remedial measures, including advertisement codes and legislation where necessary.

As the researchers looked at area - level data, they note their findings may not apply to individuals living in those areas as they may have different individual - level cardiovascular risk factors, length of residence in the particular area, time activity patterns including commuting to work, and the direction in which the windows on their residence face varies.

We demonstrated the technique on 20 different biological processes spanning four orders of magnitude in space and time, including the binding kinetics of single Sox2 transcription factor molecules, 3D superresolution photoactivated localization microscopy of nuclear lamins, dynamic organelle rearrangements and 3D tracking of microtubule plus ends during mitosis, neutrophil motility in a collagen mesh, and subcellular protein localization and dynamics during embryogenesis in Caenorhabditis elegans and Drosophila melanogaster.

To examine whether physical workload is a possible risk factor for RA, information on different types of self - reported exposure was analysed from a population of 3,680 RA patients and 5,935 matched controls included in the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA).

Kamiel and Wei Yang and Yaolin Lin, associate professors at the Wuhan University of Technology in China developed a holistic and integrated model which considered the building enclosure, the mechanical systems, the external environment, the proportion of window opening and the shading factor based on data collected from 270 households including single and multiple units, as well as different heating methods.

These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.

My research interests include investigating the role of RNA degradation in Drosophila development, investigating the impact of wounding in the Drosophila embryonic central nervous system, and investigating the effect of protein degradation on the activity of different transcription factors in neuronal fate decisions during nervous system development in Drosophila.

Different factors, including the free radicals that are a byproduct of oxygen metabolism, result in Top1ccs becoming trapped on DNA and accumulating in cells.

This includes predictive factors, validation of diagnosis specific tools for functional assessment as well as the impact of different surgical techniques and type of chemotherapy used on the incidence of chronic pain after surgery and adjunctive cancer treatment.

Depending on a variety of factors (including climate, brands of ingredients etc) this batter can do different things.

There are different theories for why SAD may occur, including genetic factors, poor regulation of serotonin — a neurotransmitter that has been found to be lower in the winter in individuals with SAD — and higher melatonin levels, which in combination with low serotonin, wreaks havoc on the natural circadian rhythm and the sleep - wake cycle.

The amount of total fat and omega - 3 fatty acids found in different species of fish and shellfish can vary depending on a number of factors including the diet of each species, the season and location of the catch, the age and physiological status of the individual organism, and reproductive cycles.

The brain is constantly bombarded by many different factors including age and stress, and these take their toll on the brain over time.

The final results depend on many different factors, including your eating habits before the Egg Fast that you will quite likely return to.

While everyone is different and has different needs based on many different factors including age, body type, blood type and cultural background, for most people, a balanced diet consists of about 50 % veggies, 25 % non-processed starches (whole grains, starchy vegetables such as potatoes, yams or corn), and 25 % protein.

So of course, your suitcase will look a little different than mine depending on a few factors, including how long you're going to be traveling.

The question of what size is right for different spaces depends on several factors, including your personal preferences to how big an accent wall is and how many other decorations you're planning on using.

When it comes to diet and health, though, every «body» is different and each of us need different nutrients to thrive depending on a number of different lifestyle factors including: ancestry, blood type, and activity level.

A list of the top blogs in the Dating category based on 20 + different factors including RSS membership, Number of incoming links, social media, monthly visits.

Last week we spoke to three sociologists who debunked some of the myths surrounding college dating — namely that hook - up culture is more of a subculture A list of the top blogs in the Dating category based on 20 + different factors including RSS membership, Number of incoming links, social media, monthly visits.

ASSESSING THE FACTORS Organisers liability insurance is offered on different levels according to a variety of factors, including risk, distance, duration, number of trips per year, and other fFACTORS Organisers liability insurance is offered on different levels according to a variety of factors, including risk, distance, duration, number of trips per year, and other ffactors, including risk, distance, duration, number of trips per year, and other factorsfactors.

Included in the PowerPoint: Macroeconomic Objectives (AS Level) a) Aggregate Demand (AD) and Aggregate Supply (AS) analysis - the shape and determinants of AD and AS curves; AD = C+I+G + (X-M)- the distinction between a movement along and a shift in AD and AS - the interaction of AD and AS and the determination of the level of output, prices and employment b) Inflation - the definition of inflation; degrees of inflation and the measurement of inflation; deflation and disinflation - the distinction between money values and real data - the cause of inflation (cost - push and demand - pull inflation)- the consequences of inflation c) Balance of payments - the components of the balance of payments accounts (using the IMF / OECD definition): current account; capital and financial account; balancing item - meaning of balance of payments equilibrium and disequilibrium - causes of balance of payments disequilibrium in each component of the accounts - consequences of balance of payments disequilibrium on domestic and external economy d) Exchange rates - definitions and measurement of exchange rates - nominal, real, trade - weighted exchange rates - the determination of exchange rates - floating, fixed, managed float - the factors underlying changes in exchange rates - the effects of changing exchange rates on the domestic and external economy using AD, Marshall - Lerner and J curve analysis - depreciation / appreciation - devaluation / revaluation e) The Terms of Trade - the measurement of the terms of trade - causes of the changes in the terms of trade - the impact of changes in the terms of trade f) Principles of Absolute and comparative advantage - the distinction between absolute and comparative advantage - free trade area, customs union, monetary union, full economic union - trade creation and trade diversion - the benefits of free trade, including the trading possibility curve g) Protectionism - the meaning of protectionism in the context of international trade - different methods of protection and their impact, for example, tariffs, import duties and quotas, export subsidies, embargoes, voluntary export restraints (VERs) and excessive administrative burdens («red tape»)- the arguments in favor of protectionism This PowerPoint is best used when using worksheets and activities to help reinforce the ideas talked about.

Yet, with changing learner demographics (includes Gen Y in significant numbers), these organizations need to factor for learning strategies that are different and are deployable on devices of the learners» choice (tablets and smartphones).

The DCPS funding formula does differentiate public funding based on the number of students at each grade level and in different special needs categories, including special education, English language learners, and those «at risk» for academic failure.38 DCPS would not disclose how or if it factors in parental donations when determining school budgets or allocations.39 However, it did report not having a policy to equitably redistribute parent donations or to prohibit these additional dollars from being put toward staffing.40

Connecticut has a whopping 12 different factors in its school rating plan, including academic achievement and growth on tests (52 percent) and graduation rates (15 percent), chronic absenteeism (7.4 percent) and physical fitness and access to arts classes (3.4 percent each).

This is because it depends on a variety of other factors, including the individual risk, and the different insurers we use have different views on this.»

Products were entered in 16 different categories, and awards were given to the most innovative and cutting - edge automotive aftermarket products based on a variety of factors that included quality, marketability, innovation, technology, consumer appeal and more.

Front dual - stage air bags that deploy at different rates or not at all, depending on factors including the force of a crash, the driver's seat position and whether front occupants are wearing seat belts.

However, unlike the regular book world where massive chains are teetering on the brink thanks to many factors — including online sales — Steinberger feels comic shops and the digital sales of comics have a different, less competitive connection.

They base ordering decisions on lots of different factors, such as the publisher's official print order, but in more recent years with Nielsen bringing in BookScan which all the big players use, they have more information about sales track records, including pre-orders.

Which is best for you depends on several different factors, including your age, income and financial goals.

Your actual interest rate may be different than the student loan interest rates in these examples and will be based on term of loan, your financial history, and other factors, including your cosigner's (if any) financial history.

Depending on many different factors, including the size of the check, the point of origin and your account history, the bank may take as long as a week to make the full amount available.

The asset mix of an insurance company's investment portfolio varies over time based on different influences, including both macroeconomic and industry - specific factors.

Your actual student loan interest rate may be different than the rates in these examples and will be based on your credit history, which repayment option you choose and other factors, including your cosigner's (if any) credit history.

Well, everyone's financial situation is different, so the answer will depend on a variety of factors including your age, income, expenses, etc., but there are a few things every person should probably be doing when a full - on crash begins to seem inevitable (even if it isn't).

Your credit score is based on several different factors including: how timely you pay your bills, how much you've borrowed, how long you've had credit, the types of credit accounts you have, and whether you've recently applied for credit.

In fact, credit scores are specifically based on several different factors, including the following: 1.

Federal loans offered through the Department of Education have fixed interest rates, while private student loan lenders offer loans at different rates depending on many factors including your credit score, income, and employment history.

There are more than 100 REIT mutual funds (including different share classes), thus choosing which one to invest depends on many factors on the investor's objective, risk tolerance, return expectation, etc..

Your actual interest rate may be different than the rates in these examples and will be based on term of loan, your financial history and other factors, including your cosigner's (if any) financial history.

The after - tax discount rate for one individual could be very different from that of another individual depending on multiple factors, including the sources and levels of income.

Forecasting what may most likely happen with these factors over time (given the assumed fluctuations in the markets - which you can control every year by using different rates of return on every investment for every year - including negative rates of return, and being able to change your income goal every year) is much more important to model, than a one - dimensional probability number, to an actual investor's life.