Massachusetts About Blog In The Pipeline blog features Derek's excellent commentary
on drug discovery and the pharma industry.
Cambridge MA About Blog A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact
on drug discovery.
Massachusetts About Blog In The Pipeline blog features Derek's excellent commentary
on drug discovery and the pharma industry.
The Company's second program is centered
on drug discovery using human induced pluripotent stem cells.
It seems reasonable to expect a huge effect
on drug discovery and other practical areas.
The new San Francisco Bay Area facility will focus
on drug discovery and early drug development for diseases like neurodegeneration and cancer.
As Zambrowicz at Lexicon Genetics says, «New technologies could have a huge impact
on the drug discovery process.»
In addition to authoritative insights and collections of reviews, features, and News Focus articles in Science, Science's Signal Transduction Knowledge Environment and the Science of Aging Knowledge Environment will offer special content
on drug discovery.
Although the pharmaceutical industry, like the rest of the business world, has suffered a slowdown, the market research company Frost and Sullivan still expects spending
on drug discovery to expand from US$ 19.6 billion in 2002 to US$ 25.6 billion by 2006, an annual growth rate of about 6 %.
She says she spent far less time
on drug discovery and far more time sorting out the changes and persuading committees to keep her programs going.
Lowe, a medical chemist by profession, provides daily commentary
on drug discoveries, the pharmaceutical industry, and relevant research and news, especially in chemistry.
Not exact matches
In January 2017, SiteOne announced the closing of a research and development agreement with Amgen, a collaboration focused
on combining SiteOne's experienced
drug discovery team and portfolio of novel Naᵥ1.7 inhibitors with Amgen's neuroscience capabilities.
Kevin Lustig, founder of Assay Depot Lustig founded Assay Depot
on the belief that empowering scientists will improve innovation and expedite
drug discovery for the world's rarest diseases.
CalciMedica is a privately - held, clinical stage biopharmaceutical company focused
on CRAC channel
drug discovery and development for the treatment of acute and chronic inflammatory diseases.
Located in South San Francisco, Calif., and funded by leading investors, including The Column Group (TCG), Kleiner Perkins (KP), Topspin Partners, GV and Celgene Corporation, we have assembled a leadership team and advisory group with a proven track record of success and team of scientists with substantial knowledge and expertise in
drug discovery and translational areas essential to execute
on this approach.
Located in South San Francisco, Calif., and funded by leading investors, including The Column Group (TCG), Kleiner Perkins (KP), Topspin Partners, GV (formerly Google Ventures) and Celgene Corporation, FLX Bio has assembled a leadership team and advisory group with a proven track record of success and team of scientists with substantial knowledge and expertise in
drug discovery and translational areas essential to execute
on this approach.
SOUTH SAN FRANCISCO, Calif. — February 5, 2018 — FLX Bio, Inc., a biopharmaceutical company focused
on the
discovery and development of oral small molecule
drugs to activate the immune system against cancer, today announced the appointment of senior pharmaceutical research and development executive Michael F. Giordano, M.D., to its Board of Directors.
It now requires,
on average, over a billion dollars of investment and upwards of a decade to move a new
drug from
discovery to commercialization.
MaRS Innovation (MI) and the Centre for
Drug Research and Development (CDRD) are pleased to announce that they have entered into an agreement to collaborate
on projects of mutual interest with a goal to advance and commercialize early - stage health - related
discoveries.
Looking at sixty - seven recent
drug discovery projects based
on preclinical cancer biology research, they found that in more than 75 percent of cases the published data did not match up with their in - house attempts to replicate.
Prior to the enactment of these laws, it was primarily mothers
on drugs or with mental problems (including extreme fear of
discovery) who abandoned babies.
Get your name
on these... 3,4, or 5 first author
drug discovery type papers and your name
on a few patents and you'd be marketable.
Chemical biology and
drug discovery usually depend
on screens of cells in lab dishes, for example.
Watson thought the center would focus
on cancer
drug discovery.
The tour officially began that evening with a team exercise put
on by Dr. David Alker, manager of the
Discovery Staffing Group at Pfizer, who took us through a simulation of the
drug discovery process.
So, to work
on the
discovery of new
drugs can be exciting, but it is very frustrating, too.
The
drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author
on the scientific paper reporting the
discovery.
The programme also includes a day - long symposium consisting of talks
on a spectrum of career perspectives, from project management to
drug discovery to careers in the development of future energy sources.
Richard Hargreaves, executive director of imaging at Merck Research Laboratories, says, «Nuclear imaging using radiotracers gives the opportunity to put your arms around proof - of - concept very early in a
drug discovery and development program by focusing the selection of doses to study
on those proven to deliver enough
drug to the target therapeutic sites.»
I am picking up knowledge about
drug discovery on the job, both through structured workshops and by interacting with more experienced colleagues.
Those moves represent a shift by Pfizer toward a more specialized approach to
drug discovery and follow another trend in the industry: streamlining R&D by focusing
on specific disease areas — a strategy biotechs already employ albeit
on a smaller scale.
Although the small company I worked for did not conduct animal testing
on site, my work in
drug discovery and providing analytical support to pharmacology directly linked me to the pharmacokinetic and toxicology screening tests.
Whereas most conventional scientists focus
on a single system or disease, Butte earned tenure recently with a dossier of advances in diabetes, obesity, and transplant rejection, and the
discovery of new
drugs for lung cancer and other diseases.
This can guide
drug discovery by letting you simulate the effect of a
drug on the circuit.
Respondents in this year's survey pointed to five main causes of the field's less than favorable reputation:
drug and product recalls such as the withdrawal of Avandia; safety issues such as the
discovery of problems with raw material from China used in medical products; scandals, including evidence that pharmaceutical companies have failed to release data from trials whose results cast doubts
on their
drugs» safety and efficacy; lawsuits brought against companies that failed to warn patients of problems with their products; and ethical issues such as kickbacks for physicians promoting specific medications.
David Rees, senior vice president of medicinal chemistry at Astex Therapeutics, a fragment - based
drug discovery specialist based in Cambridge, keeps a keen eye
on the recruitment market in the city.
Affinium, a University of Toronto spin - off, has been in the
drug discovery business for 4 years and focuses
on the development of novel antibiotics.
Nevertheless, Canadian job opportunities in
drug discovery are
on the rise, Harack declares, as the local biotechnology industry enters its «early teen» phase, growing from early stage R&D to development and commercialization.
The researchers»
discovery of a control switch that acts
on the UPR pathway, published March 25 in the online edition of EMBO Reports, opens new
drug development avenues for treating a wide variety of diseases by modulating the UPR pathway to prevent excessive cell death.
Working
on the premise that scientific research is the foundation of any technology industry, Hancock and others at UBC are writing a business proposal for an integrative centre for
drug research, with an objective of developing intellectual property in
drug discovery, providing training for
drug discovery researchers, and developing new technologies.
For the purpose of FOP
drug discovery, scientists have normally focused
on molecules associated with BMP signaling.
Rao says that if he had to choose three scientists — the limit for the Nobel — then he would pick either Yu Yagang, Tu Youyou, and Zhong Yurong for the
discovery of artemisinin; or Tu Youyou, Luo Zeyuan, and Li Ying for the early work
on artemisinin that led to the
drug therapy.
Organic synthesis is a scientific discipline central to the
drug discovery process that is focused
on building new carbon - based molecules that can affect biology — for example, targeting and destroying cancer cells.
The
discovery now provides a potential new target for
drug developers to home in
on.
At CeMM, a number of key
discoveries on new applications for approved
drugs have already been made with the CLOUD.
Meanwhile, Maura Furey of the National Institute of Mental Health and her colleagues are following up
on the
discovery that intravenous delivery of scopolamine, a motion - sickness
drug, relieves depressive symptoms in people within days.
The pharmaceutical industry is research and development driven, given that company growth and viability are dependent
on the
discovery of new
drug molecules.
As industry giants lose patent rights
on big - money
drugs such as Lipitor and Plavix, they are looking to offset lost revenues by cutting costs and lowering exposure to the risks and expenses of
drug discovery and development.
Science Careers spoke to scientists from several companies, big and small, seeking tips
on where and how to seek scientific jobs in
drug discovery and development.
Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new
drug discovery technique, which allows them to find — relatively quickly and cheaply — antibodies that have a desired effect
on cells.