Sentences with phrase «on drug resistance»

A team from the University of Melbourne has reached the finals of the «Oscars of science» — the Australian Museum's annual science award, the Eureka Prize — for its work on drug resistance in malaria parasites.

A team from the University of Melbourne has been honoured with an «Oscar of science» — the Australian Museum's annual science award, the Eureka Prize — for its work on drug resistance in malaria parasites.

Farrar is now heading the Oxford University Clinical Research Unit in Ho Chi Minh City, Vietnam, where he has done research on drug resistance in tuberculosis and other diseases.

The new analysis includes data on drug resistance in 39 countries, and profiles of antibiotic use in 69 countries, and is the first time such data has been combined.

... One way to cut down on drug resistance transfer is to stop prescribing antibiotics almost...

Not exact matches

Digital technology, resistance to drugs, food security and water consumption are all on the agenda.

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Another board on which members of the Kolaj family sit is the Drug Abuse Resistance Education program.

The drug - like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel, lead author on the scientific paper reporting the discovery.

So far there's no approved drug on the market that reverses cancer chemotherapy resistance caused by P - glycoprotein, or P - gp for short, said Vogel, a biochemistry professor at SMU.

The conventional idea is that susceptible bugs perish, leaving behind a few individuals whose drug resistance is passed on as they multiply.

«For years, researchers have focused on delivering more chemotherapy drugs into cancer cells using nanoparticles, without targeting the root of drug resistance,» He said.

Combined, these two pieces of RNA look like RNase P's normal target, so the enzyme grabs on and slices the drug resistance RNA in two.

GTC recognized the need to demonstrate on its own the potential for the technology and, in the late 1990s, began a clinical trial of human antithrombin for patients undergoing bypass surgery who develop resistance to the anticoagulant drug heparin.

Pressure to ban the practice has fallen on the US Food and Drug Administration (FDA) following a court ruling and the publication of research showing how a strain of bacteria jumped from humans to farm animals and back again, picking up antibiotic resistance on the way.

Overuse of drugs on human patients and farm animals has helped fuel the rise of such drug resistance.

Globalization, changing climate, and the threat of drug resistance have conspired to set the stage for that perfect microbial storm: a situation in which an emerging pathogen — another HIV or smallpox, perhaps — might burst on the scene and kill millions before we can respond.

Former mainstay drugs (chloroquine and sulfadoxine — pyrimethamine) also experienced their first resistance challenges in western Cambodia before spreading to other parts of Asia and on to Africa, where the parasites killed millions.

A recent study from a U.K. commission on antimicrobial resistance estimated that by 2050, antibiotic - resistant bacterial infections will kill 10 million people per year, if no new drugs are developed.

Dr David Aanensen, head of the Centre for Genomic Pathogen Surveillance and joint lead author on the paper said: «Drug resistance is a growing problem both in Europe and across the world and doctors need fast and accurate information to stop epidemics.

Nyunt, a malariologist at the University of Maryland School of Medicine (UMD) in Baltimore, is visiting Sa - ka - pin to assess the extent of one of the biggest problems facing an ambitious campaign to wipe out malaria from the Mekong region (see feature story on How drug resistance triggers war to wipe out malaria in the Mekong region): the number of people infected with malaria who have no symptoms.

«It is only with more knowledge on antibiotic resistance dissemination — from the environment to pathogens in the clinic and leading to antibiotic treatment failure rates — that we will be able to produce more sustainable antibiotic drugs,» Nesme says.

On the scientific agenda are identifying molecular markers for resistance, which would simplify testing; accelerating the development of alternative drugs; and studying the effectiveness of mass screening and treatment to eliminate malaria in the areas where resistance occurs.

The technique allows a comprehensive description of the composition of MGIs, and will reveal information on the strength of an infection and the development of drug - resistance, which can inform disease control interventions.

«Prevent antibiotic resistances from spreading: Rapid test helps administering the «correct» drug: Scientists develop new rapid test that gives information on antibiotic resistance in just three hours.»

A comparison of the dopamine receptors in the coke caterpillar with those of the silkworm, which doesn't feed on cocaine plants, revealed that E. noyesi has evolved resistance to the effects of the drug.

«An industry scientist, Bill Sheridan of BioCryst Pharmaceuticals Inc., which is headquartered in Durham, North Carolina, cautioned that new flu drugs must be tested on wild strains to look for resistance, which is one way of enhancing a virus,» Kaiser wrote.

We found that the genetic background had a major influence on whether or not weaker mutations would confer drug resistance, and in these cases many different cells adapted in a wave.

It would receive $ 8.7 million to extend its review of antibacterial drugs and oversight of antibiotics in livestock as part of the Combating Antibiotic - Resistant Bacteria (CARB) initiative, a national strategy that has prompted Congress to nearly double overall spending on antibiotic resistance across several agencies, to $ 774 million in 2016.

Scientists at the Wellcome Trust Sanger Institute and the Institute for Research on Cancer and Ageing of Nice in France, show that high genetic diversity can prime new mutations that cause drug resistance.

In one experiment this year, a team led by another CRISPR pioneer, Feng Zhang of the Broad Institute in Cambridge, Massachusetts, targeted the 20,000 or so known human genes, turning them on one by one in groups of cells to identify those involved in resistance to a melanoma drug.

They found evidence that the drug turns on the gene that produces the protein «FOXO,» a master regulator of stress resistance in many organisms that is often central in longevity studies.

Based on their gene - drug interaction map, the researchers predicted that mutations in two genes, called ARID1A and GPBP1, could contribute to ovarian cancer's ability to develop resistance to this class of drugs.

In future, Bandyopadhyay says, better understanding how chemotherapy agents impact specific biological pathways should allow drug trials to focus on patients who are more likely to respond to the drugs being tested and enable clinicians to identify targeted or combination therapies for patients with a genetic predisposition to resistance.

The work builds on the success of the Lincoln team's pioneering research to tackle antimicrobial resistance over the past 22 months to turn teixobactin into a viable drug.

«The over-prescribing of anti-malarials puts evolutionary pressure on the malaria parasite that risks hastening its resistance to artemisinin - based combination therapy — the frontline drugs used to treat malaria in Africa,» Stoler said.

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

Plus, the sustained antibiotic onslaught supposedly ensures that any hardier, partially drug - resistant bacteria also succumb, and thus don't pass on «stepping - stone» genes leading to full - blown resistance.

When they focused on genes involved in drug resistance, the group found that C. krusei differs from C. albicans; many of the sites that are often mutated in the target of azole drugs in resistant C. albicans are not mutated in C. krusei.

A study published on June 25th in PLOS Pathogens reports a new way to circumvent drug resistance and lower the curative dose by delivering existing drugs directly into the parasite, a high - tech approach with potential applications to other infectious diseases.

This webinar will focus on how rewiring of signaling pathways in response to drug treatment contributes to resistance and how this knowledge can be leveraged to develop more effective treatment strategies.

«We on the outside of the US are gravely concerned about the drug resistance emerging in the US,» said Peter Davies, a TB researcher at Sefton General Hospital, Liverpool.

They show that this new formulation reduces the minimal curative dose in a disease model, based on infections in mice, by 100-fold and, most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.

This special issue of Science focuses on diverse areas where public health can be improved by making better use of the resources we have in our grasp, ranging from tailoring engineering projects to meet the needs of material - and infrastructure - limited regions, to building a surveillance network for the detection of drug resistance, to empowering women.

Building on research recently published in Cell Reports, the researchers identified new mutations that appeared to be driving the strong drug resistance exhibited by these tumors.

Epidemiologists worry that the combination of HIV - burdened immune systems and total drug resistance could put TB on the fast track to causing an uncontrollable epidemic.

«Our results also suggest that most of the mutations leading to influenza drug resistance are on the wane, so that recent efforts in controlling drug use are paying off, but we should remain vigilant,» commented Stéphane Aris - Brosou.

Drugs that target this machinery would not kill the microbes, just stop them from hanging on, so they should be less likely to provoke resistance, says David Brown of charity Antibiotic Research UK, who was not involved in the study.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

We must strengthen infection control measures, focus on households, health centres, and communities to prevent tuberculosis spreading from person to person, and develop more effective diagnostic tests to rapidly and accurately detect drug resistance.»