Sentences with phrase «on drugs designed»

Professor Davis, author of the popular Penguin paperback The Compatibility Gene, concludes: «The practical application of this basic research comes from bouncing around our ideas with scientists working on drug design.

Not exact matches

In December, Tehrani signed a deal with GlaxoSmithKline that will allow the pharmaceutical giant to test at least four of its drug candidates on a Zymeworks - designed platform, which combines a computer simulation with a way of engineering protein molecules and allows products to be refined before they move to expensive clinical trials.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Rõivas, the former Prime Minister, says Estonia is working on developing «precision medicine» that would tap into the genome data of its 1.3 million citizens in order to better diagnose illnesses, treat people, and design personalized drugs.

That design can hit Americans with high deductibles who rely on high - cost drugs especially hard.

Investigators have repeatedly touted the drug as a potential lynchpin in immuno - oncology, focusing on an enzyme that suppresses the immune cells Opdivo and a whole new class of PD - 1 / L1 checkpoints are designed to unleash in an attack on cancer cells.

That cash doesn't include the money PhRMA's spending on the ongoing «Go Boldly» campaign, a series of TV, print and radio ads designed to polish the drug industry's image by reminding the public that drug companies do world - class research that brings disease cures to market to save lives.

Write, telegraph, phone, and make personal calls on legislators and governmental officials (national, state, and local) encouraging them to support legislation designed to provide humane treatment for alcoholics, drug addicts, the mentally ill, and the mentally retarded.

Baseball is on drugs, and the human body wasn't designed to throw baseballs.

In a 1992 article in The North American Review entitled «The Corruption of Nobility: The Rise & Fall of Thoroughbred Racing in America,» Ferraro penned a stinging rebuke against drug abuse on the backstretch, saying, «In general, treatments designed to repair a horse's injuries and to alleviate its suffering are now often used to get the animal out onto the track to compete — to force the animal, like some punch - drunk fighter, to make just one more round.

DRUGS AND ALCOHOL: just say no is a beautifully illustrated handout designed specifically for fathers, to help them communicate effectively with their children on the topics of drugs and alcDRUGS AND ALCOHOL: just say no is a beautifully illustrated handout designed specifically for fathers, to help them communicate effectively with their children on the topics of drugs and alcdrugs and alcohol.

She has received more than 40 grants from the National Institute of Mental Health and the National Institute on Drug Abuse to design prevention programs for children and families at high risk for HIV, mental health problems, suicide, and substance abuse.

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I tried everything, and eventually settled on taking the maximum dose of Domperidone, a drug that was actually designed for stomach issues, but doubles as a galactagogue.

The psychoactive substances bill sought to crack down on legal highs — especially the new generation of drugs that are designed to mimic the effects of traditional illicit substances such as cannabis and ecstasy — which the Home Office says caused 129 deaths in 2015.

Officers in all but five police departments in Erie County carry naloxone, known by the brand name Narcan, a rescue nasal spray designed to revive users who overdose on opioid drugs.

HARLEM — Stores that sell synthetic marijuana could lose their tobacco licenses or be shuttered as nuisances under proposed legislation designed to crackdown on sale of the drug, City Council Speaker Melissa Mark - Viverito said Tuesday.

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.

«This well - designed set of experiments shows that chronic THC pretreatment appears to restore a significant level of diminished cognitive performance in older mice, while corroborating the opposite effect among young mice,» wrote Susan Weiss, director of the Division of Extramural Research at the National Institute on Drug Abuse, who was not involved in the study, in an e-mail.

And in several large - scale pharmaceutical trials, drugs specifically designed to elevate HDL had no effect on heart disease risk.

Two other multi-national trials randomized 27,438 patients to either bococizumab or placebo and were designed to evaluate the impact of the drug on cardiovascular outcomes, including nonfatal heart attack and stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death.

Bowen joined the National Institute of Diabetes and Digestive and Kidney Diseases in 1991 as chief of the Unit on Receptor Biochemistry and Pharmacology, in the Drug Design and Synthesis Section of the Laboratory of Medicinal Chemistry.

Questions were specifically designed to elicit information on drug dealing activities and organisation of crime and, as the study progressed, a number of key issues started to emerge.

The pioneering scientist / entrepreneur on biology's next leap: digitally designed life - forms that could produce novel drugs, renewable fuels, and plentiful food for tomorrow's world.

«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.

Merely producing pharmaceutical drugs that are me - too copies of what's already on offer (or titanium golf clubs designed to provide some slight edge on the greens) is not exactly what made America great.

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

The team's results uncover a previously unknown, complex genomic landscape of this cancer, which can be used to design new personalized drug regimens for SS patients based on their unique genetic makeup.

The researchers targeted mTOR with an experimental drug based on a prototype first designed by Shokat, a chemist and an expert in designing molecules to target this type of protein, called a kinase.

The experiments are designed to show whether the drugs have side effects that would be dangerous on the battlefield, such as drowsiness.

Designed by researchers at Sangamo Biosciences, the drug uses a natural protein that turns on the patient's own gene for helping nerve growth.

«On the other hand the US Food and Drug Administration has taken the more conservative approach which recognises that SQUIRE was designed for all - comers without prior selection, and this subgroup analysis is insufficient evidence to conclude that patients with EGFR negative tumours are not candidates.»

Working with the pharma and biotech industries, Poirier focuses on both performing the genetic tests in his laboratory and designing the clinical drug trials.

She says that these findings also have implications for designing treatments for Parkinson's, noting that some drugs currently under development are focused on getting rid of larger fibrils that make up Lewy bodies.

For treatment, that knowledge could make a huge impact: not only should researchers be better about testing potential migraine drugs on men and women separately, Maleki says, but they may be able to design new treatments based on these brain differences — giving both sexes a better chance at relief.

«Maybe we can design a drug that would specifically target this [novel] chemistry,» says Cross, who notes that the virus's reliance on M2 might make mutating against such a specialized drug difficult.

Scientists and physicians have tried countless methods to treat the nightmares, anxiety, and flashbacks of posttraumatic stress disorder (PTSD) in soldiers, from talk therapy to drugs designed to press the «delete» button on specific memories.

«This is a major breakthrough for genetics studies on the virus and for designing ways to screen for effective drugs,» Rice says.

This research on these protein clusters, or aggregates as scientists call them, could help guide design of new anticancer drugs.

Senior CRAs can become project managers, responsible for the design and overall management of a trial, and then on to be programme managers or directors in charge of multiple drug trials or of a therapeutic area.

Gerry Potter and Ray McCague of the Institute of Cancer Research in Surrey based their design strategy on tamoxifen, a drug widely used for treating breast cancer.

The researchers allowed rats to self - administer meth using a paradigm designed to examine individual differences in the rats» drug - taking behavior, then tested the effects of oxytocin on their motivation to acquire the drug.

While the United States focuses on figuring out how to keep drugs and other chemicals out of the nation's waterways, the European Union's approach could be called «benign by design.»

And earlier this year, the lobbying group PhRMA launched a multimillion dollar ad campaign designed to repair its image by reminding the public that the industry aims to discover new drugs, not just raise prices on old ones.

As the pace of drug approvals accelerates and the U.S. Food and Drug Administration (FDA) faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their drug approvals accelerates and the U.S. Food and Drug Administration (FDA) faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their Drug Administration (FDA) faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their use.

«You can use all the «omics» — proteomics and metabonomics and so on — to help you discover why some people don't respond to certain treatments, but you're still going to need people to design and make the drugs to treat them,» he says.

Researchers investigating the toxicity of particles designed to ferry drugs inside the body have found that carriers with a positive charge on their surface appear to cause damage if they reach the brain.

A race is now on to commercialize quantum computers, making them available to companies that want to solve problems particularly suited to quantum machines, such as designing new materials or speeding up the search for new drugs.

By explaining how the drug operates, their research might allow others to design new antibiotics that could in fact be used to treat tuberculosis patients — and might even work on other bugs.

Accompanying this progress has been a growing reliance of experimental researchers on computer - aided drug design (CADD).