Sentences with phrase «on early clinical»

The latest comes from Dr. Robert Krikorian and his team of colleagues from the University of Cincinnati Academic Health Center who conducted two human studies to follow up on earlier clinical trials.

Not exact matches

When it comes to conducting clinical trials on a cross-border level, though, it is still early days and there are many hurdles.

Following a devastating clinical trial setback earlier this month for its lead experimental product, a cannabidiol gel, in epilepsy, the firm reported another trial failure on Monday for the product in treating knee pain due to osteoarthritis.

Shares of cancer - focused biotech Clovis Oncology soared nearly 50 % in early Monday trading on the strength of clinical trial results for its ovarian cancer treatment Rubraca.

Earlier this year Merck halted trials on its once - promising Alzheimer's drug after an independent panel of ruled there was «virtually no chance of finding a positive clinical effect.»

An early, outsourced clinical research study with real patients was encouraging, but there are many potential pitfalls yet to come, said University of North Carolina diabetes researcher Dr. John Buse, who was briefed by Google on the lens last week.

Specifically, the process allows early approval of a drug to treat a serious or life - threatening disease based on clinical data.

«Establish the needs of each partner early on, practice working towards meeting those needs, and give feedback about which needs are still being unmet,» clinical psychology PhD student and long - distance relationship researcher Emma Dargie told Business Insider.

Pharmaceuticals: Reflects Canada's existing regimes, systems and laws on: patent linkage; protection for clinical trial data; and early working exceptions.

«Recent research on humans published in the American Journal of Clinical Nutrition earlier this year indicates that drinking diet beverages does not cause people to overeat or to increase their intake of sweet foods and beverages.

Read on for technical insights and market information on key usage applications and opportunities for these dairy ingredients in three growing categories that are highly dependent on high - quality protein sources: sports nutrition, infant and early child nutrition and clinical nutrition.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

We can be ruthless on the counter too but we really need to be more clinical in front of goal, no matter the style we impose on the day, even if its smash and grab, we need to put our chances away and kill teams off early

Arsenal could have been more clinical and could have killed Hull off earlier than they did, but 4 - 1 wasn't a harsh reflection on the hosts.

On being clinical in front of goal «We said today we had to come out with energy and get that early goal because Huddersfield have had a great start to the season, they are an energetic team themselves and we did that perfectly.

Low family income during the early childhood has been linked to comparatively less secure attachment, 4 higher levels of negative moods and inattention, 5 as well as lower levels of prosocial behaviour in children.2 The link between low family income and young children's problem behaviour has been replicated across several datasets with different outcome measures, including parental reports of externalizing and internalizing behaviours,1 - 3, 7 -9,11-12 teacher reports of preschool behavioural problems, 10 and assessments of children based on clinical diagnostic interviews.7

The PhD course focuses on various aspects of human (donor) milk, with as main study a randomized clinical trial towards the effects of human donor milk in very low birth weight infants (the Early Nutrition Study).

Although some SIDS experts and policy - makers endorse pacifier use recommendations that are similar to those of the AAP, 272,273 concerns about possible deleterious effects of pacifier use have prevented others from making a recommendation for pacifier use as a risk reduction strategy.274 Although several observational studies275, — , 277 have found a correlation between pacifiers and reduced breastfeeding duration, the results of well - designed randomized clinical trials indicated that pacifiers do not seem to cause shortened breastfeeding duration for term and preterm infants.278, 279 The authors of 1 study reported a small deleterious effect of early pacifier introduction (2 — 5 days after birth) on exclusive breastfeeding at 1 month of age and on overall breastfeeding duration (defined as any breastfeeding), but early pacifier use did not adversely affect exclusive breastfeeding duration.

Notwithstanding his superlative boast earlier this year, Governor Andrew Cuomo on Friday described his relationships with New York City Mayor Bill de Blasio in almost clinical terms, offering all - is - well claims that belie the current frostiness between the Democratic politicians.

«Early diagnosis is usually based on clinical signs and symptoms, and cases are often misdiagnosed or left undiagnosed until too late,» said Sambhi.

The findings of the experimental study, presented in the most recent issue of the American Journal of Clinical Nutrition, suggest that improving maternal DHA nutrition has a favorable programming effect on the fetus that influences body composition in early childhood.

Fiers discovered a key protein on the influenza virus that could serve as a target for a universal vaccine; the drug has shown promise in an early clinical trial.

Work on a proof of concept project — code - named Starbrite — began in early 2003 as a collaboration among the Duke Clinical Research Institute (DCRI), Duke Clinic, and CDISC with several technology partners and financial support from several sponsors.

Clinical trials for targeted therapies, selected on the basis of the genomic tests, are scheduled to begin in early 2007.

The FDA had halted early clinical trials of the drug on 3 July, but said on 7 August that the drug could potentially be given to infected patients.

Professor Arnie Purushotham, Cancer Research UK's senior clinical adviser, said: «One of the challenges when treating early stage breast cancer is trying to minimise the side effects that can have a real impact on a woman's life, without affecting the chances of curing her.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

The company hopes that early next year it will initiate clinical trials on product safety, which will pave the way for human efficacy testing that could be completed by 2011.

A somewhat obscure study on statistical methods published in 2009 by medical statistician Ying Lu at Stanford University, California in a specialty journal on clinical trials, was downloaded 2000 times in early August, making it the hottest paper among Stanford University's 5439 registered users.

An early - stage clinical study by another institution, published in the Lancet Oncology in May 2016, combined chemotherapy with an experimental drug that blocks CCR2, a receptor on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.

Developing the idea into presentable form while working together across departments, on top of the regular workload, is an important early achievement, says Anil Dutta, vice president, clinical R&D and medical affairs, GSK Biologicals.

A health - agency windfall includes funding for two promising clinical trials, one focusing on prevention and the other on early treatment

«Poor dietary choices are generally made relatively early in life and, if remained unchanged, can lead to clinical cardiovascular disease later on.

The lead researcher for the study, Professor Gita Mishra, Professor of Life Course Epidemiology and Director of the Australian Longitudinal Study on Women's Health at the University of Queensland, Australia, said: «If the findings from our study were incorporated into clinical guidelines for advising childless women from around the age of 35 years who had their first period aged 11 or younger, clinicians could gain valuable time to prepare these women for the possibility of premature or early menopause.

Since the development of the earliest clinical hematology analyzers, automated cell counting based on cellular shapes has been a staple technique of medical and basic research laboratories.

Dr. Sparano continued: «This is the first prospectively conducted clinical trial evaluating this assay — or any multigene expression assay for that matter — in which patients with early stage breast cancer were uniformly treated based on their assay results.

«Once additional key clinical and genetic factors are identified, infants who are determined to have a low risk of requiring medication can be sent home without prolonged monitoring, and those who are predicted to have a difficult clinical course can be started on more aggressive treatment earlier, which will lead to shorter hospitalizations and improved outcomes.»

«Part of what was exciting about the design of this clinical trial is that we decided early on to accept women from a younger and generally sicker population than is typically enrolled in clinical trials,» says Dr. Cristofanilli, who is also a researcher at the Sidney Kimmel Cancer Center at Thomas Jefferson University.

Early detection will also rely on brain imaging and other clinical signifiers.

White and colleagues will work with other collaborators at the Cancer Institute to develop early - phase patient clinical trials based on the findings from this study in the near future.

Integrated research and clinical training; programs usually offer mentoring for trainees to choose a lab early in their training process, so they can embark on their research right away when they start full - time in the lab;

A 2010 study by William Jarrold, a cognitive scientist at the University of California, Davis, suggests that an automated system that analyzes speech patterns on phone calls can potentially pick up on cognitive impairment and clinical depression or determine if someone is in the very early stages of Alzheimer's.

Although this study is limited by the lack of data on the effects of clinical interventions and neonatal resuscitation efforts that may have been performed at the time of birth, these findings suggest that early detection of perinatal asphyxia is particularly relevant among infants of overweight and obese women although more studies are necessary to confirm these results in other populations.

But Massachusetts's colleges and universities have had an eye on industry for more than a decade, Griesemer says, citing the addition of bioinformatics to computer science programs and clinical trials training to medical school curriculums as early examples.

«What we found early on was not all mice will mate with each other,» says clinical psychologist Melissa Farmer, who led the study while earning her Ph.D. at McGill University in Montreal, Canada.

An initial clinical trial of simvastatin in people with early - stage MS showed reductions in brain lesions, suggesting an effect on the underlying disease process.

Early on in the Iraq War, clinical psychologist Albert «Skip» Rizzo stumbled upon the video game Full Spectrum Warrior and determined to make a therapeutic tool out of it.

However, he believes that both Dr. Simmons» findings concerning hippocampal volume and his study on plasma Aβ concentrations suggest that the AD - suggestive alterations begin perhaps 20 - 30 years before the onset of clinical symptoms, but most probably not earlier.

It is still too early to think about its clinical application, but the work reveals a new genetic target on which to look for new possible therapeutic strategies.

Appel and Sacks led three earlier clinical trials that tested ways to reduce the risk of cardiovascular disease and diabetes, providing volunteers with carefully designed diets and measuring the effects on key health indicators.