Sentences with phrase «on efflux»

In - vitro cell culture assays were used to analyze the effect of MIA - 602 on efflux pump function.

For this study, the researchers focused on efflux pumps inside the bacteria Pseudomonas aeruginosa, which can cause serious illnesses such as pneumonia and sepsis.

Not exact matches

The UTSW experiment focused on Escherichia coli (E. coli) and bacterial pathogens with genetically similar efflux pump complexes.

The Solution: Working with pathogenic bacteria would be far too dangerous in a school setting, so Delgado focused on disabling an efflux pump in the common bacterium E. coli.

Heterogeneity in a bacterial population that arises through a mechanism of biased partitioning of drug efflux pumps, as we identified in our study, could be a stepping - stone on the path of bacterial populations towards antibiotic resistance.»

The team focused on one efflux pump protein, known as AcrA, which connects two other proteins in a tunnel shape through the bacterial cell envelope.

They plan to leverage a recently awarded Innovative and Novel Computational Impact on Theory and Experiment (INCITE) allocation from DOE to perform larger simulations on the Titan supercomputer to gain deeper understanding of how bacterial efflux pumps function, identify more potent efflux pump inhibitors and optimize the best antibiotic - plus - inhibitor combinations to make them suitable for clinical trials.

Laminin cultured cells arrange themselves in lobule like structures, express MRP1 and MRP2 and are capable of biliary efflux and show significant effect on hepatocyte P450 enzyme metabolic activity.

: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

Introduction: This study evaluated the effects of an antagonistic analog of growth hormone - releasing hormone, MIA - 602, on tumor growth, response to doxorubicin, expression of drug resistance genes, and efflux pump function in human triple negative breast cancers.

We examined the effects of treatment on tumor growth, drug resistance, GHRH - R levels, expression of MDR1 and Nanog, and efflux pump activity.

Importantly, cisplatin toxicity and Pgp efflux transporter activity measured on - chip more closely mimic the in vivo responses than results obtained with cells maintained under conventional culture conditions.

Based on unpublished lab experiments Biocidin breaks down biofilms and decreases antibiotic resistance by blocking efflux pumps that remove antibiotics from germs.

An effect of walnuts on ex vivo cholesterol efflux was observed with whole serum but not apoB - depleted serum; in addition to HDL, LDL can serve as an acceptor of free cholesterol in the reverse cholesterol transport pathway (39), indicating that walnuts may have a greater effect on global cholesterol efflux than HDL - specific efflux.

The steady state level of atmospheric CO2, in geological time, is dependent on the input rate and the efflux rate.