Data obtained on the effects of kahweol
on endothelial cell invasion (as determined by a continuous fluorescent assay) clearly show that kahweol induces an anti-invasive effect in HUVEC in a dose - dependent manner (Figure 7).
Not exact matches
Since
invasion is dependent
on extracellular matrix remodeling capabilities, this inhibitory effect strongly suggested that the two key extracellular membrane remodeling enzymes expressed by
endothelial cells, namely, MMP - 2 and uPA could be other main key targets of the pharmacological action of kahweol
on endothelial cells.
We show for the first time that kahweol is an anti-angiogenic compound with inhibitory effects in two in vivo and one ex vivo angiogenesis models, with effects
on specific steps of the angiogenic process:
endothelial cell proliferation, migration,
invasion and tube formation
on Matrigel.