Sentences with phrase «on epithelial cells»

Ciliary dyskinesis - This is a syndrome which has been reported in the Chinese Shar - Pei in which the cilia (microscopic hair - like projections on the epithelial cells which line the upper airways) are malformed or nonexistent.

Other ophthalmic signs can include keratitis (inflammation in the cornea) and corneal ulceration due to the direct cytopathic effect on epithelial cells.

MUC1 is protein found on epithelial cells, such as those that line the intestine, that is overexpressed in many cancers, including colorectal and breast cancers.

The study team assessed three sets of outcomes: a maturational index (MI) based on epithelial cells from the children's urogenital tissue; ultrasound measurements of uterine, ovarian and testicular volume, as well as breast - buds; and hormone concentrations seen in blood tests.

The receptor is often expressed on epithelial cells, the type of cells that turn cancerous, and it promotes cell survival.

Not exact matches

It then travels down the respiratory tract and binds to epithelial cells lining the lung airways via specific molecules on the cell surface.

«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

Vitamin A deficiency and measles both degrade epithelial cells, the protective coating on the organs, which is why secondary infections are much more common and much more severe in acutely malnourished children.

A membrane — designed to support the cultivation and differentiation of human nasal epithelial stem cells — was inserted into a small chamber on the device and fresh or contaminated air was fed through a tiny channel.

The «dry» form is caused by natural deposits on the retina that gradually kill retinal pigment epithelial cells.

Human nasal epithelial cells, cultured on a microchip, react to air pollutants just like they would in the upper airway.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

The team also analyzed the effects of IL - 10 on epithelial wound closure in vitro using an intestinal epithelial cell line.

Bode believes these sugars, because they are indigestible, journey intact to the colon, where their structure mimics molecules on the surface of gut epithelial cells.

In further tests, he and his colleagues designed a mutated version of the botulism compound, based on the novel crystal structure, in which HA would not bind with the epithelial cell protein E-cadherin.

Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells.»

According to this study, it's this NS2 protein and its effect on epithelial - cell shedding that makes RSV by far the most common cause of bronchiolitis in otherwise healthy young children.

The airway epithelial cells that the method relies on are continuously shed, he notes.

The research team was also able to shed more light on the role of Paneth cells — a type of cell found in the epithelial lining of the small intestine.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually called on — and whether normal epithelial cells begin to exhibit the behaviors characteristic of highly malignant cancer cells.

HER2 - positive breast cancer, which is associated with poor prognosis, has been traced to an excess of signaling through receptors, or docking ports, called HER2 found on the surface of certain mammary epithelial cells.

It has been designed for treating the «dry» form of macular degeneration, caused by deposits on the retina gradually killing retinal pigment epithelial cells, which support light - capturing cells.

According to Dr. Bleich and his co-investigators, «Epithelial barrier function is predominantly dependent on tight junction proteins, which regulate transport into and between cells.

Because airway epithelial cells are tightly connected, the researchers posited that the membrane proteins on opposite sides don't normally mix.

When normal cells are transformed into cancer cells, this epithelial tissue can take on the characteristics of embryonic tissue, known as mesenchymal tissue, which is comprised of unspecialized cells that will develop, as the embryo matures, into more specialized tissues.

An instructive model of EMT is based on an experimental system employing normal primary human mammary epithelial cells (HMECs).

Effects of microRNA - 211 on proliferation and apoptosis of lens epithelial cells by targeting SIRT1 gene in diabetic cataract mice.

Thirdly, the current, almost universal dependency of organoid culture on the use of Matrigel as a replacement for the function of the extracellular basement matrix in providing structural support and survival signals to the epithelial cells hampers clinical application, considering its origin from a mouse sarcoma cell line, its poorly defined composition and its mechanical rigidity after plating.

Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing human alveolar epithelial cells and capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.

Protocols to grow organoids as polarized monolayers of epithelial cells on membranes or filters are already in place for the intestine, gall bladder, liver and pancreatic ducts (21).

Biological Function of Ribosomal Protein L10 on Cell Behavior in Human Epithelial Ovarian Cancer Jimin Shi, Lingyun Zhang, Daibing Zhou, Jinguo Zhang, Qunbo Lin, Wencai Guan, Jihong Zhang, Weimin Ren, Guoxiong Xu J. Cancer 2018; 9 (4): 745 - 756.

Jens - Christian Roeper (Eaton, MPG)-- «The influence of cell mechanics, cell - cell interactions and proliferation on epithelial packing» (2009)

The effects of combination glaucoma medications on ocular surface epithelial cells.

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected.

Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alphavbeta6 on porcine trophectoderm cells and integrin alphavbeta3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.

Pharmacologic Effects of 2 - Methoxyestradiol on Angiotensin Type 1 Receptor Down - Regulation in Rat Liver Epithelial and Aortic Smooth Muscle Cells % U http://www.sciencedirect.com/science/article/pii/S1550857912000484.

In vitro toxicity of topical ocular prostaglandin analogs and preservatives on corneal epithelial cells.

Orientation of actin filaments in teleost retinal pigment epithelial cells, and the effect of the lectin, Concanavalin A, on melanosome motility.

Here we describe a method for fabricating a primary human Small Intestine - on - a-Chip (Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal biopsies.

Normal breast tissue showed acini lined by epithelial cells resting on an intact myoepithelial cell layer (Figure 1A).

Skin substitutes involve different cell composites, such as: fibroblasts, keratinocytes, epithelial cells and / or MSCs transplanted on membranes or with supportive matrix.

In particular, they are focused on studying the functional role and molecular mechanisms of cellular senescence in both of these events, and how a deregulation of normal epithelial stem cell proliferation is involved.

The HUB is founded on the pioneering work of Hans Clevers, M.D., Ph.D., who discovered methods to grow stem cell - derived human epithelial mini-organs from the tissues of patients with various diseases.

In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell necrosis and airway cellular debris (figure 2A).

Limbal epithelial stem cells sheets cultured on amniotic membranes for treatment of limbal stem cell deficiency (LSCD).

The primary epithelial cells are expanded as 3D organoids, dissociated, and cultured on a porous membrane within a microfluidic device with human intestinal microvascular endothelium cultured in a parallel microchannel under flow and cyclic deformation.

LIGHT can bind LTβR, a TNFR family molecule constitutively expressed on stromal cells, dendritic cells, macrophages, and some epithelial cells.

The program has a strong emphasis on breast epithelial cell and molecular biology, basic science driven translational and clinical research, and molecular epidemiology.

They found that amnioserosa cells pulse throughout their life, constantly contracting and relaxing their surfaces.With each contraction they transiently pull on the surrounding epithelial cells, and then relax, letting them go.