Dr. Worthey received her Ph.D. in Genetics from the University of London in 2003 and completed her postdoctoral fellowship at the Seattle Biomedical Research Institute at the University of Washington, working
on both Eukaryotic Genomics and other high throughput «Omics» projects.
As is often the case for yeast, the ability to sequence and analyze whole genomes at very deep coverage has yielded broad insights
on eukaryotic genome evolution.
External and internal constraints
on eukaryotic chemotaxis.
UC Davis has received funding to host an SMBE Satellite Meeting
on Eukaryotic - Omics this spring — meeting dates have been set as Monday April 29 — Thursday May 2nd, 2013, and further details can be found at the meeting website: http://www.smbe.org/eukaryotes
Broad beginning in December 2012 filed a dozen patents based
on the eukaryotic use of CRISPR, and paid the U.S. Patent and Trademark Office (USPTO) to do a fast - track review.
«The key unanswered question here concerns when
on the eukaryotic line the eukaryotic type of cell formed.
Not exact matches
The consensus
on the evolution of primitive life is that simple life forms (prokaryotes, organisms whose cells lack a distinct nucleus) inhabited the Earth about 3 - 4 billion years ago,
eukaryotic cells (those with a nucleus which contains the genetic material) emerging 2 - 3 billion years ago.
Over eons, pieces of mitochondrial DNA have naturally inserted into
eukaryotic genomes; at birth, for example, humans have between 755 and 1,155 germline mitochondrial DNA inserts that have been passed
on through generations.
AS A species made up of
eukaryotic cells complete with mitochondria, nuclei and other complex structures, it's easy for us Homo sapiens to look down
on the far simpler prokaryotes, the cells of which lack such structures.
Our current concept of the origin of the
eukaryotic cell is in flux, however, and an evolutionary sequence that appears simple when conceptualized
on a phylogenetic tree diagram may be far more complex and interesting in reality.
Nevertheless, the
eukaryotic stem
on the phylogenetic tree of life spawns many branches before one gets to the split that separates the ancestors of plants from the ancestors of animals, which seems to have happened more than a billion years ago.
So those conditions could have put a brake
on the expansion of
eukaryotic cells.
But in an Opinion paper published June 16 in Trends in Cell Biology, researchers propose that new genomic evidence derived from a deep - sea vent
on the ocean floor suggests that the molecular machinery essential to
eukaryotic life was probably borrowed, little by little over time, from those simpler ancestors.
The EBP would focus
on the natural world, providing a better understanding of biodiversity by first sequencing in great detail the DNA of a member of each
eukaryotic family (about 9000 in all) and eventually generating coarser genomes for the other eukaryotes.
If — as in the
eukaryotic ubiquitin - based system — the access to the protease depends
on a specific tag that must be carried by the substrate, then the important decision who and when should be eliminated boils down to the timely and selective attachment of tags.
In last week's filing, attorneys for the Broad Institute asked patent officials to remove two of its issued patents that focus
on saCas9 from the original case, as well as two other patents (and a few affiliated claims in other patents) that describe techniques for enabling the CRISPR - Cas9 construct to target the nucleus of a
eukaryotic cell.
In this weeks» edition of Nature, researchers from Uppsala University in Sweden, along with collaborators from the USA, Japan, Denmark and New Zealand report the discovery of a new group of Archaea, the Asgard archaea, which reveal important details
on how
eukaryotic cells evolved their complexity.
The predicted hosts for the Klosneuviruses are protists (single - celled
eukaryotic (nucleus - containing) microorganisms) and while their direct impacts
on protists are not yet worked out, these giant viruses are thought to have a large impact
on these protists that help regulate the planet's biogeochemical cycles.
These have provided insight into the roles that marine bacteria, archaea, viruses and
eukaryotic microbes have as global primary producers that provide nutrition at the base of the food chain; remineralization (the transformation of organic molecules into inorganic forms); and the deposition of carbon
on the sea floor.
The rapid onset of the freezing phenotype led to the hypothesis that Mcf1 may be acting
on a pre-existing
eukaryotic molecular switch governing actin cytoskeletal dynamics such as the rho GTPases.
It is now recognized as one of the most important evolutionary innovations of life
on our planet, and contributed to the origin of
eukaryotic cells, which which humans are made of.
On oxygenated seafloors, the first multi-cellular lifeform (possibly an
eukaryotic alga) appears to have evolved by Year 2.4 billion as the 12 - centimeter or 4.7 - inch protoctist, Grypania (more from BBC News and New Scientist).
Although atmospheric oxygen soon recovered again as photosynthesis and weathering reached a new balance, at about 10 per cent of present - day levels, the oxidative weathering of sulphides
on land filled the oceans with sulphate which created abundant food for a group of bacteria that filled the oceans with sewer gas (hydrogen sulphide) toxic to oxygen - loving lifeforms (delaying the development of
eukaryotic plants and animals) and turned them «into stinking, stagnant waters almost entirely devoid of oxygen.»
The
Eukaryotic Single - Cell Analysis facility will be placed in Stockholm and will offer single - cell RNA - seq
on the Fluidigm C1 platform using the STRT protocol, as well as in a microtiter - plate format using SMART - seq2.
2) Tectonic plates 3) That mitochondria are prokaryotes living in a
eukaryotic cell 4) that the earth goes round the sun I think that's a few to be going
on with:) per
Our method, based ideally
on 20x and 50x of NaS and Illumina reads respectively, provides an efficient and cost - effective way of sequencing microbial or small
eukaryotic genomes in a very short time even in small facilities.
The CellDevo Track focuses
on the study of molecular mechanisms in
eukaryotic cells and their role in tissue formation, with the level of analysis ranging from single molecules to single cells, from cells to tissues, and from tissues to whole organisms.
The team's work highlights this by presenting a comprehensive view of genome evolution
on many different levels (e.g., differences in ploidy, aneuploidy, genetic variants, hybridization, and introgressions) that is difficult to obtain at the same scale and accuracy for other
eukaryotic organisms.
Fox and colleagues applied for a PSI grant in 2000, and
on the strength of their science and Wisconsin's structural biology depth, they received funding in 2001 to create the Center for
Eukaryotic Structural Genomics.
«This is the only system I know about that is amenable for structural work
on how the cellular signal comes down to the chromatin and DNA and that can provide an answer about how a signal activates a
eukaryotic gene,» Panne says.
Liron Bar - Peled, Grand Prize winner and Cell & Developmental Biology category winner, told about his research
on the enzyme mTORC1 which regulates
eukaryotic cell growth and is deregulated in some common cancers and diabetes.
The transcription factors usually function as homodimers or heterodimers to regulate the gene expression in
eukaryotic cells and their activities are dependent
on distinct protein - protein interaction.
Kim Orth of the University of Texas Southwestern Medical Center and the Howard Hughes Medical Institute has worked to elucidate the activity of bacterial virulence factors
on the molecular level, providing insights into how bacteria cause disease and how
eukaryotic host cells signalin response to infection.
His findings suggest that
eukaryotic organisms were present
on Earth as early as 2.31 billion years ago, around the same time that oxygen was first present in the Earth's atmosphere.
Our aim is to shed light
on the evolutionary path by which archaeal proteins gave rise to the
eukaryotic cytoskeleton.
These newly identified organisms might have a big impact
on our understanding of the deeper branches of the tree of life giving us new hints about the emergence of the
eukaryotic cell.
My research is framed within the Wellcome Trust consortium
on the archaeal origins of
eukaryotic cell organization (http://evocyt.com/), which includes a diverse group of researchers studying the evolution of
eukaryotic machinery from different points of view — e.g. how do specific cellular systems work in different lineages, and how did that affect the origin of the
eukaryotic cell plan?
Data from such investigations provide a unique perspective
on the events in this time period, and together present a cohesive framework for examining
eukaryotic and animal evolution through the Proterozoic and into the Phanerozoic Eon.
His basic research is focused
on understanding how
eukaryotic mRNAs recruit ribosomes, how ribosomes subsequently locate initiation codons, and how ribosomes regulate the translation of specific subsets of mRNAs.
The microbiome is a community of healthy bacteria, viruses, archaea, and
eukaryotic microbes that live
on our skin and inside our body.
Depression indicates a flare of inflammation so you may need to improve your gut flora, or you might have some
eukaryotic (protozoal, fungal) infection that is worsened
on a ketogenic diet.
Includes questions
on centrifugation, cell organelles,
eukaryotic and prokaryotic cells, adaptations to functions, microscopes and viruses.
From seed and spore dispersal, to rapid cell growth of
eukaryotic organisms, and the pulsing cilia needed to sustain them, to the slow growth of lichens and moss - life has a remarkable way of establishing itself
on the planet; yet, most of these processes go unseen to the human eye.