Sentences with phrase «on fibrotic»
Previously Dr. Martini worked at Shire plc in Lexington, Mass., as Senior Director of Discovery Biology and Translational Research, Mass., focusing on fibrotic diseases of muscle, kidney, skin, lung, bone marrow and metabolic liver diseases, with particular emphasis on different therapeutic modalities for pathway modulation.
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On the contrary, senescence is decreased in activated hepatic stellate cells (HSCs), the supportive cells which, when triggered by alcohol or other liver insults, begin to produce excessive fibrotic material.
The firm dropped discovery and development in the areas of diabetes, virology, and neuroscience in favor of a research focus on oncology, heart failure, genetically defined diseases, immunoscience, and fibrotic diseases.
«Current cancer treatment often focuses on targeting cancer cells, but is not focused on targeting the fibrotic connective tissue, that may develop first, before you have cancer.
This is important because many different pro-fibrotic signaling pathways converge on the genome to affect their fibrotic response.»
Research Focus: My research projects are focused on the roles of TNF family members linked to fibrotic disorders associated with scleroderma, atopic dermatitis, idiopathic pulmonary fibrosis and asthma.
In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.
One study of Chinese children consuming rapeseed oil indicated an association with Keshan's disease, which causes fibrotic lesions on the heart (2).