Sentences with phrase «on gene expression patterns»

Effects of ploidy and sex - locus genotype on gene expression patterns in the fire ant Solenopsis invicta.

The application of transgenesis and other genetic methods - in conjunction with total genome sequence and database information on gene expression patterns, morphological changes during development, and mutant phenotypes - should significantly enhance our ability to unravel the multilayered networks that control gene expression and differentiation.

They examined the effect of meditation on gene expression patterns in both novice and regular meditators.

Not exact matches

In the clearest possible case, the ANT - OAR cell would differ from a zygote on all of the parameters noted above: The ANT - OAR cell would have a pattern of gene expression that is clearly distinct from a zygote; it would generate a homogeneous population of cells rather than multiple cell types; it would undergo simple cleavage divisions and not produce any multicellular structures.

Once the pattern of expression of these genes had been identified, Prof. Khatri and his colleagues tested it out on the remaining 900 samples from patients with different tropical diseases and from healthy people.

Indeed, the group found that the affected gene, named left - right dynein (lrd), comes on in the «node» — a key source of patterning signals — just before the appearance in the mouse embryo of the first known left - right asymmetries, the left - sided expression of two genes called nodal and lefty.

Another version, the CTC - iChip, rapidly isolates CTCs in a way that does not rely on preidentified tumor antigens, allowing capture of cells with gene expression patterns that may be missed by the antibodies used in the HBCTC - Chip.

Horvath and Tell observed that there are many clearly visible patterns of common gene expression — where certain genes are turned on and certain genes are turned off — in the basal - like cancers.

In cells grown on flat culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the cells from those dishes had been unable to generate new hair follicles.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

The epigenetic pattern consists of molecules known as methyl groups, which are placed on the genes and affect their function and gene expression.

But brain cells that had been created using the direct conversion technique had different patterns of gene expression depending on whether they were created from young donors or older adults.

Bhaduri then used statistical algorithms to cluster different cells based on their patterns of gene expression.

Because genes on the Y chromosome often vary slightly in sequence — and even function — from the corresponding genes on the X, males could have slightly different patterns of gene expression throughout the body compared with females, due to not only their hormone levels, but also their entire Y chromosome.

They are driven by stem cells with the proneural pattern of gene expression and depend on rapid cell division and angiogenesis — creation of new blood vessels.

Still others are working to overlay gene - expression patterns, electrophysiological measurements or other functional data on those maps.

A careful examination of tassel development in the maize BR mutants, and evaluation of gene expression patterns during BR loss and GA supplementation, may help shed light on links between these two systems.

The process used by NIH to select the mouse lines involved a rigorous scientific review process that evaluated information on the knocked out gene, the reliability of the method used to produce the knockout, and whether the mouse line possesses a «reporter» gene, which enables researchers to analyze the pattern of the knockout gene's expression in various mouse tissues.

A dizzying number of genetic transcripts, proteins and other molecular players alternatively glom together or fall apart, turning on or tuning down countless patterns of gene expression that keep our cells, organs and bodies humming along with the Earth's daily rotations.

«The authors went on to study the resulting blastocysts for aneuploidy (frequency of abnormal chromosomes), and pattern of gene expression (which genes are active and at what level).

By arraying nearly 18,000 genes on a glass chip about twice the size of a postage stamp and recording the expression patterns of those genes, researchers have obtained detailed molecular portraits of...

Further discussion on detectable and tissue specificity expression and gene expression patterns across tissues can be found here25.

A reliability score is set manually for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA / gene characterization data from both HPA and the UniProtKB / Swiss - Prot database.

The gene - of - interest is first inspected on three aspects in the BXD GRP, i.e. the existence of genetic variations, e (p) QTLs, and its expression pattern across strains.

A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA / gene characterization data.

This gene was confirmed as the Nasonia ortholog of doublesex based on protein domains, expression pattern, sex specific splice forms, and experimental demonstration that splice forms are associated with sex in a gynandromorph producing line [18].

We identify no overt pattern in the expression of either VR or OR genes based on cluster or genomic location (Figure 4, 5).

«So far, we have been comparing the expression patterns of normal, preneoplastic and tumor tissue on chips that let us look at 7,000 genes at once,» Chen said.

It has been demonstrated that the composition of the medium used for embryo culture has a profound effect on the methylation pattern in the resultant two - cell embryos [10], indicating that, in addition to imprinted genes, other epigenetic alterations may intensely modify gene expression.

After clicking on any of the panels, for example on the top left panel marked with a red asterisk, the expression profiles of the individual genes that follow the corresponding pattern as well as their names appear in a new window (as shown in B).

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clustgene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseexpression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clustGene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseExpression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseexpression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseexpression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

During development, genes within specific cell types are turned on and off to trigger the necessary expression patterns that create a whole animal.

The authors identify ten sub-regions based on differential gene expression, combining the expression patterns of GAL4 driver lines and RNA seq. of dissected segments of the gut.