Sentences with phrase «on gene families»

The Lexicon efforts are focused on gene families that are pharmaceutically important, such as transporters, G - protein coupled receptors (GPCRs), ion channels, kinases and other key enzymes, membrane proteins (e.g., receptors), and secreted proteins.

«Currently, we are conducting a series of joint investigations on gene family evolution and adaptation genomics in plants with colleagues at the Chinese Academy of Sciences, and we foresee more significant results from this collaboration,» says Xiao - Ru Wang.

Not exact matches

Another process called epigenetics that switches genes on and off may explain why ho - mose - xuality runs in families.

No doubt ideas of kin altruism (the mutual support extended between those who share in the family gene pool) and reciprocal altruism (favors done in the expectation of favors later to be received) shed some Darwinian light on aspects of human behavior.

Jeter's family was on the field before the Yankees - Tigers game for a pregame ceremony and Jalen Jeter showed off his cap tipping genes.

Our children must have received their genes from other parts of the family because we do have a lot of height on both sides, my husband and I just don't have it.

While men can carry the gene and pass it on to their daughters, a family history of twins doesn't make them any more likely to have twins themselves.

Some mothers aren't able to breast feed for medical reasons, so «wishing a gene pool would die off» because a family has to rely on formula vs. breast milk is absurd and to dignify that comment with more time - well it would probably be inappropriate.

But your husband's family history has absolutely no bearing on your own children, except maybe for the future possibility that you might have twin grandchildren — if you have a daughter who inherits the hyperovulation gene.

This family resemblance is something that many adoptive parents envy — they wish they could see their own genes passed on to another generation.

Fahey, on the other hand, is an unknown, although the family name carries some cache thanks to his cousin, Gene Fahey, the widely respected judge and former city councilman.

The study sheds light on the mechanisms and adaptive significance of gene family evolution.

Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

«Our work shows that not only do people with ASD have fewer children than others,» he said, «but in families where a child has ASD, the fact that the parents choose to have fewer children means the genes that predispose to ASD are less likely to be passed on to future generations.»

Together, the researchers focused on a family of genes that encode taste receptors found in fruit flies.

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

Brin writes on his blog that the genome scan of his saliva from 23andMe told him he has a mutation on the LRRK2 gene, a variation called G2019S, which ups the risk for Parkinson's in some families.

To understand the genetic shifts underlying the repeated origins of mycorrhizal lifestyles, the researchers focused on enzymes that degrade plant cell walls from 16 gene families associated with plant cell wall degradation.

But in a closer study of 73 families researchers found a region of genes on chromosome eight in those with perfect pitch and from European ancestry.

The system relies on admixture — a genetic principle that argues that when a family migrates across a geographic barrier into a new location, they start mating with the locals; new traits start blending into their gene pool, and this genetic diversity provides a ruler for gauging the distance from home.

Until now, de novo genetic mutations, alterations in a gene found for the first time in one family member, were believed to be mainly the result of new mutations in the sperm or eggs (germline) of one of the parents and passed on to their child.

Studies of the affected families had previously determined that the Werner gene must lie somewhere on chromosome 8.

In 2013 another study will focus on a family in Colombia that carries one of these rogue genes, treating them with the amyloid - fighting drug Crenezumab.

Recent studies showed that low oxygen conditions increase levels of a family of proteins known as HIFs, or hypoxia - inducible factors, that turn on hundreds of genes, including one called NANOG that instructs cells to become stem cells.

She identified a region on chromosome 8 where the affected family members had distinctly different genes.

This network discourages violence, Sheehy speculates, because peaceable interactions may help related males set up their own territories and attract mates, thereby increasing the likelihood that shared family genes get passed on.

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

By comparing this region with the DNA from epileptics from six other families, the researchers gradually homed in on a gene called KCNQ2.

According to calculations by population geneticists based on family trees, one of these survivors carried a recessive gene for achromatopsia, which also causes severe sensitivity to light and poor vision.

Bierut and her colleagues analyzed data gathered through the Collaborative Study on the Genetics of Alcoholism (COGA), a large, multi-center, family study designed to identify genes that contribute to AUDs.

And he expects that fraction to rise considerably when the team continues the research on more families and with more sensitive DNA probes — work that will also help pin down the genes involved.

Alongside its soon - to - be — unveiled physical map, CEPH - Genethon is also leading the world with its efforts to build human «genetic maps» — maps which show the relative positions of thousands of genes, culled from careful genealogical work on the way characteristics are passed on in human families.

In their quest to decipher the complex code of autism, which can run in families, most scientists have focused on genes.

In a similar case with a 12 - year - old whose exome was sequenced without any family data, Phevor built on the analysis of VAAST to identify a gene mutation causing the illness, another autoimmune syndrome.

Prof Bentzen from Dalhousie University said: «Although this study focused on MHC genes in vertebrates, the evolutionary dynamics described in it likely apply to other gene families, for example resistance genes and those which prevent self - fertilization in plants (self - incompatibility loci) that are caught up in their own evolutionary races.»

But suddenly I saw how a mutation in the genes discussed in that article, BRCA1 and BRCA2, might have slipped unnoticed through my father's small family, heavy on the Y chromosome — through him; his older brother; my three cousins, two of whom are male.

When it comes to two of the genes on the panel, BRCA1 and BRCA2, there's little doubt that in cancer - prone families, testing saves lives: Extensive study of BRCA carriers has found that those who have their ovaries removed are 80 % less likely to die from ovarian cancer and 50 % less likely to die from breast cancer.

They focused on adoptive families to limit the possibility that shared genes contributed to links between parents» symptoms of depression and children's outcomes, and to isolate more fully the environmental impact of being raised by a depressed parent.

Ever since the gene for CF was identified in 1989, much debate has centred on whether the general public should be screened to detect carriers, or whether screening should be restricted to affected families.

BET inhibitors reduce tumour growth by blocking BET proteins, a family of proteins that control whether genes are switched on or off.

WHAT HE»S DOING NOW: ISB focuses on «big science» projects like mapping the genes of families prone to prostate cancer.

In addition to the 1,274 genes that take part in coding proteins, they also identified 375 novel noncoding gene families on the bovine Y chromosome, which are predominantly expressed in different stages of the testis.

He focused on human leukocyte antigens (HLAs), a family of about 200 genes that is essential to our immune system.

Previously, genetic counselors tested a small number of genes sequentially based on family profile and tumor analysis until the culprit was identified.

The APOE4 trial builds on another trial of an anti-amyloid drug in 300 members of a Colombian family who carry a gene mutation that places them at high risk of developing an early - onset form of Alzheimer's disease.

To say there's some sort of heritable component to a trait tells us something can be passed on in a family that can contribute to performance, but what are the specific genes?

Additional examination of the two genes in anoxeria - prone families gave the researchers a handle on which DNA sequence variations conferred the most risk.

For instance, in the human genome we still see the remnants of the large olfactory receptor gene family that gave our evolutionary ancestors a keen sense of smell, even though humans no longer rely on them.

The gene is located on chromosome 1, an area that's been scrutinized for prostate cancer genes since 1996, when family studies revealed a link between a region of that chromosome and the disease (ScienceNOW, 21 November 1996).