Sentences with phrase «on gene mapping»

Not exact matches

As the cost for a full gene map approaches $ 1,000, the opportunity increases for business owners to get in on the genome mapping industry.

HGI is a U.S. government - funded project that aspires to identify and map every gene on our 24 chromosomes.

Subtle differences in the genes of more than 2,000 people in England, Scotland, Wales and Northern Ireland reveal 17 distinct groups, represented by different symbols and colors on the map.

This permits high - resolution mapping of genes and chromosomal regions on single fibers of DNA, and it targets the physical location of mitochondrial DNA probes down to a resolution of 1,000 base pairs.

In a study published in Neoplasia, researchers at the Washington University School of Medicine created a map showing which genes were switched on and off in different parts of the tumor, providing a «signature» of these switches throughout the genome.

Using gene mapping techniques, the researchers zeroed in on a mutation in the gene for hypocretin receptor 2.

Based on how the genes fit within the original, mapped profile, they can predict with a high accuracy if a particular patient will develop metastatic tumors.

But the genetic factors underpinning seed coat permeability remained a mystery until Ma and his team used a map - based cloning approach to hone in on GmHs1 - 1 as the gene responsible for hard seededness.

To learn more, Zanders and her colleagues used genetic mapping to reveal the complex landscape of multiple meiotic drive genes on chromosome 3 of S. kambucha.

The map allows gene hunters to get away with less (and thus cheaper) DNA sequencing while still, it's hoped, homing in on disease genes.

Remarkably, the maps derived from these two processes were closely related and converged on the same Parkinson's genes and cellular processes.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

The current discussion and debate on policy concerned with mental illness represents one peak on the tip of the iceberg explored by the 17 contributors to Gene Mapping.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

Standard mapping procedures depend on homing in on informative coding regions in genes and «walking» along the chromosome, past any uninformative repetitive DNA, to the next gene.

This was the first cancer gene, or oncogene, ever identified — a celebrated breakthrough that truly put the young German on the scientific map.

«When the genome of the black Perigord truffle was mapped in 2010, we thought that the fungus had sufficient genes to create its flavour on its own,» junior professor Richard Splivallo from the Institute for Molecular Life Sciences at the Goethe University explained.

The map is a key tool that geneticists rely on to find disease genes and identify the functional genetic variations at the core of human diversity.

In four tumors, the vector mapped to a section of chromosome 12 and turned on several genes implicated in cancer, the team reports tomorrow in Science.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

The new research focused on just nine genes, those most strongly associated with autism in recent sequencing studies, and investigated their effects using precise maps of gene expression during human brain development.

The resulting repair maps revealed that excision repair in Arabidopsis works faster on genes that are active.

Based on their gene - drug interaction map, the researchers predicted that mutations in two genes, called ARID1A and GPBP1, could contribute to ovarian cancer's ability to develop resistance to this class of drugs.

The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.

«First, there is no single road map to eusociality — the complex, cooperative social system in which animals behave more like superorganisms than individuals fending for themselves,» said Gene Robinson, a lead on the study who is a professor of entomology and director of the Carl R. Woese Institute for Genomic Biology at the University of Illinois.

For instance, he is working on a proposal to map genes that regulate aging in baboons.

CEPH's «first - generation» map, assembled by hundreds of researchers and with financial support from the US National Institutes of Health in Bethesda, is based mainly on the relative positions of genes on chromosomes.

So when the US National Genome Project started three years ago, a group of influential molecular biologists led by James Watson decided that the sensible approach would be to concentrate first on mapping the genes and finding out their functions.

For 10 years Tuomilehto has collaborated with American investigators at the University of Southern California and the University of Michigan on a gene - mapping project for type 2 diabetes, formerly known as adult - onset diabetes.

Alongside its soon - to - be — unveiled physical map, CEPH - Genethon is also leading the world with its efforts to build human «genetic maps» — maps which show the relative positions of thousands of genes, culled from careful genealogical work on the way characteristics are passed on in human families.

Once it is clear where a gene is on the genetic map, researchers can (in theory) simply look at a physical map, which in turn directs them to a particular DNA fragment that should contain their gene.

The more genes or other types of genetic landmarks on the map, the better its resolution — that is, the more precisely the locations of genes can be fixed.

The researchers sequenced the entire genome of C. amylolentus, mapping the location of all the genes as well as the centromeres on each of the organism's 14 chromosomes.

«We know that most of these risk variants on their own play little role in the development of MS.. But mapping the collection of genes associated with MS represents an important advance in efforts to identify the key mechanisms behind its development,» Dr Harbo says.

Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»

More recently, they have begun to seek genes that affect our behavior, prompting us to be dyslexic (chromosome 6), homosexual (perhaps on the X chromosome), adventurous (chromosome 11), or even highly religious (no map location yet).

Uncovering the genetic pathogenesis of Alzheimer's disease has been a target of great interest over the past few years, and genome - wide mapping studies focusing on risk genes have led to significant advances in the field.

WHAT HE»S DOING NOW: ISB focuses on «big science» projects like mapping the genes of families prone to prostate cancer.

Hubbard does not dispute this: what concerns her, rather, is that the intensified effort to «map» the human genome puts too much emphasis on genes and too little on the contexts in which they work — or in which people work.

Scientists have mapped which genes are turned on and off in the different tissues and organs in a sheep's body.

The genes thought to be responsible for many of the pathologies associated with the disorder are being identified and mapped to sites on chromosome 21

Still others are working to overlay gene - expression patterns, electrophysiological measurements or other functional data on those maps.

For example, many studies on human microbiota identify species (or operational taxonomic units) and map evolutionary relationships using the 16S ribosomal RNA gene.

And the trees based on other genes show different maps that do not agree with the ribosomal RNA map.

g (acceleration due to gravity) G (gravitational constant) G star G1.9 +0.3 gabbro Gabor, Dennis (1900 — 1979) Gabriel's Horn Gacrux (Gamma Crucis) gadolinium Gagarin, Yuri Alexeyevich (1934 — 1968) Gagarin Cosmonaut Training Center GAIA Gaia Hypothesis galactic anticenter galactic bulge galactic center Galactic Club galactic coordinates galactic disk galactic empire galactic equator galactic habitable zone galactic halo galactic magnetic field galactic noise galactic plane galactic rotation galactose Galatea GALAXIES galaxy galaxy cannibalism galaxy classification galaxy formation galaxy interaction galaxy merger Galaxy, The Galaxy satellite series Gale Crater Galen (c. 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(1940 ---RRB- Gauer - Henry reflex gauge boson gauge theory gauss (unit) Gauss, Carl Friedrich (1777 — 1855) Gaussian distribution Gay - Lussac, Joseph Louis (1778 — 1850) GCOM (Global Change Observing Mission) Geber (c. 720 — 815) gegenschein Geiger, Hans Wilhelm (1882 — 1945) Geiger - Müller counter Giessler tube gel gelatin Gelfond's theorem Gell - Mann, Murray (1929 ---RRB- GEM «gemination,» of martian canals Geminga Gemini (constellation) Gemini Observatory Gemini Project Gemini - Titan II gemstone gene gene expression gene mapping gene pool gene therapy gene transfer General Catalogue of Variable Stars (GCVS) general precession general theory of relativity generation ship generator Genesis (inflatable orbiting module) Genesis (sample return probe) genetic code genetic counseling genetic disorder genetic drift genetic engineering genetic marker genetic material genetic pool genetic recombination genetics GENETICS AND HEREDITY Geneva Extrasolar Planet Search Program genome genome, interstellar transmission of genotype gentian violet genus geoboard geode geodesic geodesy geodesy satellites geodetic precession Geographos (minor planet 1620) geography GEOGRAPHY Geo - IK geologic time geology GEOLOGY AND PLANETARY SCIENCE geomagnetic field geomagnetic storm geometric mean geometric sequence geometry GEOMETRY geometry puzzles geophysics GEOS (Geodetic Earth Orbiting Satellite) Geosat geostationary orbit geosynchronous orbit geosynchronous / geostationary transfer orbit (GTO) geosyncline Geotail (satellite) geotropism germ germ cells Germain, Sophie (1776 — 1831) German Rocket Society germanium germination Gesner, Konrad von (1516 — 1565) gestation Get Off the Earth puzzle Gettier problem geyser g - force GFO (Geosat Follow - On) GFZ - 1 (GeoForschungsZentrum) ghost crater Ghost Head Nebula (NGC 2080) ghost image Ghost of Jupiter (NGC 3242) Giacconi, Riccardo (1931 ---RRB- Giacobini - Zinner, Comet (Comet 21P /) Giaever, Ivar (1929 ---RRB- giant branch Giant Magellan Telescope giant molecular cloud giant planet giant star Giant's Causeway Giauque, William Francis (1895 — 1982) gibberellins Gibbs, Josiah Willard (1839 — 1903) Gibbs free energy Gibson, Edward G. (1936 ---RRB- Gilbert, William (1544 — 1603) gilbert (unit) Gilbreath's conjecture gilding gill gill (unit) Gilruth, Robert R. (1913 — 2000) gilsonite gimbal Ginga ginkgo Giotto (ESA Halley probe) GIRD (Gruppa Isutcheniya Reaktivnovo Dvisheniya) girder glacial drift glacial groove glacier gland Glaser, Donald Arthur (1926 — 2013) Glashow, Sheldon (1932 ---RRB- glass GLAST (Gamma - ray Large Area Space Telescope) Glauber, Johann Rudolf (1607 — 1670) glaucoma glauconite Glenn, John Herschel, Jr. (1921 ---RRB- Glenn Research Center Glennan, T (homas) Keith (1905 — 1995) glenoid cavity glia glial cell glider Gliese 229B Gliese 581 Gliese 67 (HD 10307, HIP 7918) Gliese 710 (HD 168442, HIP 89825) Gliese 86 Gliese 876 Gliese Catalogue glioma glissette glitch Global Astrometric Interferometer for Astrophysics (GAIA) Global Oscillation Network Group (GONG) Globalstar globe Globigerina globular cluster globular proteins globule globulin globus pallidus GLOMR (Global Low Orbiting Message Relay) GLONASS (Global Navigation Satellite System) glossopharyngeal nerve Gloster E. 28/39 glottis glow - worm glucagon glucocorticoid glucose glucoside gluon Glushko, Valentin Petrovitch (1908 — 1989) glutamic acid glutamine gluten gluteus maximus glycerol glycine glycogen glycol glycolysis glycoprotein glycosidic bond glycosuria glyoxysome GMS (Geosynchronous Meteorological Satellite) GMT (Greenwich Mean Time) Gnathostomata gneiss Go Go, No - go goblet cell GOCE (Gravity field and steady - state Ocean Circulation Explorer) God Goddard, Robert Hutchings (1882 — 1945) Goddard Institute for Space Studies Goddard Space Flight Center Gödel, Kurt (1906 — 1978) Gödel universe Godwin, Francis (1562 — 1633) GOES (Geostationary Operational Environmental Satellite) goethite goiter gold Gold, Thomas (1920 — 2004) Goldbach conjecture golden ratio (phi) Goldin, Daniel Saul (1940 ---RRB- gold - leaf electroscope Goldstone Tracking Facility Golgi, Camillo (1844 — 1926) Golgi apparatus Golomb, Solomon W. (1932 — 2016) golygon GOMS (Geostationary Operational Meteorological Satellite) gonad gonadotrophin - releasing hormone gonadotrophins Gondwanaland Gonets goniatite goniometer gonorrhea Goodricke, John (1764 — 1786) googol Gordian Knot Gordon, Richard Francis, Jr. (1929 — 2017) Gore, John Ellard (1845 — 1910) gorge gorilla Gorizont Gott loop Goudsmit, Samuel Abraham (1902 — 1978) Gould, Benjamin Apthorp (1824 — 1896) Gould, Stephen Jay (1941 — 2002) Gould Belt gout governor GPS (Global Positioning System) Graaf, Regnier de (1641 — 1673) Graafian follicle GRAB graben GRACE (Gravity Recovery and Climate Experiment) graceful graph gradient Graham, Ronald (1935 ---RRB- Graham, Thomas (1805 — 1869) Graham's law of diffusion Graham's number GRAIL (Gravity Recovery and Interior Laboratory) grain (cereal) grain (unit) gram gram - atom Gramme, Zénobe Théophile (1826 — 1901) gramophone Gram's stain Gran Telescopio Canarias (GTC) Granat Grand Tour grand unified theory (GUT) Grandfather Paradox Granit, Ragnar Arthur (1900 — 1991) granite granulation granule granulocyte graph graph theory graphene graphite GRAPHS AND GRAPH THEORY graptolite grass grassland gravel graveyard orbit gravimeter gravimetric analysis Gravitational Biology Facility gravitational collapse gravitational constant (G) gravitational instability gravitational lens gravitational life gravitational lock gravitational microlensing GRAVITATIONAL PHYSICS gravitational slingshot effect gravitational waves graviton gravity gravity gradient gravity gradient stabilization Gravity Probe A Gravity Probe B gravity - assist gray (Gy) gray goo gray matter grazing - incidence telescope Great Annihilator Great Attractor great circle Great Comets Great Hercules Cluster (M13, NGC 6205) Great Monad Great Observatories Great Red Spot Great Rift (in Milky Way) Great Rift Valley Great Square of Pegasus Great Wall greater omentum greatest elongation Green, George (1793 — 1841) Green, Nathaniel E. 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The arrangement of genes on the chromosome is not a map of the plant's regulatory circuits.

Genome mapping is used to identify and record the location of genes and the distances between genes on a chromosome.

Botstein and Davis» landmark conceptual breakthrough, published in 1980, gave researchers the tools to trace and map out the genetic inheritance of disease in humans, while Hogness» work provided the means of identifying the precise physical location of genes of interest on chromosomes.

Gene - level expression values were represented by fragments per kilobase exon per million reads mapped (FPKM) and a consensus FPKM was determined for each gene based on its representation across biological replicaGene - level expression values were represented by fragments per kilobase exon per million reads mapped (FPKM) and a consensus FPKM was determined for each gene based on its representation across biological replicagene based on its representation across biological replicates.