Sentences with phrase «on gene variations»

The researchers then zeroed in on the gene variations that occurred more often in the people with bipolar disorder and examined them individually.

All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche.

Not exact matches

In this paper, I tried to interpret evolution as a continually shifting balance, spatially and temporally, among what I called the pressures of mutation, selection, and migration on gene frequencies, in conjunction with the effects of random drift composed of random variations in these pressures and of local accidents of sampling.

In the current study, Whitney, along with colleagues John Hinson, WSU professor of psychology, and Hans Van Dongen, director of the WSU Sleep and Performance Research Center at WSU Spokane, compared how people with different variations of the DRD2 gene performed on tasks designed to test both their ability to anticipate events and their cognitive flexibility in response to changing circumstances.

Sleep - deprived people with two other variations of the gene tend to perform much more poorly on the same kinds of tasks, the researchers found.

Based on the core principles of behavioral genetics, if genetics explain variations in distrust and trust behaviors, then identical twins should behave more similarly to each other than fraternal twins, since the genes of identical twins are shared, while the genes of fraternal twins are only imperfectly correlated, Reimann said.

«Identifying which of these candidate genes actually causes variation in responses to cold snaps will give us the potential to understand whether evolution to climate change can occur in both wild and domesticated animals, allowing us to better predict which species or breeds will be «winners» and «losers» and to better mitigate the effects of anthropogenic climate change on a wide range of organisms from beneficial pollinators to invasive pests,» said Theodore Morgan an associate professor of evolutionary genetics in the Division of Biology at Kansas State University and senior author of the study.

The researchers identified at least five variations whose correlation with a certain disease depended on whether the gene is maternal or paternal.

More recently, it has become clear that slight variations in the regulatory sequences that determine when a gene is switched on,...

Moffitt researchers focused their attention on inherited genetic variations in genes called interleukins.

Brin writes on his blog that the genome scan of his saliva from 23andMe told him he has a mutation on the LRRK2 gene, a variation called G2019S, which ups the risk for Parkinson's in some families.

They compared each individual's lifespan to that of their relatives and their degree of separation and found that genes explained about 16 percent of the longevity variation seen in their data — on the low end of previous estimates which have ranged from about 15 percent to 30 percent.

The results, which focus on two choices near the start of embryo formation, show that, when cells are making decisions about what to become, there is greater variation in the activity of the genes in different cells — the same genes may be turned on in some cells and off in others.

Strong variation, however, is found on the top of the cascade, meaning different master genes exist and it also varies on which amphibian chromosome the master gene is situated.

«A study covering a large number of subjects, like the one in 2015, makes it possible to identify the relevant genes across the entire population; but their variations have only a limited impact on individuals.

Researchers looked for regions of each plant's genome that showed unusual patterns of variation consistent with past selective breeding acting on the VRN - D4 gene.

The tests and scans revealed that variation in the genetic code of genes known as ARVCF and FADS2 influenced the risk of brain injury on MRI in the babies.

The map is a key tool that geneticists rely on to find disease genes and identify the functional genetic variations at the core of human diversity.

Focusing on specific genes or regions is an especially good strategy for taxonomy projects, where variation in a few genes is often sufficient to place an organism on a phylogenetic tree.

The international team, led by Professor Jacob George and Doctor Mohammed Eslam at the Westmead Institute, had previously identified that the common genetic variations associated with liver fibrosis were located on chromosome 19 between the IFNL3 and IFNL4 genes.

Variations on the FAAH gene can alter how people perceive threats and rewards.

Biologist Steven Rose is right that the relative contributions of genes and environment to IQ variation depend on the population...

As a result, researchers have tended to focus on point variations, such as the mutation or deletion of a single DNA letter within a gene.

The research team demonstrated that ranking genes based on inter-tumor variation in gene expression outperforms traditional analytical approaches.

In addition to reporting on genetic variation in a gene that is active in fast muscle fibers at The Biology of Genomes meeting, MacArthur wrote several on the spot blog posts covering advances discussed by the participants.

And the gene variation has effects on hundreds of other genes as well, causing a cascade effect that the researchers have not yet fully charted.

And some women with the variation are spared as well, depending on whether they received the gene from their mothers or their fathers.

In this case, the gene variation has dramatic effects on the fat cells on women's abdomens and hips, causing the cells to become larger but fewer.

To find out how DISC1 acts on synapses, the researchers also compared the activity levels of genes in the healthy neurons to those with the variation.

Across all four cancer types, the new method of selecting candidate genes based on inter-tumor variation in gene expression outperformed the other methods, including the standard method of comparing mean expression in adjacent normal and tumor tissues.

Indeed, the team identified high variation in adjacent «normal» tissue samples, which are typically used as control samples for comparison in analyses based on mean gene expression.

Spark Therapeutics hopes to win U.S. approval in January 2018 for a gene therapy to cure a rare inherited form of blindness, while Novartis could get a U.S. go - ahead as early as next month for its gene - modified cell therapy against leukaemia - a variation on standard gene therapy.

«Natural resistance to malaria linked to variation in human red blood cell receptors: First study to identify protective effect of glycophorin gene rearrangements on malaria.»

Although gene variations are primarily inherited at conception, the findings show that environmental impacts can also introduce them later on.

«This approach of focusing on protein - changing variation may help us zero in on new genes faster.»

In contrast, cis - eQTLs — which account for the majority of genetic variation that affects gene expression — regulate genes located nearby on the same chromosome.

So geneticists have been focusing on the dog as a possible model for gene searches because this lack of sequence variation may help them circumvent a frequent problem with studies in humans.

«One of Hlusko's goals is to detect and identify a few of these genes with major effects on variation in tooth size and shape in general.

«The consequences of genetic variation on gene expression are gradually becoming clearer.»

GenProfile focuses on the systematic analysis of DNA sequence variation in biomedically relevant genes in order to identify those variants, or combinations of variants (gene profiles), that determine an individual's genetic risk for disease, predict individually different drug response, and ultimately pave the way to a personalized medicine.

Adding further support to the intersection of CNTNAP2 and language, Fisher's collaborator Daniel Geschwind of the University of California, Los Angeles, reported in January on an association between a variation in the gene and a delay in the use of first words in children with autism.

In addition to identifying a gene that raises risk for colorectal cancer from eating red or processed meat, the study — the first to identify the interactions of genes and diet on a genome - wide scale — also reveals another specific genetic variation that appears to modify whether eating more vegetables, fruits and fiber actually lowers your colorectal cancer risk.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

For this study, the team, which also included Bernard Crespi, an evolutionary biology professor at Simon Fraser University in British Columbia, and East Carolina University evolution professor Kyle Summers, focused on 76 gene variations most strongly related to schizophrenia.

This study further investigated the impact of nicotine use / smoking status and variation in the mu opioid receptor gene (OPRM1), specifically, an A118G single nucleotide polymorphism (SNP, or DNA sequence variation), on the effects of naltrexone on a range of drinking outcomes.

On January 9, a team, led by researchers at Massachusetts General Hospital (MGH) and Children's Hospital Boston, announced that it had found copy number variations — deletions of duplications of segments of genetic code that alter the number of copies of a gene a person carries — in 12 of 1,400 autism sufferers it was studying.

Additional examination of the two genes in anoxeria - prone families gave the researchers a handle on which DNA sequence variations conferred the most risk.

Some research teams over the past five years have used microarray or gene - chip technology to compare genomes and quickly scan them for variations of copy numbers on each chromosome.

According to Hahn, the data argue that the time is ripe to pay more attention to the broader landscape of functional aspects of cancer, in addition to focusing on protein - coding gene mutations and variations.

A new sequencing technology based on longer sequence reads allows missing genes and missing forms of genetic variation to be discovered for the first time.